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Viruses, Vol. 15, Pages 1767: Dynamics of Infection of Atypical Porcine Pestivirus in Commercial Pigs from Birth to Market: A Longitudinal Study
This study improved our understanding of the infection dynamics of APPV in swine and the impact that the immune status and timing of infection have on the persistence of APPV in serum and tissues.
Source: Viruses - August 18, 2023 Category: Virology Authors: Alexandra C. Buckley Juan-Carlos Mora-D íaz Ronaldo L. Magtoto Amberly Van Hulzen Franco Matias Ferreyra Shollie M. Falkenberg Luis G. Gim énez-Lirola Bailey L. Arruda Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1765: Modeling the Seasonal Variation of Windborne Transmission of Porcine Reproductive and Respiratory Syndrome Virus between Swine Farms
This study confirms the usefulness of the HYSPLIT model as a tool when determining seasonal effects and distances and informs the near real-time risk of windborne PRRSv transmission that can be useful in future outbreak investigations and for implementing timely control measures.
Source: Viruses - August 18, 2023 Category: Virology Authors: Seunghyun Lim Andres M. Perez Kaushi S. T. Kanankege Tags: Article Source Type: research
Effects of monolaurin on intestinal barrier, blood biochemical profile, immunity, and antioxidant function in porcine epidemic diarrhea virus infected piglets
This study aimed to investigate its role in blood biochemical profile, intestinal barrier function, antioxidant function and the expression of antiviral genes in piglets infected with PEDV. Thirty-two piglets were randomly divided into four groups: control group, ML group, PEDV group and ML + PEDV group. Piglets were orally administrated with ML at a dose of 100 mg/kg·BW for 7 days before PEDV infection. Results showed that PEDV infection significantly decreased D-xylose content, and increased iFABP content, indicating that PEDV infection destroyed intestinal barrier and absorption function. While it could be repaired by ...
Source: The British Journal of Nutrition - August 17, 2023 Category: Nutrition Authors: Chao Wang Qian Zhang Changzheng Ji Yuyan Hu Dan Yi Tao Wu Lei Wang Di Zhao Yongqing Hou Source Type: research
Viruses, Vol. 15, Pages 1755: An Attempt of a New Strategy in PRV Prevention: Co-Injection with Inactivated Enterococcus faecium and Inactivated Pseudorabies Virus Intravenously
oufei Shi
Pseudorabies virus (PRV) is one of the causative agents of common infectious diseases in swine herds. Enterococcus faecium is a probiotic belonging to the group of lactic acid bacteria and has excellent immunomodulatory effects. Vaccine immunization is an important approach to prevent animal diseases in the modern farming industry, and good immunization outcomes can substantially reduce the damage caused by pathogens to animals, improve the quality of animals’ lives, and reduce economic losses. In the present study, we showed that inactivated E. faecium and inactivated PRV when co-injected intra...
Source: Viruses - August 17, 2023 Category: Virology Authors: Yuan Cui Libo Huang Jinlian Li Gang Wang Youfei Shi Tags: Article Source Type: research
Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine
Conclusions
This PIA model in swine could be used for research and development; objective benchmarking of agents, devices, and techniques; and in the training of neurointerventionalists.
Source: Journal of NeuroInterventional Surgery - August 17, 2023 Category: Neurosurgery Authors: Arturo Larco, J. L., Madhani, S. I., Liu, Y., Abbasi, M., Lylyk, P. N., Benike, A., Shahid, A., Tekin, B., Quinton, R., Savastano, L. E. Tags: Basic science Source Type: research
A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs
This study provides a useful tool to optimize the dosage regimen of cefquinome against respiratory tract infections and predicts the concentration of cefquinome residues in edible tissues. This information would be helpful to improve the food safety and guide rational drug usage.
Source: PLoS Computational Biology - August 16, 2023 Category: Biology Authors: Kun Mi Source Type: research
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts
In this study, we investigated if and how viruses from different (sub) families specifically affect m6A-containing host transcripts. Systematic analysis of host transcriptomes after infection with diverse types of viruses showed that m6A-methylated transcripts are selectively downregulated during infection with Sendai virus, African swine fever virus and the alphaherpesviruses herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV). Focusing on PRV and HSV-1, we found that downregulation of m6A-methylated transcripts depends on the YTHDF family of m6A-binding proteins, and correlates with localization of these proteins...
