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Detection of African Swine Fever Virus from Wild Boar, Singapore, 2023
Emerg Infect Dis. 2023 Sep 14;29(12). doi: 10.3201/eid2912.230966. Online ahead of print.ABSTRACTWe detected African swine fever virus (ASFV) from a wild boar in Singapore. In <72 hours, we confirmed and reported ASFV p72 genotype II, CD2v serogroup 8, and IGR-II variant by using a combination of real-time PCR and whole-genome sequencing. Continued biosurveillance will be needed to monitor ASFV in Singapore.PMID:37708842 | DOI:10.3201/eid2912.230966
Source: Emerging Infectious Diseases - September 14, 2023 Category: Infectious Diseases Authors: Eileen Y Koh Adrian K S Tan Darren Yeo Clara Lau Li Ying Tan Oi Wing Ng Jasmine Ong Stacy Chong Steffie Toh Jing Chen Wai Kwan Wong Brian Z Y Tan Christine He-Lee Zhan Pei Heng Ian Liang Charlene Judith Fernandez Siow Foong Chang Kenneth B H Er Source Type: research
Innate immune escape and adaptive immune evasion of African swine fever virus: A review
Virology. 2023 Sep 7;587:109878. doi: 10.1016/j.virol.2023.109878. Online ahead of print.ABSTRACTAfrican swine fever virus (ASFV) causes hemorrhagic fever in domestic and wild pigs. The continued spread of the virus in Africa, Europe and Asia threatens the global pig industry. The lack of an effective vaccine limits disease control. ASFV has evolved a variety of encoded immune escape proteins and can evade host adaptive immunity, inducing cellular inflammation, autophagy, or apoptosis in host cells. Frequent persistent infections hinder the development of a viral vaccine and impose technical barriers. Currently, knowledge ...
Source: Virology - September 14, 2023 Category: Virology Authors: Sai Niu Yilin Guo Xueying Wang Zixuan Wang Limeng Sun Hanchuan Dai Guiqing Peng Source Type: research
Detection of African Swine Fever Virus from Wild Boar, Singapore, 2023
Emerg Infect Dis. 2023 Sep 14;29(12). doi: 10.3201/eid2912.230966. Online ahead of print.ABSTRACTWe detected African swine fever virus (ASFV) from a wild boar in Singapore. In <72 hours, we confirmed and reported ASFV p72 genotype II, CD2v serogroup 8, and IGR-II variant by using a combination of real-time PCR and whole-genome sequencing. Continued biosurveillance will be needed to monitor ASFV in Singapore.PMID:37708842 | DOI:10.3201/eid2912.230966
Source: Emerging Infectious Diseases - September 14, 2023 Category: Infectious Diseases Authors: Eileen Y Koh Adrian K S Tan Darren Yeo Clara Lau Li Ying Tan Oi Wing Ng Jasmine Ong Stacy Chong Steffie Toh Jing Chen Wai Kwan Wong Brian Z Y Tan Christine He-Lee Zhan Pei Heng Ian Liang Charlene Judith Fernandez Siow Foong Chang Kenneth B H Er Source Type: research
Innate immune escape and adaptive immune evasion of African swine fever virus: A review
Virology. 2023 Sep 7;587:109878. doi: 10.1016/j.virol.2023.109878. Online ahead of print.ABSTRACTAfrican swine fever virus (ASFV) causes hemorrhagic fever in domestic and wild pigs. The continued spread of the virus in Africa, Europe and Asia threatens the global pig industry. The lack of an effective vaccine limits disease control. ASFV has evolved a variety of encoded immune escape proteins and can evade host adaptive immunity, inducing cellular inflammation, autophagy, or apoptosis in host cells. Frequent persistent infections hinder the development of a viral vaccine and impose technical barriers. Currently, knowledge ...
