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Condition: Hypertension
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Mitochondria Derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension
Am J Respir Cell Mol Biol. 2023 Sep 15. doi: 10.1165/rcmb.2023-0010OC. Online ahead of print.ABSTRACTIncreasing evidence suggests that mitochondrial dysfunction in pulmonary endothelial cells (ECs) plays a causative role in the initiation and progression of pulmonary hypertension (PH); how mitochondria become dysfunctional in PH remains elusive. Mitochondria-derived vesicles (MDVs) are small subcellular vesicles that excise from mitochondria. Whether or not MDVs deregulation causes mitochondrial dysfunction in PH is unknown. This aim of this study was to determine MDVs regulation in ECs and to elucidate how MDVs deregulati...
Source: Am J Respir Cell Mol... - September 15, 2023 Category: Respiratory Medicine Authors: Qiang Zhao Zhixue Liu Ping Song Zuyi Yuan Ming-Hui Zou Source Type: research
Recommended assessment and management of sleep disordered breathing in patients with atrial fibrillation, hypertension and heart failure: Taiwan Society of Cardiology/Taiwan Society of sleep Medicine/Taiwan Society of pulmonary and Critical Care Medicine joint consensus statement
J Formos Med Assoc. 2023 Sep 13:S0929-6646(23)00338-8. doi: 10.1016/j.jfma.2023.08.024. Online ahead of print.ABSTRACTSleep disordered breathing (SDB) is highly prevalent and may be linked to cardiovascular disease in a bidirectional manner. The Taiwan Society of Cardiology, Taiwan Society of Sleep Medicine and Taiwan Society of Pulmonary and Critical Care Medicine established a task force of experts to evaluate the evidence regarding the assessment and management of SDB in patients with atrial fibrillation (AF), hypertension and heart failure with reduced ejection fraction (HFrEF). The GRADE process was used to assess the...
Source: J Formos Med Assoc - September 15, 2023 Category: General Medicine Authors: Pei-Lin Lee Yen-Wen Wu Hao-Min Cheng Cheng-Yi Wang Li-Pang Chuang Chou-Han Lin Liang-Wen Hang Chih-Chieh Yu Chung-Lieh Hung Ching-Lung Liu Kun-Ta Chou Mao-Chang Su Kai-Hung Cheng Chun-Yao Huang Charles Jia-Yin Hou Kuo-Liang Chiu Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
Characteristics and Predictors of Apparent Treatment Resistant Hypertension in Real-World Populations Using Electronic Health Record-Based Data
CONCLUSIONS: In two large, diverse real-world populations, we observed similar comorbidities and predictors of aTRH as prior studies. In the future, these results may be used to improve healthcare professionals' understanding of aTRH predictors and associated comorbidities.PMID:37712350 | DOI:10.1093/ajh/hpad084
Source: American Journal of Hypertension - September 15, 2023 Category: Cardiology Authors: Eissa Jafari Rhonda M Cooper-DeHoff Mark B Effron William R Hogan Caitrin W McDonough Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
Biomed Environ Sci. 2023 Aug 20;36(8):669-701. doi: 10.3967/bes2023.106.ABSTRACTIn the past 30 years, the accessibility and quality index of medical care have made remarkable progress in China, ranking the first among middle-income countries. Many cardiovascular technologies are at or near the world's leading level, and significant progress has been achieved in China solving the problem of "treatment difficulty" of cardiovascular diseases (CVD). However, due to the prevalence of unhealthy lifestyles among Chinese residents, a huge population with CVD risk factors, accelerated population aging, and other reasons, the incide...
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Writing Committee Of The Report On Cardiovascular Health And Diseases In China The Source Type: research
Recommended assessment and management of sleep disordered breathing in patients with atrial fibrillation, hypertension and heart failure: Taiwan Society of Cardiology/Taiwan Society of sleep Medicine/Taiwan Society of pulmonary and Critical Care Medicine joint consensus statement
J Formos Med Assoc. 2023 Sep 13:S0929-6646(23)00338-8. doi: 10.1016/j.jfma.2023.08.024. Online ahead of print.ABSTRACTSleep disordered breathing (SDB) is highly prevalent and may be linked to cardiovascular disease in a bidirectional manner. The Taiwan Society of Cardiology, Taiwan Society of Sleep Medicine and Taiwan Society of Pulmonary and Critical Care Medicine established a task force of experts to evaluate the evidence regarding the assessment and management of SDB in patients with atrial fibrillation (AF), hypertension and heart failure with reduced ejection fraction (HFrEF). The GRADE process was used to assess the...
Source: J Formos Med Assoc - September 15, 2023 Category: General Medicine Authors: Pei-Lin Lee Yen-Wen Wu Hao-Min Cheng Cheng-Yi Wang Li-Pang Chuang Chou-Han Lin Liang-Wen Hang Chih-Chieh Yu Chung-Lieh Hung Ching-Lung Liu Kun-Ta Chou Mao-Chang Su Kai-Hung Cheng Chun-Yao Huang Charles Jia-Yin Hou Kuo-Liang Chiu Source Type: research
The clinical predictive value and regulation mechanism of microRNA-188-5p in contrast-induced acute kidney injury
Biochem Biophys Res Commun. 2023 Sep 10;679:215-223. doi: 10.1016/j.bbrc.2023.09.019. Online ahead of print.ABSTRACTContrast-induced acute kidney injury (CI-AKI), also known as contrast-induced nephropathy (CIN), has become the third leading cause of iatrogenic AKI. Serum creatinine (Scr) is currently used in CIN clinical diagnosis. Patients with increased Scr have developed severe kidney injury, so there is an urgent need to find a bio-marker for CIN early diagnosis. To investigate the changes in circulating microRNA-188-5p (miR-188-5p) after coronary angiography and its predictive value for the CIN occurrence, miR-188-5p...
