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Condition: Diabetes Mellitus
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Profile of plasma free amino acids, carnitine and acylcarnitines, and JAK2 < sup > v617f < /sup > mutation as potential metabolic markers in children with type 1 diabetic nephropathy
Biomed Chromatogr. 2023 Sep 20:e5747. doi: 10.1002/bmc.5747. Online ahead of print.ABSTRACTFifty diabetic nephropathy (DN) children with type 1 diabetes mellitus (T1DM) and 50 healthy matched controls were included. Chromatographic assays of 14 amino acids, free carnitine and 27 carnitine esters using high-performance liquid chromatography/electrospray ionization-mass spectroscopy, and genetic testing for JAK2v617f mutation using real-time PCR were performed. Patients had significantly lower levels of tyrosine, branched-chain amino acids (BCAAs), and BCAA/AAA (aromatic chain amino acids) ratios, glycine, arginine, ornithin...
Source: Biomedical Chromatography : BMC - September 20, 2023 Category: Biomedical Science Authors: Mohammed H Hassan Omyma Galal Hala M Sakhr Eman B Kamaleldeen Nadia Farouk Zekry Ekram Fateen Rana Toghan Source Type: research
Association of serum phthalates exposure with incident type 2 diabetes risk in Chinese population: A nested case-control study
Ecotoxicol Environ Saf. 2023 Sep 18;265:115493. doi: 10.1016/j.ecoenv.2023.115493. Online ahead of print.ABSTRACTProspective epidemiological evidence was lacking on the association of phthalates (PAEs) exposure with incident type 2 diabetes mellitus (T2DM) risk. In present nested case-control study, we identified 1006 T2DM cases and matched 1006 controls based on Dongfeng-Tongji cohort study, and 6 PAEs were detected in baseline serum. The conditional logistic regression model, Bayesian kernel machine regression (BKMR) model and Quantile-based g-computation were applied to evaluate the associations of determined PAEs, eith...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Shiyang Zhang Xu Cheng Chengyong Jia Jun An Xin Zhang Peiwen Li Youbing Guan Yan Yan Zhuoya Zhao Yuenan Liu Tao Jing Meian He Source Type: research
Assessment of fibroblast growth factor 21 in children with type 1 diabetes mellitus in relation to microvascular complications
CONCLUSIONS: FGF21 is significantly higher among children with DM1 than in controls. However, its role in diabetic microvascular complica-tions needs further assessment.PMID:37728457 | PMC:PMC10411091 | DOI:10.5114/pedm.2022.121372
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Nermien Tantawy Eman Sherif Randa M Matter Nouran Salah Nour Eldin Abozeid Heba Atif Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Road map for personalized exercise medicine in T2DM
Trends Endocrinol Metab. 2023 Sep 18:S1043-2760(23)00166-2. doi: 10.1016/j.tem.2023.08.013. Online ahead of print.ABSTRACTThe number of patients with type 2 diabetes mellitus (T2DM) is rising at an alarming rate. Regular physical activity and exercise are cornerstones in the therapy of T2DM. While a one-size-fits-all approach fails to account for many between-subject differences, the use of personalized exercise medicine has the potential of optimizing health outcomes. Here, a road map for personalized exercise therapy targeted at patients with T2DM is presented. It considers secondary complications, glucose management, re...
Source: Trends in Endocrinology and Metabolism: TEM - September 20, 2023 Category: Endocrinology Authors: Christian Brinkmann Source Type: research
Hyperpolarized 1- < sup > 13 < /sup > Cpyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice
CONCLUSION: Agmatine influences the NADH/NAD+ redox state in the brains of T2DM mice, which may be connected with enhanced cognitive performance and increased conversion of HP [1-13C]pyruvate to HP [1-13C]lactate.PMID:37727922 | DOI:10.3349/ymj.2022.0554
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Young-Suk Choi Jae Eun Song Eosu Kim Chul Hoon Kim Jong Eun Lee Ho-Taek Song Source Type: research
Health of people with selected citizenships in Germany: prevalence of non-communicable diseases and associated social as well as migration-related factors
DISCUSSION: Given the importance of subjective sense of belonging to the society in Germany and self-reported experience of discrimination for the health outcomes studied, the results point to health inequalities among people with selected citizenships that may indicate mechanisms of social exclusion.PMID:37728772 | DOI:10.1007/s00103-023-03767-4
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 20, 2023 Category: International Medicine & Public Health Authors: Susanne Bartig Marleen Bug Carmen Koschollek Katja Kajikhina Miriam Blume Manuel Siegert Christin Heidemann Lena Walther Hannelore Neuhauser Claudia H övener Source Type: research
Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
Vet Q. 2023 Sep 20:1-20. doi: 10.1080/01652176.2023.2260442. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease. Our team's drug discovery program is investigating newly synthesized compounds that could dim...
