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Condition: Diabetes Mellitus
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Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Health profile of workers from different industries in Singapore
CONCLUSION: Health issues are prevalent in the workforce and may affect work and employee safety. It is increasingly important for employees' health to be considered in risk assessments and prioritised in workplace safety and health management systems and strategies. Health promotion interventions should be targeted, and multilevel and multicomponent initiatives should be integrated with pre-existing occupational safety programmes.PMID:37721304 | DOI:10.4103/singaporemedj.SMJ-2021-414
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sin Eng Chia Mei Ling Tan Elise Cheok Peh Woon Ong Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research Bulletin - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Exploration of the anti-diabetic potential of hydro-ethanolic leaf extract of Koenigia polystachya L.: an edible wild plant from Northeastern India
CONCLUSIONS: Based on the outcomes of this study, the HELeKP-treated rats have significant free radical scavenging and anti-diabetic potential. Therefore, it can be recommended as a beneficial functional vegetable for consumption.PMID:37723570 | PMC:PMC10506326 | DOI:10.1186/s42826-023-00174-3
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Alokali Kiba Dipankar Saha Bhrigu Kumar Das Source Type: research
Clinical and Epidemiological Profile of Herpes Zoster and Its Complications in a Tertiary Care Center of Bihar: A Prospective Study
Conclusion A broader understanding of the clinical and epidemiological factors of herpes zoster and post-herpetic complications is important as this disease constitutes a considerable burden in a tertiary care center and if not treated adequately, the after-effects might last for many years altogether. Hence, early diagnosis and initiation of adequate antiviral therapy as well as pain management is the key aspect of management.PMID:37719532 | PMC:PMC10503883 | DOI:10.7759/cureus.43560
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Rajesh Sinha Pinki Kumari U K Pallavi Subhasree Sarkar Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Health profile of workers from different industries in Singapore
CONCLUSION: Health issues are prevalent in the workforce and may affect work and employee safety. It is increasingly important for employees' health to be considered in risk assessments and prioritised in workplace safety and health management systems and strategies. Health promotion interventions should be targeted, and multilevel and multicomponent initiatives should be integrated with pre-existing occupational safety programmes.PMID:37721304 | DOI:10.4103/singaporemedj.SMJ-2021-414
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sin Eng Chia Mei Ling Tan Elise Cheok Peh Woon Ong Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Molecular docking analysis of calcium channel blockers with ALR2 and RAGE
We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.PMID:37720280 | PMC:PMC10504517 | DOI:10.6026/97320630019028
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Samreen Kazmi Surekha Challa Malini Devi Alaparthi Indira Devi M Swetha Sudha Nagamalla Priya Ej Source Type: research
Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
Immunobiology. 2023 Sep 13;228(6):152745. doi: 10.1016/j.imbio.2023.152745. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats. Thirty rats were divided into six groups, including a control group, MIIT, HIIT, DM, DM + MIIT, and DM + HIIT (n = 5 ...
Source: Immunobiology - September 18, 2023 Category: Allergy & Immunology Authors: Reza Sheikh Saeid Shakerian Seyed Reza Fatemi Tabatabaei Abdolhamid Habibi Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research Bulletin - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
Immunobiology. 2023 Sep 13;228(6):152745. doi: 10.1016/j.imbio.2023.152745. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats. Thirty rats were divided into six groups, including a control group, MIIT, HIIT, DM, DM + MIIT, and DM + HIIT (n = 5 ...
Source: Immunobiology - September 18, 2023 Category: Allergy & Immunology Authors: Reza Sheikh Saeid Shakerian Seyed Reza Fatemi Tabatabaei Abdolhamid Habibi Source Type: research
Molecular docking analysis of calcium channel blockers with ALR2 and RAGE
We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.PMID:37720280 | PMC:PMC10504517 | DOI:10.6026/97320630019028
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Samreen Kazmi Surekha Challa Malini Devi Alaparthi Indira Devi M Swetha Sudha Nagamalla Priya Ej Source Type: research
Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy
Light Sci Appl. 2023 Sep 18;12(1):231. doi: 10.1038/s41377-023-01275-3.ABSTRACTBeing the largest and most accessible organ of the human body, the skin could offer a window to diabetes-related complications on the microvasculature. However, skin microvasculature is typically assessed by histological analysis, which is not suited for applications to large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) for precise, non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy, resolved with unprecedented sensitivity and det...
Source: Appl Human Sci - September 17, 2023 Category: Physiology Authors: Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin F üchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Source Type: research