Source: Virology - September 14, 2023 Category: Virology Authors: Sai Niu Yilin Guo Xueying Wang Zixuan Wang Limeng Sun Hanchuan Dai Guiqing Peng Source Type: research
Analysis of polygenic selection in purebred and crossbred pig genomes using generation proxy selection mapping
CONCLUSIONS: This work confirms the efficacy and the negligible error rates of the GPSM method in detecting selected loci in commercial pig populations. Our results suggest shared selection objectives and genetic architectures across swine populations. The identified polygenic selection highlights loci that are important to swine production.PMID:37710159 | PMC:PMC10500877 | DOI:10.1186/s12711-023-00836-9
Source: Genet Sel Evol - September 14, 2023 Category: Genetics & Stem Cells Authors: Caleb J Grohmann Caleb M Shull Tamar E Crum Clint Schwab Timothy J Safranski Jared E Decker Source Type: research
Detection of African Swine Fever Virus from Wild Boar, Singapore, 2023
Emerg Infect Dis. 2023 Sep 14;29(12). doi: 10.3201/eid2912.230966. Online ahead of print.ABSTRACTWe detected African swine fever virus (ASFV) from a wild boar in Singapore. In <72 hours, we confirmed and reported ASFV p72 genotype II, CD2v serogroup 8, and IGR-II variant by using a combination of real-time PCR and whole-genome sequencing. Continued biosurveillance will be needed to monitor ASFV in Singapore.PMID:37708842 | DOI:10.3201/eid2912.230966
Source: Emerging Infectious Diseases - September 14, 2023 Category: Infectious Diseases Authors: Eileen Y Koh Adrian K S Tan Darren Yeo Clara Lau Li Ying Tan Oi Wing Ng Jasmine Ong Stacy Chong Steffie Toh Jing Chen Wai Kwan Wong Brian Z Y Tan Christine He-Lee Zhan Pei Heng Ian Liang Charlene Judith Fernandez Siow Foong Chang Kenneth B H Er Source Type: research
Innate immune escape and adaptive immune evasion of African swine fever virus: A review
Virology. 2023 Sep 7;587:109878. doi: 10.1016/j.virol.2023.109878. Online ahead of print.ABSTRACTAfrican swine fever virus (ASFV) causes hemorrhagic fever in domestic and wild pigs. The continued spread of the virus in Africa, Europe and Asia threatens the global pig industry. The lack of an effective vaccine limits disease control. ASFV has evolved a variety of encoded immune escape proteins and can evade host adaptive immunity, inducing cellular inflammation, autophagy, or apoptosis in host cells. Frequent persistent infections hinder the development of a viral vaccine and impose technical barriers. Currently, knowledge ...
Source: Virology - September 14, 2023 Category: Virology Authors: Sai Niu Yilin Guo Xueying Wang Zixuan Wang Limeng Sun Hanchuan Dai Guiqing Peng Source Type: research
Detection of African Swine Fever Virus from Wild Boar, Singapore, 2023
E. Y. Koh et al.
Source: Emerging Infectious Diseases Journal - September 14, 2023 Category: Infectious Diseases Source Type: research
C500 variants conveying complete mucosal immunity against fatal infections of pigs with Salmonella enterica serovar Choleraesuis C78-1 or F18+ Shiga toxin-producing Escherichia coli
Salmonella enterica serovar Choleraesuis (S. Choleraesuis) C500 strain is a live, attenuated vaccine strain that has been used in China for over 40 years to prevent piglet paratyphoid. However, this vaccine is limited by its toxicity and does not offer protection against diseases caused by F18+ Shiga toxin-producing Escherichia coli (STEC), which accounts for substantial economic losses in the swine industry. We recently generated a less toxic derivative of C500 strain with both asd and crp deletion (S. Choleraesuis C520) and assessed its efficacy in mice. In addition, we demonstrate that C520 is also less toxic in pigs an...
Source: Frontiers in Microbiology - September 14, 2023 Category: Microbiology Source Type: research
High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia
Vet Res. 2023 Sep 13;54(1):76. doi: 10.1186/s13567-023-01207-4.ABSTRACTDue to the increase in bacterial resistance, improving the anti-infectious immunity of the host is rapidly becoming a new strategy for the prevention and treatment of bacterial pneumonia. However, the specific lung immune responses and key immune cell subsets involved in bacterial infection are obscure. Actinobacillus pleuropneumoniae (APP) can cause porcine pleuropneumonia, a highly contagious respiratory disease that has caused severe economic losses in the swine industry. Here, using high-dimensional mass cytometry, the major immune cell repertoire i...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Na Li Junhui Zhu Peiru Chen Chuntong Bao Jun Wang Tamim Abdelaal Dexi Chen Sibo Zhu Wenjing Wang Jiangnan Mao Brendon P Scicluna Frits Koning Fengyang Li Liancheng Lei Source Type: research
