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Condition: Hypertension
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Total 62632 results found since Jan 2013.
Heart rate variability and cardiovascular risk factors in patients with rheumatoid arthritis: A longitudinal study
CONCLUSION: This study showed that patients with RA have autonomic imbalance both at an early stage of the disease and after five years, despite anti-rheumatic medication, but no correlation between HRV and inflammation markers were observed. Reduced HRV was also significantly negatively correlated with increased SBP. Hypertension is a common finding in patients with RA. Thus, significant decline of HRV could be a useful early marker for development of hypertension in patients with RA.PMID:37703773 | DOI:10.1016/j.autneu.2023.103119
Source: Autonomic Neuroscience - September 13, 2023 Category: Neuroscience Authors: Sofia Erelund Anna S ödergren Urban Wiklund Nina Sundstr öm Source Type: research
Medium-Term Weight Loss and Remission of Comorbidities Following Endoscopic Sleeve Gastroplasty: a Systematic Review and Meta-analysis
AbstractThis systematic review and meta-analysis aimed to determine the short- and medium-term weight loss outcomes and comorbidity resolution following endoscopic sleeve gastroplasty. Our search identified 35 relevant studies containing data from 7525 patients. Overall, pooled short-term (12 months) total weight loss (TWL) was 16.2% (95% CI 13.1 –19.4%) in 23 studies (n = 5659). Pooled medium-term TWL was 15.4% (95% CI 13.7 –17.2%) in 10 studies (n = 4040). Diabetes resolution was 55.4% (95% CI 46 –64%), hypertension resolution was 62.8% (95% CI 43–82%), dyslipidaemia resolution was 56.3% (95% CI 49–63%), and ob...
Source: Obesity Surgery - September 13, 2023 Category: Surgery Source Type: research
The significance of serum Klotho to hearing loss: a potential protector under noise pollution
In conclusion, a lower level of serum Klotho was found to be associated with increased hearing thresholds, particularly among the elderly population. This finding has significant implications for the prevention and treatment of hearing damage.PMID:37700133 | DOI:10.1007/s11356-023-29788-9
Source: Environmental Science and Pollution Research International - September 12, 2023 Category: Environmental Health Authors: Jingcheng Zhou Zheqi Fan Yiming Bi Dingchang Li Xuemin Chen Kun Hou Shuaifei Ji Source Type: research
Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
CONCLUSIONS: SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.PMID:37698017 | DOI:10.1161/CIRCRESAHA.123.322740
Source: Circulation Research - September 12, 2023 Category: Cardiology Authors: A Dushani C U Ranasinghe Maggie Holohan Kalyn M Borger Deborah L Donahue Rafael D Kuc Martin Gerig Andrew Kim Victoria A Ploplis Francis J Castellino Margaret A Schwarz Source Type: research
Pharmacotherapy of refractory Pulmonary arterial hypertension
Expert Opin Pharmacother. 2023 Sep 12. doi: 10.1080/14656566.2023.2257134. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of refractory pulmonary arterial hypertension (PAH) is challenging and rarely the focus of reviews. The purpose of this review is to discuss current treatment options of refractory PAH, along with the state of research of several new medications.AREAS COVERED: We conducted a comprehensive PubMed search on the relevant literature on treating PAH, with a focus on approved and investigational interventions for high-risk patients. Our strategy used keywords 'Treatment' AND 'Pulmonary Hypertension,' w...
Source: Expert Opinion on Pharmacotherapy - September 12, 2023 Category: Drugs & Pharmacology Authors: Mahmoud Samy Ahmed Muhammad Ghallab Talia Ostrow Mouhamed Nashawi Zakaria Alagha Avi Levine Wilbert S Aronow Gregg M Lanier Source Type: research
Immunoregulation mechanism of VEGF signaling pathway inhibitors and its efficacy on the kidney
Am J Med Sci. 2023 Sep 10:S0002-9629(23)01330-7. doi: 10.1016/j.amjms.2023.09.005. Online ahead of print.ABSTRACTAngiogenesis and immunosuppression are closely related pathophysiologic processes. Widely prescribed in malignant tumor and proliferative retinal lesions, VEGF signaling pathway inhibitors may cause hypertension and renal injury in some patients, presenting with proteinuria, nephrotic syndrome, renal failure and thrombotic microangiopathy. VEGF signaling pathway inhibitors block the action of both VEGF-A and VEGF-C. However, VEGF-A and VEGF-C produced by podocytes are vital to maintain the physiological function...
Source: The American Journal of the Medical Sciences - September 12, 2023 Category: General Medicine Authors: Jun Li Xiao-Lin Li Chun-Qing Li Source Type: research
Pharmacotherapy of refractory pulmonary arterial hypertension
Expert Opin Pharmacother. 2023 Sep 12:1-14. doi: 10.1080/14656566.2023.2257134. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of refractory pulmonary arterial hypertension (PAH) is challenging and rarely the focus of reviews. The purpose of this review is to discuss current treatment options of refractory PAH, along with the state of research of several new medications.AREAS COVERED: We conducted a comprehensive PubMed search on the relevant literature on treating PAH, with a focus on approved and investigational interventions for high-risk patients. Our strategy used keywords 'Treatment' AND 'Pulmonary Hypertensio...
