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Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Beh çet's disease and autoinflammation. A viewpoint
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1578.ABSTRACTAdenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene. The DADA2 phenotype is widely heterogeneous, and patients may present with fever, weight loss, livedo reticularis/racemosa, digital ischemia, cutaneous ulceration, peripheral neuropathy, abdominal pain, bowel perforation, and portal or nephrogenic hypertension. More specific manifestations include early-onset ischemic or hemorrhagic stroke...
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: A Colangelo F Tromby G Cafaro R Gerli E Bartoloni C Perricone Source Type: research
Ethnicity and risk factors among Indian coronary artery disease patients
In this study, an attempt was made to investigate the distribution of coronary risk factors in male patients with coronary artery disease (CAD)(n=50 each) belonging to Jaat and Vaishya castes. A Significantly higher average height, waist and hip circumferences, glucose, and waist-height ratio were observed in Jaats compared to the Vaishyas (p=0.000). Mean BMI, total cholesterol (total-C) and non-high density lipoprotein cholesterol (HDL-C), and lean body mass index (LBMI) were significantly higher in Vaishyas against Jaats (p=0.00). A significantly higher percentage of type 2 diabetes(T2DM) (p=0.03) and isolated hypertrigl...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Monika Sah Latheef Saa Venkataramana P Source Type: research
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
This study examined the role of the nuclear hormone receptors, the estrogen-related receptors (ERRs), in regulation of age-related mitochondrial dysfunction and inflammation. The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR). A pan-ERR agonist, SLU-PP-332, was used to treat 21-month-old mice for 8-weeks. In addition, 21-month-old mice were treated with a STING inhibitor, C-176, for 3 weeks. Remarkably, similar to CR, only an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondri...
Source: Am J Pathol - September 17, 2023 Category: Pathology Authors: Xiaoxin X Wang Komuraiah Myakala Andrew E Libby Ewa Krawczyk Julia Panov Bryce A Jones Kanchan Bhasin Nataliia Shults Yue Qi Kristopher W Krausz Patricia M Zerfas Shogo Takahashi Parnaz Daneshpajouhnejad Avi Titievsky Elizaveta Taranenko Cyrielle Billon A Source Type: research
Pheochromocytoma and paraganglioma in children and adolescents
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6955. Online ahead of print.ABSTRACTPheochromocytoma (PPC) and paraganglioma (PGL) are the tumors that rarely occur in the pediatric population (PPGL). Both originate from chromaffin cells, pheochromocytoma is localized in the adrenal gland, whereas paragangliomas are regarded as the tumors present in other localizations, from head to the pelvis. The clinical image is characterized by the presence of the sustained hypertension, headaches, sweating, palpitations. The symptoms are caused by the catecholamine secretion or are related to tumor mass pressure on different org...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Teresa Stachowicz-Stencel Natalia Pasikowska Anna Synakiewicz Source Type: research
Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
This study examined the role of the nuclear hormone receptors, the estrogen-related receptors (ERRs), in regulation of age-related mitochondrial dysfunction and inflammation. The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR). A pan-ERR agonist, SLU-PP-332, was used to treat 21-month-old mice for 8-weeks. In addition, 21-month-old mice were treated with a STING inhibitor, C-176, for 3 weeks. Remarkably, similar to CR, only an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondri...
Source: The American Journal of Pathology - September 17, 2023 Category: Pathology Authors: Xiaoxin X Wang Komuraiah Myakala Andrew E Libby Ewa Krawczyk Julia Panov Bryce A Jones Kanchan Bhasin Nataliia Shults Yue Qi Kristopher W Krausz Patricia M Zerfas Shogo Takahashi Parnaz Daneshpajouhnejad Avi Titievsky Elizaveta Taranenko Cyrielle Billon A Source Type: research
Pheochromocytoma and paraganglioma in children and adolescents
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6955. Online ahead of print.ABSTRACTPheochromocytoma (PPC) and paraganglioma (PGL) are the tumors that rarely occur in the pediatric population (PPGL). Both originate from chromaffin cells, pheochromocytoma is localized in the adrenal gland, whereas paragangliomas are regarded as the tumors present in other localizations, from head to the pelvis. The clinical image is characterized by the presence of the sustained hypertension, headaches, sweating, palpitations. The symptoms are caused by the catecholamine secretion or are related to tumor mass pressure on different org...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Teresa Stachowicz-Stencel Natalia Pasikowska Anna Synakiewicz Source Type: research
Polyphyllin VII alleviates pulmonary hypertension by inducing miR-205-5p to target the β-catenin pathway
CONCLUSION: PP7 likely modulates β-catenin protein levels by promoting miR-205-5p expression, thereby alleviating PH, vascular remodeling and airway smooth muscle remodeling.PMID:37717533 | DOI:10.1016/j.biopha.2023.115516
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Fangyun Zhao Chunhong Pan Yue Zhang Jiao Yang Xiqian Xing Source Type: research
Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
This study examined the role of the nuclear hormone receptors, the estrogen-related receptors (ERRs), in regulation of age-related mitochondrial dysfunction and inflammation. The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR). A pan-ERR agonist, SLU-PP-332, was used to treat 21-month-old mice for 8-weeks. In addition, 21-month-old mice were treated with a STING inhibitor, C-176, for 3 weeks. Remarkably, similar to CR, only an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondri...