Source: Veterinary Quarterly - September 20, 2023 Category: Veterinary Research Authors: Kendall B E Moore Natalie G Horgan Brooke Lenters Jessica S Fortin Source Type: research
Profile of plasma free amino acids, carnitine and acylcarnitines, and JAK2 < sup > v617f < /sup > mutation as potential metabolic markers in children with type 1 diabetic nephropathy
Biomed Chromatogr. 2023 Sep 20:e5747. doi: 10.1002/bmc.5747. Online ahead of print.ABSTRACTFifty diabetic nephropathy (DN) children with type 1 diabetes mellitus (T1DM) and 50 healthy matched controls were included. Chromatographic assays of 14 amino acids, free carnitine and 27 carnitine esters using high-performance liquid chromatography/electrospray ionization-mass spectroscopy, and genetic testing for JAK2v617f mutation using real-time PCR were performed. Patients had significantly lower levels of tyrosine, branched-chain amino acids (BCAAs), and BCAA/AAA (aromatic chain amino acids) ratios, glycine, arginine, ornithin...
Source: Biomedical Chromatography : BMC - September 20, 2023 Category: Biomedical Science Authors: Mohammed H Hassan Omyma Galal Hala M Sakhr Eman B Kamaleldeen Nadia Farouk Zekry Ekram Fateen Rana Toghan Source Type: research
Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
Vet Q. 2023 Sep 20:1-20. doi: 10.1080/01652176.2023.2260442. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease. Our team's drug discovery program is investigating newly synthesized compounds that could dim...
Source: Veterinary Quarterly - September 20, 2023 Category: Veterinary Research Authors: Kendall B E Moore Natalie G Horgan Brooke Lenters Jessica S Fortin Source Type: research
Control of diabetes mellitus and the risk of neointimal hyperplasia after percutaneous coronary intervention: Post-hoc analysis from the BLADE-PCI trial
CONCLUSIONS: Uncontrolled DM at the time of PCI performed with contemporary drug-eluting stents was not associated with an increased risk of NIH development.PMID:37726192 | DOI:10.1016/j.atherosclerosis.2023.117264
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Michael Jonas Philippe Genereux Akiko Maehara Ori Ben-Yehuda Gregg W Stone Gil Chernin Source Type: research
Maintaining renin-angiotensin-aldosterone system inhibitor treatment with patiromer in hyperkalaemic chronic kidney disease patients: comparison of a propensity-matched real-world population with AMETHYST-DN
CONCLUSIONS: These results demonstrate the benefit of patiromer for sK+ management to enable RAASi use, while revealing beneficial effects on BP.PMID:37725919 | DOI:10.1159/000533753
Source: American Journal of Nephrology - September 19, 2023 Category: Urology & Nephrology Authors: Rajkumar Chinnadurai Sharmilee Rengarajan Jeffrey J Budden Carol Moreno Quinn Philip A Kalra Source Type: research
Error traps in the perioperative management of children with type 1 diabetes
This article reviews common errors of associated with the perioperative management of patients with T1D, including failure to assess and coordinate patient care preoperatively; failure to understand diabetes management and technology; failure to monitor blood glucose and recognize dysglycemia; and failure to appropriately administer basal insulin.PMID:37724489 | DOI:10.1111/pan.14763
Source: Paediatric Anaesthesia - September 19, 2023 Category: Anesthesiology Authors: M Hoagland B Duggar J Hamrick G Todd Alonso L Martin Source Type: research
The Intersocietal IWGDF, ESVS, SVS Guidelines on Peripheral Artery Disease in People With Diabetes Mellitus and a Foot Ulcer
Eur J Vasc Endovasc Surg. 2023 Sep 6:S1078-5884(23)00586-5. doi: 10.1016/j.ejvs.2023.07.020. Online ahead of print.ABSTRACTDiabetes related foot complications have become a major cause of morbidity and are implicated in most major and minor amputations globally. Approximately 50% of people with diabetes and a foot ulcer have peripheral artery disease (PAD) and the presence of PAD significantly increases the risk of adverse limb and cardiovascular events. The International Working Group on the Diabetic Foot (IWGDF) has published evidence based guidelines on the management and prevention of diabetes related foot complication...
Source: PubMed: Eur J Vasc Endovasc ... - September 19, 2023 Category: Surgery Authors: Robert Fitridge Vivienne Chuter Joseph Mills Robert Hinchliffe Nobuyoshi Azuma Christian-Alexander Behrendt Edward J Boyko Michael S Conte Misty Humphries Lee Kirksey Katharine C McGinigle Sigrid Nikol Joakim Nordanstig Vincent Rowe David Russell Jos C va Source Type: research
Finerenone (Kerendia) for the Treatment of Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus
Am Fam Physician. 2023 Sep;108(3):305-306.NO ABSTRACTPMID:37725467
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Autumn Stewart-Lynch Source Type: research
