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Total 15067 results found since Jan 2013.

Molecular breeding of livestock for disease resistance
Virology. 2023 Aug 4;587:109862. doi: 10.1016/j.virol.2023.109862. Online ahead of print.ABSTRACTAnimal infectious diseases pose a significant threat to the global agriculture and biomedicine industries, leading to significant economic losses and public health risks. The emergence and spread of viral infections such as African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and avian influenza virus (AIV) have highlighted the need for innovative approaches to develop resilient and disease-resistant animal populations. Gene editing technologies, ...
Source: Virology - August 10, 2023 Category: Virology Authors: Fei Gao Pan Li Ye Yin Xuguang Du Gengsheng Cao Sen Wu Yaofeng Zhao Source Type: research

SY18 ΔL60L: a new recombinant live attenuated African swine fever virus with protection against homologous challenge
DiscussionThese results suggest that L60L could serve as a virulence- and replication-related gene. Moreover, the SY18ΔL60L strain represents a new recombinant live-attenuated ASFV that can be employed in the development of additional candidate vaccine strains and in the elucidation of the mechanisms associated with ASF infection.
Source: Frontiers in Microbiology - August 9, 2023 Category: Microbiology Source Type: research

First Detection and Characterization of Hepatitis E Virus in Sewage Samples in Cameroon
This study aimed to assess the presence of HEV in the environment in Cameroon through molecular analysis of sewage samples. Retrospectively, a total of 157 sewage samples collected between January 2018 and December 2019 were randomly selected and analyzed by molecular techniques to detect and characterize the HEV followed by sequencing and phylogenetic analysis. Three samples (1.9%) collected from North, Far North, and Adamawa regions were positive by real-time reverse transcription polymerization chain reaction. Among these, 2 samples were positive for HEV ribonucleic acid by nested reverse transcription polymerization ch...
Source: Food and Environmental Virology - August 9, 2023 Category: Virology Source Type: research

Transition of  Resuscitative Endovascular Balloon Occlusion of the Aorta from Zone 3 to Zone 1 to Treat Hemodynamic Collapse during Continued Hemorrhage
CONCLUSIONS: In this swine model of NCTH, hemodynamics and survival were improved when the REBOA balloon was transitioned from zone 3 to zone 1 during an impending cardiovascular collapse. Furthermore, these improved outcome data support the pursuit of additional research into mitigating ischemia-reperfusion insult to the abdominal viscera while still providing excellent resuscitative support, such as intermittent or partial REBOA.PMID:37552642 | DOI:10.1093/milmed/usad313
Source: Military Medicine - August 8, 2023 Category: International Medicine & Public Health Authors: Jason M Rall Kimberly J Baker Melody L Sandoval Ashley N Flinn Marlin W Causey Source Type: research

Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
P. M. van Diemen et al.
Source: Emerging Infectious Diseases Journal - August 8, 2023 Category: Infectious Diseases Source Type: research

Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil
DiscussionThe virus underwent continuous antigenic drift, and a balance was established between swine-to-swine transmission and extinction, with minimal sustained onward transmission from humans to swine. These results emphasize the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
Source: Frontiers in Microbiology - August 8, 2023 Category: Microbiology Source Type: research

SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses
Biochim Biophys Acta Mol Basis Dis. 2023 Aug 5:166836. doi: 10.1016/j.bbadis.2023.166836. Online ahead of print.ABSTRACTSince 2003, we have seen the emergence of novel viruses, such as SARS-CoV-1, MERS, ZIKA, swine flu virus H1N1, Marburg, Monkeypox, Ebola, and SARS-CoV-2, but none of them gained pandemic proportions similar to SARS-CoV-2. This could be attributed to unique viral traits, allowing its rapid global dissemination following its emergence in October 2019 in Wuhan, China, which appears to be primarily driven by the emergence of highly transmissible and virulent variants that also associate, in some cases, with s...
Source: Biochimica et Biophysica Acta - August 7, 2023 Category: Biochemistry Authors: Nitin K Saksena Srinivas Bonam Reddy Monica Miranda-Saksena Thyago H S Cardoso Edson M A Silva Juliana C Fereira Wael M Rabeh Source Type: research

Doctor and Child Found Dead; Human Swine Flu Cases; Rescued Lab Beagles' New Homes
(MedPage Today) -- Note that some links may require registration or subscription. Mount Sinai Hospital oncologist Krystal Cascetta, MD, and her baby were found dead of gunshot wounds at their home on Saturday in an apparent murder-suicide, according...
Source: MedPage Today Public Health - August 7, 2023 Category: American Health Source Type: news

Two people in Michigan are infected with SWINE FLU after attending county fairs, CDC reveals
The patients - whose infections are not linked to one another - contracted different strains at separate fairs last month, where they were 'exposed' to infected pigs.
Source: the Mail online | Health - August 4, 2023 Category: Consumer Health News Source Type: news

Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia
This study reveals that MetS and ischemia diminishes ATP availability in the myocardium via altering t he glucose-G6P-pyruvate axis at the level of metabolites and gene expression of related enzymes. The observed severe glycogen depletion in MetS coincides with disbalance in expression of GYS1 and both PYGM and PYGL. This altered energy substrate metabolism is a potential target of pharmacological ag ents for improving juvenile myocardial function in MetS and ischemia.
Source: Physiological Reports - August 4, 2023 Category: Physiology Authors: Mark Broadwin, Dwight D. Harris, Sharif A. Sabe, Elif Sengun, Amber J. Sylvestre, Boian S. Alexandrov, Frank W. Selke, Anny Usheva Tags: ORIGINAL ARTICLE Source Type: research

Morphometric characterization and temporal temperature measurements during hepatic microwave ablation in swine
ConclusionMWA results are challenging to predict and are more variable than manufacturer-provided and bench predictions due to vascular stasis, heat-induced tissue changes, and probe operating conditions. Accurate prediction of MWA zones and temperaturein vivo requires comprehensive thermal validation sets.
Source: PLoS One - August 4, 2023 Category: Biomedical Science Authors: Nicole A. Varble Source Type: research

Establishment of a Mycoplasma hyorhinis challenge model in 5-week-old piglets
DiscussionOur results indicate that both challenge routes are suitable for modeling the disease. However, due to the evoked more severe pathological lesions and the application being similar to the hypothesized natural route of infection in Group IV-IV, the two-dose intravenous challenge is recommended by the authors to induce serositis and arthritis associated with M. hyorhinis infection.
Source: Frontiers in Microbiology - August 4, 2023 Category: Microbiology Source Type: research

The effects of carbon nitrogen ratio and salinity on the treatment of swine digestion effluent simultaneously producing bioenergy by microalgae biofilm
Chemosphere. 2023 Aug 1:139694. doi: 10.1016/j.chemosphere.2023.139694. Online ahead of print.ABSTRACTIn order to remove high concentrations of ammonia nitrogen (NH4+-N) and refractory sulfamethazine (SM2) from swine digestion effluent, different carbon/nitrogen (C/N) ratios and salinity were used to determine the effects of pollutants removal in the microalgae biofilm system. Microalgae biofilm treatment under optimal environmental conditions in synthetic swine digestion effluent were C/N ratio of 20 and salinity of 140 mM. In order to make the actual swine digestion effluent discharge up to the standard, three different ...
Source: Chemosphere - August 3, 2023 Category: Chemistry Authors: Yiwen Mou Na Liu Tianxiang Lu Cong Jia Chongqing Xu Mingming Song Source Type: research