Source: Expert Opinion on Pharmacotherapy - September 12, 2023 Category: Drugs & Pharmacology Authors: Mahmoud Samy Ahmed Muhammad Ghallab Talia Ostrow Mouhamed Nashawi Zakaria Alagha Avi Levine Wilbert S Aronow Gregg M Lanier Source Type: research
Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
CONCLUSIONS: SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.PMID:37698017 | DOI:10.1161/CIRCRESAHA.123.322740
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: A Dushani C U Ranasinghe Maggie Holohan Kalyn M Borger Deborah L Donahue Rafael D Kuc Martin Gerig Andrew Kim Victoria A Ploplis Francis J Castellino Margaret A Schwarz Source Type: research
Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus: A meta-analysis
CONCLUSION: PAH is a serious complication of SLE. Since prognosis of SLE patients after the occurrence of PAH is poor, routine examination should be conducted for SLE patients with PAH risk factors.PMID:37699157 | DOI:10.1177/09612033231202398
Source: Lupus - September 12, 2023 Category: Rheumatology Authors: Yuqi Liu Zhen Cheng Bowen Zha Xiaodong Chen Zhiyu Gong Lang Ji Lingling Wei Source Type: research
Quality of life, fatigue, sleep quality, and mental health in systemic lupus erythematosus patients with a high cardiovascular risk profile
Lupus. 2023 Sep 12:9612033231202582. doi: 10.1177/09612033231202582. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) patients report worse health-related quality of life (HRQL), fatigue, anxiety, depression, and sleep quality, when compared to the general population and other chronic diseases. Furthermore, cardiometabolic diseases are highly prevalent in SLE and are also associated with these parameters. Thus, it is plausible to suggest that SLE patients with a high cardiovascular risk may report worse results for these parameters. The aim of the study is to describe HRQL, fatigue, anxiety and depression s...
Source: Lupus - September 12, 2023 Category: Rheumatology Authors: Bruna Caruso Mazzolani Fabiana Infante Smaira Sofia Mendes Sieczkowska Marina Romero Thain á Toledo Ribeiro Milla Cordeiro Amarante Sandra Pasoto Ana L úcia de Sá Pinto Fernanda Rodrigues Lima Fabiana Braga Benatti Elo ísa Bonfa Hamilton Roschel Bruno Source Type: research
Prevalence of metabolic syndrome and components in rural, semi-urban and urban areas in the littoral region in Cameroon: impact of physical activity
CONCLUSIONS: MetS was more prevalent in urban dwellers and was associated with a low level of PA.PMID:37697395 | PMC:PMC10496244 | DOI:10.1186/s41043-023-00415-0
Source: Journal of Health, Population, and Nutrition - September 12, 2023 Category: International Medicine & Public Health Authors: Nadine Carole Bilog Jerson Mekoulou Ndongo Elys ée Claude Bika Lele Wiliam Richard Guessogo Peguy Brice Assomo-Ndemba None Ahmadou Noel Babayana Etaga Yves Julien Mbama Biloa Josiane Gertrude Bwegne Ngasse Bindi Abdou Temfemo Samuel Honor é Mandengue Je Source Type: research
Global, regional, and national burden of hypertensive heart disease among older adults in 204 countries and territories between 1990 and 2019: a trend analysis
CONCLUSIONS: In the past three decades, there has been an overall increasing trend in the prevalence of HHD among older adults worldwide despite decreasing trends in mortality and the DALY rate. Better management of hypertension, and prevention and control of HHD are needed in older adults.PMID:37698022 | DOI:10.1097/CM9.0000000000002863
Source: Chinese Medical Journal - September 12, 2023 Category: General Medicine Authors: Ruixue Yang Xun Zhang Jingjing Bai Lu Wang Wenjie Wang Jun Cai Source Type: research
Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
CONCLUSIONS: SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.PMID:37698017 | DOI:10.1161/CIRCRESAHA.123.322740
Source: Cell Research - September 12, 2023 Category: Cytology Authors: A Dushani C U Ranasinghe Maggie Holohan Kalyn M Borger Deborah L Donahue Rafael D Kuc Martin Gerig Andrew Kim Victoria A Ploplis Francis J Castellino Margaret A Schwarz Source Type: research
MicroRNAs and their regulators: Potential therapeutic targets in pulmonary arterial hypertension
Vascul Pharmacol. 2023 Sep 10:107216. doi: 10.1016/j.vph.2023.107216. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by pulmonary arterial remodeling. Despite that current combination therapy has shown improvement in morbidity and mortality, a better deciphering of the underlying pathological mechanisms and novel therapeutic targets is urgently needed to combat PAH. MicroRNA, the critical element in post-transcription mechanisms, mediates cellular functions mainly by tuning downstream target gene expression. Meanwhile, upstream regulators can regulate ...
Source: Vascular Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yang-Zhi-Ge He Yi-Xuan Wang Jing-Si Ma Ruo-Nan Li Jia Wang Tian-Yu Lian Yu-Ping Zhou Hao-Pu Yang Kai Sun Zhi-Cheng Jing Source Type: research
