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Condition: Diabetes Mellitus
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Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus-Evidence From the Literature
Dose Response. 2023 Sep 10;21(3):15593258231200527. doi: 10.1177/15593258231200527. eCollection 2023 Jul-Sep.ABSTRACTApart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and d...
Source: Dose Response - September 13, 2023 Category: Drugs & Pharmacology Authors: Saima Naz Mohsin Faiza Saleem Ayesha Humayun Afifa Tanweer Ambreen Muddassir Source Type: research
LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis
This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels in GDM mice were detected. The GDM mice were subjected to gain- and loss-of-function assays to examine the change of glucose metabolism indices (fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Yanli Xu Xiaodi Kang Huafang Liu Hongli Jiang Wenjing Wang Source Type: research
Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus-Evidence From the Literature
Dose Response. 2023 Sep 10;21(3):15593258231200527. doi: 10.1177/15593258231200527. eCollection 2023 Jul-Sep.ABSTRACTApart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and d...
Source: Dose Response - September 13, 2023 Category: Drugs & Pharmacology Authors: Saima Naz Mohsin Faiza Saleem Ayesha Humayun Afifa Tanweer Ambreen Muddassir Source Type: research
Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
Chlorogenic acid is a bioactive compound ubiquitously present in the natural realm, lauded for its salient anti-inflammatory and antioxidant attributes. It executes its anti-inflammatory function by moderating the synthesis and secretion of inflammatory mediators, namely, TNF-α, IL-1β, IL-6, IL-8, NO, and PGE2. Concurrently, it modulates key signaling pathways and associated factors, including NF-κB, MAPK, Nrf2, and others, bestowing protection upon cells and tissues against afflictions such as cardio-cerebrovascular and diabetes mellitus. Nevertheless, the inherent low bioavailability of chlorogenic acid poses challeng...
Source: Frontiers in Pharmacology - September 13, 2023 Category: Drugs & Pharmacology Source Type: research
Analysis of circulating ceramides and hexosylceramides in patients with coronary artery disease and type II diabetes mellitus
CONCLUSION: This study suggests that levels of circulating HexCers are downregulated in patients with CAD and concomitant DM compared to patients without DM. Further research is needed to investigate the underlying mechanisms and the suitability of HexCers as possible mediators and/or prognostic markers in CAD.PMID:37700226 | DOI:10.1186/s12872-023-03454-x
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Philip D üsing Nadine N Heinrich Baravan Al-Kassou Katharina Gutbrod Peter D örmann Georg Nickenig Felix Jansen Andreas Zietzer Source Type: research
Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis
CONCLUSIONS: We report a novel, familial GATA6 likely pathogenic variant associated with CHD, DM, and NEC with intestinal perforation. These findings expand the phenotypic spectrum of pathologic GATA6 variation to include intestinal abnormalities.IMPACT: Exome sequencing identified a novel heterozygous GATA6 variant (p.Cys468Tyr) that segregated in a family with CHD including persistent truncus arteriosus, atrial septal defects and bicuspid aortic valve. Additionally, affected members displayed extracardiac findings including childhood-onset diabetes mellitus, and uniquely, necrotizing enterocolitis with intestinal perfora...
Source: Pediatric Research - September 12, 2023 Category: Pediatrics Authors: Jun Yasuhara Sathiya N Manivannan Uddalak Majumdar David M Gordon Patrick J Lawrence Mona Aljuhani Katherine Myers Corey Stiver Amee M Bigelow Mark Galantowicz Hiroyuki Yamagishi Kim L McBride Peter White Vidu Garg Source Type: research
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
In this study, we aimed to assess risk factors for 30- and 60-day mortality in German lung cancer patients. In this retrospective cross-sectional analysis, we used data of lung cancer patients treated at LMU Hospital Munich between 2015 and 2019. We categorized patients into 30-day mortality, 60 day-mortality, and longer survival. We used Student's t-test and ANOVA to compare means and Chi2-test to compare frequencies. We used logistic regression analysis to identify factors associated with a risk for early mortality. Of the 2454 lung cancer patients, 2.0% (n = 50) died within 30 and 1.7% (n = 41) within 30 to 60 days of d...