Source: The American Journal of Pathology - September 17, 2023 Category: Pathology Authors: Xiaoxin X Wang Komuraiah Myakala Andrew E Libby Ewa Krawczyk Julia Panov Bryce A Jones Kanchan Bhasin Nataliia Shults Yue Qi Kristopher W Krausz Patricia M Zerfas Shogo Takahashi Parnaz Daneshpajouhnejad Avi Titievsky Elizaveta Taranenko Cyrielle Billon A Source Type: research
Development and testing of a metabolic chamber for effluent collection during whole eye perfusions
Exp Eye Res. 2023 Sep 15:109652. doi: 10.1016/j.exer.2023.109652. Online ahead of print.ABSTRACTOcular hypertension is caused by dysregulated outflow resistance regulation by the conventional outflow (CO) pathway. The physiology of the CO pathway can be directly studied during ex vivo ocular perfusions. In addition to measuring outflow resistance generation by the CO tissues, perfusion media that is conditioned by CO pathway cells can be collected upon exiting the eye as effluent. Thus, contents of effluent include factors contributed by upstream cells that report on the (dys)functionality of the outflow tissues. Two metho...
Source: Experimental Eye Research - September 17, 2023 Category: Opthalmology Authors: Michael L De Ieso Ruth Kelly Philip Mzyk W Daniel Stamer Source Type: research
Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
This study examined the role of the nuclear hormone receptors, the estrogen-related receptors (ERRs), in regulation of age-related mitochondrial dysfunction and inflammation. The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR). A pan-ERR agonist, SLU-PP-332, was used to treat 21-month-old mice for 8-weeks. In addition, 21-month-old mice were treated with a STING inhibitor, C-176, for 3 weeks. Remarkably, similar to CR, only an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondri...
Source: Am J Pathol - September 17, 2023 Category: Pathology Authors: Xiaoxin X Wang Komuraiah Myakala Andrew E Libby Ewa Krawczyk Julia Panov Bryce A Jones Kanchan Bhasin Nataliia Shults Yue Qi Kristopher W Krausz Patricia M Zerfas Shogo Takahashi Parnaz Daneshpajouhnejad Avi Titievsky Elizaveta Taranenko Cyrielle Billon A Source Type: research
Polyphyllin VII alleviates pulmonary hypertension by inducing miR-205-5p to target the β-catenin pathway
CONCLUSION: PP7 likely modulates β-catenin protein levels by promoting miR-205-5p expression, thereby alleviating PH, vascular remodeling and airway smooth muscle remodeling.PMID:37717533 | DOI:10.1016/j.biopha.2023.115516
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Fangyun Zhao Chunhong Pan Yue Zhang Jiao Yang Xiqian Xing Source Type: research
Clipping of a Rebleeding Ruptured Aneurysm After Woven EndoBridge Treatment
CONCLUSION: As a conclusion, re-bleeding can be seen after aneurysm treatment with the Web device. If it is planned to re-close the aneurysm treated with the web device with a surgical clip, the pressure created by the device against the vessel can be reduced with the additional clip.PMID:37715605 | DOI:10.5137/1019-5149.JTN.41381-22.2
Source: Turkish Neurosurgery - September 16, 2023 Category: Neurosurgery Authors: Mustafa Caglar Sahin Fatih Oncu Burak Karaaslan Source Type: research
