Filtered By:
Condition: Diabetes Mellitus
This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 39189 results found since Jan 2013.
Development and characterization of polydeoxyribonucleotide (PDRN) loaded chitosan polyplex: In vitro and in vivo evaluation of wound healing activity
Int J Biol Macromol. 2023 Sep 7:126729. doi: 10.1016/j.ijbiomac.2023.126729. Online ahead of print.ABSTRACTPolydeoxyribonucleotide (PDRN) is an accelerated diabetic wound healing therapy with promising abilities to promote cell growth, angiogenesis, collagen synthesis, and reduce inflammation where its sustainable delivery and release behavior is critical to ensure effective wound healing properties. Therefore, a nanopolyplex was developed here, by encapsulating PDRN with chitosan to affirm its delivery systematically. The physicochemical characterization revealed its successful encapsulation which facilitates the gradual ...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: S H S Dananjaya K G P Madushani Jeewani Dilrukshi Nayomi D De Silva W M Gayashani Sandamalika Dukgyu Kim Dongrack Choi Mahanama De Zoysa Anoja P Attanayake Source Type: research
Temperature-sensitive hydrogel dressing loaded with nicotinamide mononucleotide accelerating wound healing in diabetic mice
Biomed Pharmacother. 2023 Sep 7;167:115431. doi: 10.1016/j.biopha.2023.115431. Online ahead of print.ABSTRACTDiabetic foot ulcers, a common complication of diabetes mellitus, significantly impact patients' quality of life and impose a substantial economic burden on healthcare systems. However, the currently used treatments are associated with various challenges and the traditionally used dressings lack functional efficacy. Oxidative stress is believed to play a vital role in diabetic wound healing. Therefore, nicotinamide mononucleotide (NMN), which is known for its antioxidant properties, offers the potential to accelerat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2023 Category: Drugs & Pharmacology Authors: Yue Liang Min Li Yuan Tang Jinlong Yang Jing Wang Yuqi Zhu Huitong Liang Qinru Lin Yipen Cheng Xinyi Yang Huanzhang Zhu Source Type: research
Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Atrial Myocardium and Coronary Perivascular Adipose Tissue
Int J Mol Sci. 2023 Aug 31;24(17):13552. doi: 10.3390/ijms241713552.ABSTRACTEndothelial (EL) and lipoprotein (LPL) lipases are enzymes involved in lipoproteins metabolism and formation of atherosclerosis, a pathological feature of coronary artery disease (CAD). This paper examines the role of the lipases in the right atrial appendage (RAA) and coronary perivascular adipose tissue (PVAT) of patients with CAD alone or with accompanying diabetes. Additionally, correlation analysis for plasma concentration of the lipases, apolipoproteins (ApoA-ApoJ) and blood lipids (Chol, HDL-C, LDL-C, TAG) was performed. We observed that CAD...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Ma łgorzata Knapp Bart łomiej Łukaszuk Anna Lisowska Tomasz Hirnle Jan G órski Adrian Chabowski Agnieszka Mik łosz Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | PMC:PMC10492310 | DOI:10.1186/s12981-023-00564-6
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research
Development and characterization of polydeoxyribonucleotide (PDRN) loaded chitosan polyplex: In vitro and in vivo evaluation of wound healing activity
Int J Biol Macromol. 2023 Sep 7:126729. doi: 10.1016/j.ijbiomac.2023.126729. Online ahead of print.ABSTRACTPolydeoxyribonucleotide (PDRN) is an accelerated diabetic wound healing therapy with promising abilities to promote cell growth, angiogenesis, collagen synthesis, and reduce inflammation where its sustainable delivery and release behavior is critical to ensure effective wound healing properties. Therefore, a nanopolyplex was developed here, by encapsulating PDRN with chitosan to affirm its delivery systematically. The physicochemical characterization revealed its successful encapsulation which facilitates the gradual ...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: S H S Dananjaya K G P Madushani Jeewani Dilrukshi Nayomi D De Silva W M Gayashani Sandamalika Dukgyu Kim Dongrack Choi Mahanama De Zoysa Anoja P Attanayake Source Type: research
Clinical Significance of Radical Prostatectomy in Clinical Lymph Node Metastasis in Prostate Cancer
CONCLUSION: Radical prostatectomy can confirm lymph node metastasis. Although pathologic diagnosis has no effect on time to BCR and CPRC, because it affects BCR rate, CRPC rate, and CSS, an accurate pathological diagnosis obtained through surgery is beneficial in the treatment of clinical lymph node metastasis prostate cancer.PMID:37689608 | DOI:10.1245/s10434-023-14137-4
Source: Ann Oncol - September 9, 2023 Category: Cancer & Oncology Authors: Dongwon Kim Bumjin Lim Jungyo Suh Dalsan You In Gab Jeong Jun Hyuk Hong Hanjong Ahn Source Type: research
Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus
CONCLUSION: Dysbiosis of the gut microbiota may increase leptin expression and cause GDM. Oral probiotics enhance Treg, Tfr, and Breg cells, which limit the inflammatory response and assist mice in sustaining normal pregnancy. Thus, oral probiotics may prevent GDM, enabling targeted gut microbiota modulation and maternal and fetal health.PMID:37684563 | DOI:10.1186/s10020-023-00716-4
