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Total 5323794 results found since Jan 2013.

Renal Yolk Sac Tumor Clinically Misdiagnosed as Nephroblastoma: A Case Report
Conclusion: Imaging examination of renal yolk sac tumor can easily be misdiagnosed as Wilms tumor. SIOP treatment plan for Wilms tumor requires preoperative chemotherapy, which is different from the treatment regimen for yolk sac tumor. Preoperative alpha-fetoprotein could have been helpful in avoiding this clinical misdiagnosis.PMID:36645844 | DOI:10.1080/15513815.2023.2166800
Source: Fetal and Pediatric Pathology - January 16, 2023 Category: Pathology Authors: Meng Zhu Chengmao Xia Jie Yang Zhe Liu Xiaowen Zhao Yaling Li Bin Liu Yanli Yang Yali She Source Type: research

Metastatic yolk sac tumor masquerading as multifocal hepatocellular carcinoma in a young adult: A case report
We present a case of a young adolescent who presented with bleeding per rectum abdominal pain and multiple liver lesions.
Source: Clinical Case Reports - February 3, 2023 Category: General Medicine Authors: Kamran Mushtaq, Muhammad Umair Khan, Deema Al  Soub, Sheija Mary Koshy, Maher Petkar, Khalid Mohsin Al Ejji Tags: CASE REPORT Source Type: research

Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Int J Cancer. 2023 Aug 26. doi: 10.1002/ijc.34697. Online ahead of print.ABSTRACTMalignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bloodstream, presumed within extracellular-vesicles (EVs) and represent promising biomarkers. Here, we comprehensively examined the role of EVs, and their miRNA cargo, on (fibroblast/endothelial/macrophage) cells representative of the testicular GCT (...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Luz Alonso-Crisostomo Jennifer Trendell Marta Ferraresso Shivani Bailey Dawn Ward Zachary G L Scurlock Stephanie C Wenlock Carlos A P Bastos Ravin Jugdaohsingh Nuno J Faria Anton J Enright Cinzia G Scarpini Nicholas Coleman Matthew J Murray Source Type: research

SALL4 and SF-1 Are Sensitive and Specific Markers for Distinguishing Granulosa Cell Tumors From Yolk Sac Tumors
In this study, the authors performed immunohistochemical stains for SALL4 and steroidogenic factor-1 (SF-1) on 27 cases of yolk sac tumors and 24 granulosa cell tumors. Nuclear stains for both antibodies were considered as positive and the intensity of staining was graded as negative, weak, moderate, and strong. All the yolk sac tumors were positive for SALL4 (100%) with moderate to strong grade staining and negative for SF-1 (100%). In contrast, all the granulosa cell tumors were positive for SF-1 (85% moderate to strong grade staining and 15% weak staining) and negative for SALL4 (100%). The difference was significant (P...
Source: International Journal of Surgical Pathology - March 20, 2013 Category: Pathology Authors: Bai, S., Wei, S., Ziober, A., Yao, Y., Bing, Z. Tags: Original Articles Source Type: research

Pediatric germ cell tumours.
Abstract Germ cell tumours include a group of highly heterogeneous tumours regarding to their clinical and histological appearance. Altogether, they represent 3% of cancers diagnosed in children and adolescent younger than 15 years. A bimodal age distribution is observed with a small peak during infancy and a larger peak after puberty. Non-seminomateous germ cell tumours are largely predominant as compared to seminomateous tumours, rarely seen before puberty. During infancy, sacrococcygeal locations predominate with either teratomas in neonates or yolk sac tumours in infants above three months. In adolescents, mix...
Source: Bulletin du Cancer - April 1, 2013 Category: Cancer & Oncology Authors: Faure-Conter C, Rocourt N, Sudour-Bonnange H, Vérité C, Martelli H, Patte C, Frappaz D, Orbach D Tags: Bull Cancer Source Type: research