Source: Biochemical and Biophysical Research communications - September 15, 2023 Category: Biochemistry Authors: Ran Yu Caixia Wu Yao Xiao Qingju Li Jiajia Chen Jian Song Haoyu Chen Zhengqian Wang Wanpeng Wang Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
Circulating Proteins and Mortality in CKD: A Proteomics Study of the AASK and ARIC Cohorts
CONCLUSIONS: Using large-scale proteomic analysis, proteins were reproducibly associated with mortality in 2 cohorts of participants with CKD.PLAIN-LANGUAGE SUMMARY: Patients with chronic kidney disease (CKD) have a high risk of premature death, with various pathophysiological processes contributing to this increased risk of mortality. This observational cohort study aimed to investigate the associations between circulating proteins and all-cause mortality in patients with CKD using large-scale proteomic analysis. The study analyzed data from the African American Study of Kidney Disease and Hypertension (AASK) study and va...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Nityasree Srialluri Aditya Surapaneni Pascal Schlosser Teresa K Chen Insa M Schmidt Eugene P Rhee Josef Coresh Morgan E Grams Source Type: research
Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review
Front Cardiovasc Med. 2023 Aug 30;10:1250263. doi: 10.3389/fcvm.2023.1250263. eCollection 2023.ABSTRACTThe dysbiosis of the oral microbiome and vascular translocation of the periodontopathic microorganism to peripheral blood can cause local and systemic extra-oral inflammation. Microorganisms associated with the subgingival biofilm are readily translocated to the peripheral circulation, generating bacteremia and endotoxemia, increasing the inflammation in the vascular endothelium and resulting in endothelial dysfunction. This review aimed to demonstrate how the dysbiosis of the oral microbiome and the translocation of oral...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Diego F Gualtero Gloria In és Lafaurie Diana Marcela Buitrago Yormaris Castillo Paula Katherine Vargas-Sanchez Diana Marcela Castillo Source Type: research
Characteristics and Predictors of Apparent Treatment Resistant Hypertension in Real-World Populations Using Electronic Health Record-Based Data
CONCLUSIONS: In two large, diverse real-world populations, we observed similar comorbidities and predictors of aTRH as prior studies. In the future, these results may be used to improve healthcare professionals' understanding of aTRH predictors and associated comorbidities.PMID:37712350 | DOI:10.1093/ajh/hpad084
Source: American Journal of Hypertension - September 15, 2023 Category: Cardiology Authors: Eissa Jafari Rhonda M Cooper-DeHoff Mark B Effron William R Hogan Caitrin W McDonough Source Type: research
Mitochondria Derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension
Am J Respir Cell Mol Biol. 2023 Sep 15. doi: 10.1165/rcmb.2023-0010OC. Online ahead of print.ABSTRACTIncreasing evidence suggests that mitochondrial dysfunction in pulmonary endothelial cells (ECs) plays a causative role in the initiation and progression of pulmonary hypertension (PH); how mitochondria become dysfunctional in PH remains elusive. Mitochondria-derived vesicles (MDVs) are small subcellular vesicles that excise from mitochondria. Whether or not MDVs deregulation causes mitochondrial dysfunction in PH is unknown. This aim of this study was to determine MDVs regulation in ECs and to elucidate how MDVs deregulati...
Source: American Journal of Respiratory Cell and Molecular Biology - September 15, 2023 Category: Molecular Biology Authors: Qiang Zhao Zhixue Liu Ping Song Zuyi Yuan Ming-Hui Zou Source Type: research
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies
CONCLUSION: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.PMID:37712242 | DOI:10.4415/ANN_23_03_10
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Mihaela Jurdana Lovro Žiberna Source Type: research
Mitochondria Derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension
Am J Respir Cell Mol Biol. 2023 Sep 15. doi: 10.1165/rcmb.2023-0010OC. Online ahead of print.ABSTRACTIncreasing evidence suggests that mitochondrial dysfunction in pulmonary endothelial cells (ECs) plays a causative role in the initiation and progression of pulmonary hypertension (PH); how mitochondria become dysfunctional in PH remains elusive. Mitochondria-derived vesicles (MDVs) are small subcellular vesicles that excise from mitochondria. Whether or not MDVs deregulation causes mitochondrial dysfunction in PH is unknown. This aim of this study was to determine MDVs regulation in ECs and to elucidate how MDVs deregulati...
Source: Am J Respir Cell Mol... - September 15, 2023 Category: Respiratory Medicine Authors: Qiang Zhao Zhixue Liu Ping Song Zuyi Yuan Ming-Hui Zou Source Type: research