Source: Herpes - August 14, 2023 Category: Infectious Diseases Authors: Robert J J Jansens Anthony Olarerin-George Ruth Verhamme Aashiq Mirza Samie Jaffrey Herman W Favoreel Source Type: research
Identification of potential SLA-I-specific T-cell epitopes within the structural proteins of porcine deltacoronavirus
Int J Biol Macromol. 2023 Aug 12:126327. doi: 10.1016/j.ijbiomac.2023.126327. Online ahead of print.ABSTRACTPorcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that mainly threatens newborn piglets and poses a potential broad cross-species transmission risk. The antigenic epitopes of PDCoV are currently unidentified, and no information about T cell epitopes is available. Here, T-cell epitopes of PDCoV structural proteins were predicted using computational methods. 17 epitope peptides were synthesized and then screened using ELIspot, intracellular cytokine staining (ICS), and RT-qPCR detection...
Source: International Journal of Biological Macromolecules - August 14, 2023 Category: Biochemistry Authors: Yimin Wen Rui Chen Junpeng Yang Enbo Yu Weizhe Liu Yijie Liao Yiping Wen Rui Wu Qin Zhao Senyan Du Qigui Yan Xinfeng Han Sanjie Cao Xiaobo Huang Source Type: research
Oxidized Low-density Lipoproteins and Lipopolysaccharides Augment Carotid Artery Plaque Vulnerability in Hypercholesterolemic Microswine
This study aims to compare the potency of lipopolysaccharide (LPS) and oxidized low-density lipoproteins (oxLDL) to induce plaque formation and increase plaque vulnerability in the carotid artery of hypercholesterolemic Yucatan microswine. Atherosclerotic lesions at the common carotid artery junction and ascending pharyngeal artery were induced in hypercholesterolemic Yucatan microswine at 5-6 months of age with balloon angioplasty. LPS or oxLDL were administered intraluminally at the site of injury after occluding the arterial flow temporarily. Pre-intervention ultrasound (US), angiography, and optical coherence tomograph...
Source: Atherosclerosis - August 14, 2023 Category: Cardiology Authors: S Nooti V Rai M M Radwan F G Thankam H Singh Y S Chatzizisis D K Agrawal Source Type: research
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts
In this study, we investigated if and how viruses from different (sub) families specifically affect m6A-containing host transcripts. Systematic analysis of host transcriptomes after infection with diverse types of viruses showed that m6A-methylated transcripts are selectively downregulated during infection with Sendai virus, African swine fever virus and the alphaherpesviruses herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV). Focusing on PRV and HSV-1, we found that downregulation of m6A-methylated transcripts depends on the YTHDF family of m6A-binding proteins, and correlates with localization of these proteins...
Source: Herpes - August 14, 2023 Category: Infectious Diseases Authors: Robert J J Jansens Anthony Olarerin-George Ruth Verhamme Aashiq Mirza Samie Jaffrey Herman W Favoreel Source Type: research
Expression of ASFV p17 in CHO cells and identification of one novel epitope using a monoclonal antibody
Virus Res. 2023 Aug 12:199194. doi: 10.1016/j.virusres.2023.199194. Online ahead of print.ABSTRACTAs a highly pathogenic large DNA virus, African swine fever virus (ASFV) has huge particles and numerous encoded proteins. At present, few of the existing studies on ASFV proteins have investigated the function of p17. Specific antibodies against p17 to promote the development of prevention techniques against African swine fever (ASF) are urgently needed. Herein, we successfully expressed ASFV p17 in CHO cells using a suspension culture system and generated a monoclonal antibody (mAb) against p17. The mAb recognized a novel li...
Source: Virus Research - August 14, 2023 Category: Virology Authors: Liwei Li Sina Qiao Shumao Wang Jiachen Liu Kuan Zhao Yanjun Zhou Guoxin Li Yifeng Jiang Changlong Liu Guangzhi Tong Wu Tong Fei Gao Source Type: research