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Amanda Tufman Sophie Schneiderbauer Julia Walter Blerina Resuli Diego Kauffmann-Guerrero Carlo M ümmler Pontus Mertsch Jeremias G ötschke Julia Kov ács Farkhad Manapov Christian Schneider Laura Sellmer Paola Arnold Volker Heinemann J ürgen Behr Daniel Source Type: research
Analysis of circulating ceramides and hexosylceramides in patients with coronary artery disease and type II diabetes mellitus
CONCLUSION: This study suggests that levels of circulating HexCers are downregulated in patients with CAD and concomitant DM compared to patients without DM. Further research is needed to investigate the underlying mechanisms and the suitability of HexCers as possible mediators and/or prognostic markers in CAD.PMID:37700226 | PMC:PMC10498560 | DOI:10.1186/s12872-023-03454-x
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Philip D üsing Nadine N Heinrich Baravan Al-Kassou Katharina Gutbrod Peter D örmann Georg Nickenig Felix Jansen Andreas Zietzer Source Type: research
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1-25.3), penis cancer (OR = 9.1; 95% CI 4.3-18.9), prostate cancer (OR = 2.0; 95% CI 1.6-2.4) and breast cancer (OR = 1.6; 95% CI 1.4-1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6-2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6-2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient treatment and follow-up of patients with LS. However, future studies are needed to confirm these results and the po...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Sandra Jerkovic Gulin Filippa Lundin Oliver Seifert Source Type: research
Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis
CONCLUSIONS: We report a novel, familial GATA6 likely pathogenic variant associated with CHD, DM, and NEC with intestinal perforation. These findings expand the phenotypic spectrum of pathologic GATA6 variation to include intestinal abnormalities.IMPACT: Exome sequencing identified a novel heterozygous GATA6 variant (p.Cys468Tyr) that segregated in a family with CHD including persistent truncus arteriosus, atrial septal defects and bicuspid aortic valve. Additionally, affected members displayed extracardiac findings including childhood-onset diabetes mellitus, and uniquely, necrotizing enterocolitis with intestinal perfora...
Source: Pediatric Research - September 12, 2023 Category: Pediatrics Authors: Jun Yasuhara Sathiya N Manivannan Uddalak Majumdar David M Gordon Patrick J Lawrence Mona Aljuhani Katherine Myers Corey Stiver Amee M Bigelow Mark Galantowicz Hiroyuki Yamagishi Kim L McBride Peter White Vidu Garg Source Type: research
Association of dietary and lifestyle inflammation score with type 2 diabetes mellitus and cardiometabolic risk factors in Iranian adults: Sabzevar Persian Cohort Study
In this study, we identified and recruited 619 patients with T2DM and 2113 without T2DM from 35-75 years old men and women in the baseline phase of the Sabzevar Persian Cohort Study. Using a validated 115-item semi-quantitative food frequency questionnaire, we calculated a 19-component DIS and a 3-component LIS weighted by circulating inflammation biomarkers. The DIS, LIS, and DLIS associations with diabetes were assessed by multivariable logistic regression analysis. Participants had a mean age of 48.29±8.53 (without T2DM: 47.66±8.42; T2DM: 50.44±8.57). Individuals in the highest compared to the lowest tertiles of DLIS...
Source: The British Journal of Nutrition - September 11, 2023 Category: Nutrition Authors: Farnush Bakhshimoghaddam Sima Jafarirad Elham Maraghi Fereshteh Ghorat Source Type: research
Overweight and obesity are associated with better survival in STEMI patients with diabetes
CONCLUSIONS: A U-shaped association governs the relationship between BMI and mortality in STEMI patients with diabetes, with those having overweight and obesity experiencing better survival.PMID:37691173 | DOI:10.1002/oby.23863
Source: Obesity - September 11, 2023 Category: Eating Disorders & Weight Management Authors: Hamza Chaudhry Ramez Bodair Ziyad Mahfoud Soha Dargham Jassim Al Suwaidi Hani Jneid Charbel Abi Khalil Source Type: research
Study of Auditory Brainstem Evoked Response at Varying Frequencies in Subclinical Hypothyroid Subjects
CONCLUSION: BERA study at 6 KHz and 80 dB detects central neuropathy earlier in subclinical hypothyroid patients.PMID:37694232 | PMC:PMC10492596 | DOI:10.4103/abr.abr_418_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Indira Jha Kabir Alam Kaushal K Keshari Niska Sinha Tarun Kumar Source Type: research
