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Ovarian Yolk Sac Tumors; Does Age Matter?
Conclusions Ovarian yolk sac tumors have an excellent outcome across all age-groups. Age has no apparent impact on the probability of event or death, allowing pediatric and gynecologic oncologists to enroll patients onto joint pediatric and adult trials.
Source: International Journal of Gynecological Cancer - December 22, 2017 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Primary extragonadal yolk sac tumor originating from adrenal gland.
We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. PMID: 31860425 [PubMed - in process]
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

High-grade serous carcinoma of fallopian tube with yolk sac tumor differentiation in a postmenopausal patient.
Abstract Yolk sac tumors (YSTs) are the second most common germ cell malignancy of the ovaries, generally presenting in children and young women. However, they rarely occur in the fallopian tubes of postmenopausal patients. The current rare case is composed of yolk sac tumor differentiation within high-grade serous carcinoma (HGSC) arising in the fallopian tube of a 68-year-old woman. Serum α-fetoprotein was much higher than normal level. This case exhibited some areas of glandular architecture with positivity for SALL4, AFP, and Glypican-3 and negative staining for PAX8, supporting a germ cell tumor differentiat...
Source: International Journal of Clinical and Experimental Pathology - July 16, 2020 Category: Pathology Authors: Xing F, Jiang L, Wang T, Li W, Yang P, Qu G, Bao L Tags: Int J Clin Exp Pathol Source Type: research

Cancers, Vol. 13, Pages 220: Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)
Marie Morfouace Isabelle Ray-Coquard Most patients with malignant ovarian germ cell tumors (MOGTCs) have a very good prognosis and chemotherapy provides curative treatment; however, patients with yolk sac tumors (OYSTs) have a significantly worse prognosis. OYSTs are rare tumors and promising results are expected with the use of specific therapeutic strategies after the failure of platinum-based first-line and salvage regimens. We initiated a project in collaboration with EORTC SPECTA, to explore the molecular characteristics of OYSTs. The pilot project used retrospective samples from ten OYST relapsed and disease-...
Source: Cancers - January 9, 2021 Category: Cancer & Oncology Authors: Khalil Hodroj Aleksandra Stevovic Valery Attignon Domenico Ferraioli Pierre Meeus Sabrina Croce Nicolas Chopin Lea Rossi Anne Floquet Christine Rousset-Jablonski Olivier Tredan Fr édéric Guyon Isabelle Treilleux Corinne Rannou Marie Morfouace Isabelle R Tags: Article Source Type: research

Somatically Derived Yolk Sac Tumor of the Ovary in a Young Woman
Ovarian carcinoma with a somatically derived yolk sac tumor component is a phenomenon known to mostly occur in postmenopausal women. Herein, we report an ovarian endometriosis-associated somatic yolk sac tumor arising in the background of a low-grade endometrioid adenocarcinoma in a young woman. A 27-yr-old woman presented with abdominal pain, subsequently recognized to be caused by a right ovarian mass undergoing torsion. Following operative management, microscopic examination of the salpingo-oophorectomy specimen showed endometriosis and a predominantly cystic ovarian neoplasm with 2 distinct phenotypic areas: (1) a yolk...
Source: International Journal of Gynecological Pathology - April 16, 2021 Category: Pathology Tags: PATHOLOGY OF THE UPPER TRACT: Case Reports Source Type: research

Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options
AbstractSMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with y...
Source: Head and Neck Pathology - August 21, 2021 Category: Pathology Source Type: research

SMARCB1 (INI1)-Deficient Sinonasal Carcinoma with Yolk Sac differentiation Showing Co-loss of SMARCA4 Immunostaining – A Case Report and Literature Review
We report the first case of SMARCB1-deficient sinonasal carcinoma that demonstrated co-loss of SMARCA4 immunostain, and reduced SMARCA2 and ARID1A staining, with the entire tumor showing histological and immunohistochemical evidence of yolk sac differentiation. The clinical, histological, immunohistochemical and molecular features were discussed and compared against SMARCB1-deficient sinonasal carcinomas with yolk sac differentiation and SMARCA4-deficeint sinonasal carcinomas reported in the literature. With a highly aggressive clinical course leading to mortality two months after presentation, the behavior of this tumor a...
Source: Head and Neck Pathology - March 7, 2022 Category: Pathology Source Type: research

Cancer Stem Cell Markers — CD133 and CD44 — in Paediatric Solid Tumours: A Study of Immunophenotypic Expression and Correlation with Clinicopathological Parameters
This study was a cross-sectional observational study conducted in the department of pathology at a tertiary care centre. All the histologically diagnosed paediatric solid tumours for a period of one year and four months were retrieved from the archives. The cases were reviewed and included in the study after obtaining informed con sent. Immunohistochemistry using the monoclonal antibodies for CD133 and CD44 was performed in the representative tissue sections of all the cases. Immuno-scores were assessed, and the results were compared using Pearson’s chi-square test. The present study included 50 cases of paediatric solid...
Source: Indian Journal of Surgical Oncology - August 28, 2022 Category: Cancer & Oncology Source Type: research

Ovarian yolk sac tumor in a  premenarchal girl
We describe the case of an ovarian yolk sac tumor in a 12-year-old premenarchal girl suffering from Hashimoto’s thyroiditis and chronic spontaneous urticaria, which presented as a rapidly growing solid cystic formation in the hypogastrium with an extreme increase in alpha fetoprotein (52,778 mg/ml). After ultrasound and MRI imaging, fertility-sparing staging surgery was performed, and the diagnosis of an ovarian yolk sac tumor with positive malignant cells in ascites was confirmed. The specificity of this case is the tumor classification into stag e IC3 according to the FIGO and stage III according to the Childrenâ€...
Source: Wiener Medizinische Wochenschrift - January 13, 2023 Category: General Medicine Source Type: research

Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors
CONCLUSION: Generally a high frequency of CTLA4 expression was found, PD-1/PD-L1 expression, the immune-inflamed phenotype, and TLSs were low frequency in YSTs, however, YSTs in testes showed a higher density of TILs and higher expression of immune checkpoint molecules.PMID:37453913 | DOI:10.1016/j.humimm.2023.07.003
Source: Human Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Danya Zhang Hanjie Xu Can Zhao Lingzhi Qin Rui Wei Ling Xi Fei Li Source Type: research

Sacrococcygeal yolk sac tumor developing after teratoma: A clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors
Conclusions: The characteristics of SGCT in Japanese children were similar with those reported in Europe or the United States. YST developed after SCT resection not only in patients with previously reported risk factors. We recommend that patients undergo serum AFP monitoring every 3months for≥3years after SCT resection.
Source: Journal of Pediatric Surgery - April 1, 2013 Category: Surgery Authors: Mariko Yoshida, Kentaro Matsuoka, Atsuko Nakazawa, Makiko Yoshida, Takeshi Inoue, Hiroshi Kishimoto, Masahiro Nakayama, Emi Takaba, Minoru Hamazaki, Shigeaki Yokoyama, Hiroshi Horie, Mio Tanaka, Kiyoshi Gomi, Youkatsu Ohama, Hisato Kigasawa, Yoshihiro Kit Tags: Original Articles Source Type: research