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Total 15067 results found since Jan 2013.
Editorial: Emerging swine viral pathogens: virus evolution, epidemiology, molecular pathogenesis and disease control strategies
Source: Frontiers in Microbiology - August 25, 2023 Category: Microbiology Source Type: research
Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine
This study sheds lights on the intricate RNA interplay during PRRSV infection and provides a solid foundation for future therapeutic strategizing.
Source: Frontiers in Immunology - August 24, 2023 Category: Allergy & Immunology Source Type: research
An Animal Model of Functional Tricuspid Regurgitation by Leaflet Tethering Using Image-Guided Chordal Encircling Snares
AbstractSeveral interventional therapies are in development to treat functional tricuspid regurgitation. Most have failed to achieve adequate efficacy, as animal models of this lesion are lacking. We developed a new image-guided technique in swine, by tethering the tricuspid valve chordae using echo-guided chordal encircling snares. Five swine underwent baseline echocardiographic assessment of tricuspid valve function, followed by echo-guided placement of snares that encircle the chordae inserting into the anterior and posterior tricuspid valve leaflets. Tethering these snares and stabilizing them on the right ventricle ca...
Source: Journal of Cardiovascular Translational Research - August 24, 2023 Category: Cardiology Source Type: research
The Angle of His as a Measurable Element of the Anti-reflux Mechanism
ConclusionsIn this study, we developed an experimental model to enable careful evaluation of the elements of the anti-reflux mechanism, of which, the angle of His has a measurable element. We demonstrated that as the angle of His becomes wider the esophago-gastric orifice area becomes larger. Additionally, a wider angle of His and a larger esophago-gastric orifice area were correlated independently with more reflux. This suggests that the fundoplication creates an acute angle of His which is correlated with a smaller area of the esophago-gastric orifice and eventually with a lower incidence of reflux.
Source: Journal of Gastrointestinal Surgery - August 24, 2023 Category: Surgery Source Type: research
An Animal Model of Functional Tricuspid Regurgitation by Leaflet Tethering Using Image-Guided Chordal Encircling Snares
AbstractSeveral interventional therapies are in development to treat functional tricuspid regurgitation. Most have failed to achieve adequate efficacy, as animal models of this lesion are lacking. We developed a new image-guided technique in swine, by tethering the tricuspid valve chordae using echo-guided chordal encircling snares. Five swine underwent baseline echocardiographic assessment of tricuspid valve function, followed by echo-guided placement of snares that encircle the chordae inserting into the anterior and posterior tricuspid valve leaflets. Tethering these snares and stabilizing them on the right ventricle ca...
Source: Journal of Cardiovascular Translational Research - August 24, 2023 Category: Cardiology Source Type: research
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
"Catch-up" therapy: combining antidotal treatment with dermal application of AHA following percutaneous VX poisoning in the domestic swine
Arch Toxicol. 2023 Aug 23. doi: 10.1007/s00204-023-03574-5. Online ahead of print.ABSTRACTLow-volatility organophosphorus chemical warfare agents (OP CWAs) are cholinesterase inhibitors which easily absorb into the skin, leading to the formation of a dermal depot from which they slowly enter the bloodstream. This leads to sustained cholinergic hyperstimulation, which if untreated may lead to death. However, current available countermeasures are not adequate to neutralize the agent residing in the dermal depot. Accordingly, we evaluated the efficacy of the potassium salt of acetohydroxamic acid (880 mg/ml in DMSO/H2O 1:4, A...
Source: Archives of Toxicology - August 23, 2023 Category: Toxicology Authors: Eugenia Bloch-Shilderman Uri Nili Victoria Nahum Boris Smolkin Nissan Ashkenazi Source Type: research
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
Human Infections With Swine Influenza Viruses Identified in US
Two people who recently attended different agricultural fairs in Michigan have contracted influenza viruses from pigs, the Centers for Disease Control and Prevention (CDC) reported on August 4. One patient was presumed to be positive for influenza A(H3) variant virus based on local epidemiological findings. Diagnostic testing confirmed the second person ’s infection with influenza A(H1N2) variant virus.
Source: JAMA - Journal of the American Medical Association - August 23, 2023 Category: General Medicine Source Type: research
Inactivation of African swine fever virus inoculated in liquid plasma by spray drying and storage for 14 days at 4 °C or 20°C
The objectives were to test if the spray-drying (SD) con ditions along with post-drying storage of product for 14 days can inactivate ASFV inoculated in liquid plasma. Fresh liquid porcine plasma was inoculated with ASFV (BA71V) to a final concentration of 105.18 ±0.08 TCID50/mL of liquid plasma. Triplicate 2-L samples of spiked plasma were SD in a lab drier set at an outlet temperature of 80 °C or 71°C. The final dried samples were stored at 4°C or 20°C for 14 d. Liquid and SD samples were analyzed for ASFV infectivity in two mirror 24-well plaques containing VERO cells monolayers. Wells were inoculated with differen...
Source: PLoS One - August 22, 2023 Category: Biomedical Science Authors: Elena Bl ázquez Source Type: research
Role of OGDH in Atophagy-IRF3-IFN- β pathway during classical swine fever virus infection
In this study, we found that CSFV significantly reduces OGDH protein levels and promotes α-KG secretion through OGDH in PK-15 cells. Furthermore, we observed CSFV C protein interacts with OGDH and revealed that CSFV utilizes NDP52/NBR1 to target OGDH protein degradation in the autophagy-lysosome pathway. We also unveiled that OGDH overexpression inhibits CSFV proliferation, whereas OGDH knockdown increases CSFV proliferation. Further investigation into the mechanisms of OGDH on CSFV replication revealed that OGDH regulates the AMPK-mTOR-autophagy pathway. Additionally, using the autophagy agonist/inhibitor, rapamycin/3-MA...
Source: International Journal of Biological Macromolecules - August 21, 2023 Category: Biochemistry Authors: Sen Zeng Wenhui Zhu Zipeng Luo Keke Wu Zhimin Lu Xiaowen Li Weijun Wang Wenshuo Hu Yuwei Qin Wenxian Chen Lin Yi Shuangqi Fan Jinding Chen Source Type: research
The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo
This study provides a scientific basis for the research and development of antimicrobial peptides as new antimicrobial agents.
Source: Veterinary Research - August 21, 2023 Category: Veterinary Research Source Type: research
Nanoengineered phosphorus doped graphitic carbon nitride based ultrasensitive biosensing platform for Swine flu detection
Colloids Surf B Biointerfaces. 2023 Aug 7;230:113504. doi: 10.1016/j.colsurfb.2023.113504. Online ahead of print.ABSTRACTIn the present study, we developed an amino-polyindole modified phosphorus doped graphitic carbon nitride nanomaterial (APIN/P-g-C3N4) based immunosensing biochip for Serum amyloid A (SAA) biomarker towards early diagnosis of Swine flu. The P-g-C3N4 was synthesis via polycondensation and functionalized with APIN. Further, the biochip was fabricated by modifying the working area of SPE with APIN/P-g-C3N4 using drop cast method, APIN introduced the larger loading of -NH2 group moieties onto P-g-C3N4 matrix...
Source: Colloids and Surfaces - August 19, 2023 Category: Biotechnology Authors: Vishakha Nirbhaya Ramesh Chandra Suveen Kumar Source Type: research