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Weijie Liang Yuanyi Feng Dongmei Yang Jiajun Qin Ximei Zhi Wen Wu Qiang Jie Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 < sup > + < /sup > /CaMK2 signaling pathway
Mol Med Rep. 2023 Oct;28(4):197. doi: 10.3892/mmr.2023.13084. Epub 2023 Sep 8.ABSTRACTVascular endothelial growth factor B (VEGFB) plays a crucial role in glucolipid metabolism and is highly associated with type 2 diabetes mellitus (T2DM). The role of VEGFB in the insulin secretion of β cells remains unverified. Thus, the present study aimed to discuss the effect of VEGFB on regulating insulin secretion in T2DM development, and its underlying mechanism. A high‑fat diet and streptozocin (STZ) were used for inducing T2DM in mice model, and VEGFB gene in islet cells of T2DM mice was knocked out by CRISPR Cas9 and overexpre...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Yuqi Li Rongrong Li Xu Luo Fang Xu Meizi Yang Lanhui Zheng Qihao Wu Wenguo Jiang Yana Li Source Type: research
Retracted: Significance of Edaravone Combined with Emotion Management Model in Promoting the Recovery Process and Improving Negative Psychology in Patients with Type 2 Diabetes Mellitus Combined with Stroke
Biomed Res Int. 2023 Aug 30;2023:9845187. doi: 10.1155/2023/9845187. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/8099997.].PMID:37680301 | PMC:PMC10482530 | DOI:10.1155/2023/9845187
Source: Biomed Res - September 8, 2023 Category: Research Authors: BioMed Research International Source Type: research
Serum sclerostin level is positively associated with endothelial dysfunction measured by digital thermal monitoring in patients with type 2 diabetes: A prospective cross-sectional study
This study aimed to assess the correlation of sclerostin and DKK1 concentrations with endothelial function measured using vascular reactivity index (VRI) in patients with type 2 diabetes mellitus (T2DM). Fasting blood samples were collected from 100 patients with T2DM. Endothelial function and VRI were measured using digital thermal monitoring and circulating sclerostin and DKK1 levels by enzyme-linked immunosorbent assays. VRI values < 1.0, 1.0-1.9, and > 2.0 indicated poor, intermediate, and good vascular reactivity, respectively. Overall, 30, 38, and 32 patients had poor, intermediate, and good vascular reactivity...
Source: Atherosclerosis - September 8, 2023 Category: Cardiology Authors: Bang-Gee Hsu Du-An Wu Hsin-Yu Yang Ming-Chun Chen Source Type: research
Selection for antimicrobial prophylaxis in emergency and elective transurethral procedures: Susceptibility pattern in T ürkiye
CONCLUSION: We found that currently recommended antimicrobials provide poor coverage for the most common pathogens isolated. Urologists should consider patient-based antibiotic prophylaxis in endoscopic urethral procedures, follow appropriate proto-cols, and consider local antibiotic resistance.PMID:37681729 | DOI:10.14744/tjtes.2023.99663
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - September 8, 2023 Category: Emergency Medicine Authors: Tanju Keten Melih Balci Ünsal Eroğlu Ali Yasin Özercan Şeref Coşer Serdar Ba şboğa Koray Tatl ıcı Anil Erkan Çağdaş Şenel Remzi Salar Özer Güzel Y ılmaz Aslan Altug Tuncel Ali Atan Source Type: research
Elevated HbA1c level associated with disease severity and surgical extension in diabetic foot patients
CONCLUSION: The results of this study showed that as HbA1c values at diagnosis increased in patients with diabetic foot; Wagner/PEDIS grades, disease severity, surgical extension, amputation level, and tissue loss increased. To reduce the severity of diabetic foot disease and prevent amputation, compliance with diabetic treatment and glycemic control should be increased.PMID:37681727 | DOI:10.14744/tjtes.2023.08939
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - September 8, 2023 Category: Emergency Medicine Authors: Simay Aky üz Adile Beg üm Bahçecioğlu Mutlu H Erhan Guven Ali Murat Ba şak Kerim Bora Yilmaz Source Type: research
Role of transcription factor FOXM1 in diabetes and its complications (Review)
Int J Mol Med. 2023 Nov;52(5):101. doi: 10.3892/ijmm.2023.5304. Epub 2023 Sep 8.ABSTRACTDiabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biolog...
Source: International Journal of Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Baoqing Zhao Mengxi Li Yanting Su Shigang Shan Wenbin Qian Dan Zhu Xiufen Liu Zhenwang Zhang Source Type: research
The holistic maternity care needs of women with Gestational Diabetes Mellitus: A systematic review with thematic synthesis
CONCLUSIONS: The provision of holistic models of care for this cohort is pivotal to improving clinical outcomes and the experiences of women with GDM.PMID:37684120 | DOI:10.1016/j.wombi.2023.08.005
Source: Women Birth - September 8, 2023 Category: Midwifery Authors: Deborah Davis Ella Kurz Mary-Ellen Hooper Marjorie Atchan Sarah Spiller Julie Blackburn Mary Bushell Vivienne Lewis Myra Leung Indira Samarawickrema Cathy Knight-Agarwal Source Type: research