A diagnostic immunohistochemical panel for yolk sac (primitive endodermal) tumours based on an immunohistochemical comparison with the human yolk sac
ConclusionsCPs reproduce the immunophenotype of HYS and early endoderm with variable expression of both AFP and markers of early gut or hepatic differentiation. SGPs with intestinal differentiation often have incomplete immunophenotypes. A differential diagnosis panel including both markers of pluripotentiality (SALL4 and LIN28) and endoderm (AFP, GPC3 and villin) is proposed. It identifies overlapping multidifferentiation of primitive and somatic immunophenotypes, supporting the recently proposed term of primitive endodermal tumours.This article is protected by copyright. All rights reserved.
Source: Histopathology - January 20, 2014 Category: Pathology Authors: Francisco F. Nogales, Enoe Quiñonez, Laura López‐Marín, Isabel Dulcey, Ovidiu Preda Tags: Original Article Source Type: research

Detection of a metastatic lesion and tiny yolk sac tumors in two teenage patients by FDG-PET: report of two cases
Abstract We herein report the efficacy of FDG-PET for detecting yolk sac tumors in two teenage patients. One patient had a rare bone metastasis and the other had tiny recurrent lesions at the mediastinum. Both lesions were difficult to detect by conventional diagnostic modalities. In contrast, FDG-PET was very effective for detecting these lesions. Furthermore, the SUVmax of the lesion reflected the tumor activity, which was also suggested by the fluctuating values of serum alpha-fetoprotein (AFP), an established marker of yolk sac tumors. FDG-PET may be a useful procedure to detect tiny and metastatic, pediatric yolk sac tumors.
Source: Surgery Today - September 25, 2014 Category: Surgery Source Type: research

Abstract 77: bcl-xL protein overexpression enhances tumor progression of human melanoma cells in zebrafish xenograft model: Involvement of CXCL8 chemokine
The anti-apoptotic protein bcl-xL, whose expression is associated with melanoma progression, enhances metastatic potential in different tumor hystotypes and promotes tumor angiogenesis through enhancing pro-inflammatory chemokine interleukin 8 (CXCL8) expression. Using the derivative clones of human melanoma M14 cell line stably overexpressing bcl-xL protein, we evaluated the impact of bcl-xL/CXCL8 axis in promoting melanoma angiogenesis and aggressiveness in vivo using zebrafish as experimental model. Implantation of M14 trasfectants overexpressing bcl-xL protein into the yolk sac of 2 days post-fertilization (dpf) zebraf...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gabellini, C., Gomez, E., Oliveira, S. d., Bufalo, D. D., Mulero, V. Tags: Tumor Biology Source Type: research

Radiological-pathological correlation of yolk sac tumor in 20 patients.
CONCLUSION: YST usually appears as a large solid-cystic mass with intratumoral hemorrhage, capsular tear, marked heterogeneous enhancement, and enlarged intratumoral vessels on CT images. Intratumoral calcification and fatty tissue, although rare, may indicate a mixed YST containing teratoma component. PMID: 25492969 [PubMed - as supplied by publisher]
Source: Acta Radiologica - December 9, 2014 Category: Radiology Authors: Li Y, Zheng Y, Lin J, Xu G, Cai A, Chen R, Wu M Tags: Acta Radiol Source Type: research

Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome.
Abstract Tumour lysis syndrome (TLS) and choriocarcinoma syndrome (CS) are severe complications of chemotherapy for testicular cancer. They are rare, but can be life-threatening. A 37-year-old man complaining of persisting cough was referred to our hospital. A computed tomography (CT) scan revealed huge tumours that occupied the peritoneal cavity, with multiple lung, liver, and para-aortic metastases. Although there was no abnormal finding in the testes, serum testicular tumor markers showed marked elevation. A CT-guided biopsy for the peritoneal tumours revealed extragonadal germ cell tumour (GCT), including yolk...
Source: Canadian Urological Association Journal - January 1, 2015 Category: Urology & Nephrology Authors: Kobatake K, Kato M, Mita K Tags: Can Urol Assoc J Source Type: research

Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.
Authors: Akutsu N, Adachi Y, Isosaka M, Mita H, Takagi H, Sasaki S, Yamamoto H, Arimura Y, Ishii Y, Masumori N, Endo T, Shinomura Y Abstract Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effe...
Source: Internal Medicine - June 16, 2015 Category: Internal Medicine Tags: Intern Med Source Type: research

RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors
Conclusions LIN28 is a sensitive marker for pediatric YSTs and it can be used to distinguish them from mature teratomas. LIN28 is likely to become a new and valuable biomarker for diagnosing of pediatric YST.
Source: Pediatric Surgery International - June 28, 2016 Category: Surgery Source Type: research