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Total 1980994 results found since Jan 2013.

Increased vitamin B12 levels in patients with oral cancer
Conclusion: Our study found increased vitamin B12 levels in OC patients, and it was statistically significant.
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Prashant Gupta Subhash Chandra Awanindra Kumar Jha Tanya Khaitan Anjani Kumar Shukla Shantala R Naik Source Type: research

Imaging findings of granular cell tumours of the head and neck
To review the imaging characteristics of granular cell tumours in the head and neck and assess their associations with pathological findings.
Source: Clinical Radiology - September 22, 2023 Category: Radiology Authors: H.H. Moon, K. Jin, Y.J. Choi, K.-J. Cho, Y.S. Lee, J.H. Lee Source Type: research

Human pelvis injury risk curves from underbody blast impact
Conclusions This is the first study to develop axial and resultant force-based HIPCs defining human tolerance to injuries to the pelvis from vertical impacts using parametric survival analysis. Data can be used to advance military safety under vertical loading to the seated pelvis.
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Yoganandan, N., Moore, J., Humm, J. R., Baisden, J. L., Banerjee, A., Pintar, F. A., Barnes, D. R., Loftis, K. L. Tags: Original research Source Type: research

In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06159-3In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Lingfeng Yu Gentao Fan Qingyan Wang Yan Zhu Hao Zhu Jiang Chang Zhen Wang Shoubin Zhan Xianming Hua Diankun She Jianhao Huang Yicun Wang Jianning Zhao Chen-Yu Zhang Xi Chen Guangxin Zhou Source Type: research

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06155-7Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Liyuan Zhang Yue Dong Luxin Zhang Minjun Wang Ye Zhou Kaiwei Jia Suyuan Wang Mu Wang Yunhui Li Shudan Luo Shan Lu Yiwen Fan Dingji Zhang Yingyun Yang Nan Li Yizhi Yu Xuetao Cao Jin Hou Source Type: research

Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06149-5Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Yi Liu Hejing Liu Miaomiao Ye Mengying Jiang Xin Chen Gendi Song Huihui Ji Zhi-wei Wang Xueqiong Zhu Source Type: research

Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer ’s disease-associated pathology via anti-oxidative stress and autophagy activation
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Source: Journal of Asian Natural Products Research - September 22, 2023 Category: Complementary Medicine Authors: Natchadaporn SoraksaNudjanad HeebkaewWilasinee PromjantuekPhongsakorn KunhormPalakorn KaokeanNipha ChaicharoenaudomungParinya NoisaLaboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural Technology, Suranaree Un Source Type: research

A nomogram based on the preoperative neutrophil-to-lymphocyte ratio to distinguish sarcomatoid renal cell carcinoma from clear cell renal cell carcinoma
ConclusionNLR is a potential indicator for preoperative differentiation of SRCC and CCRCC, and the predictive model constructed based on NLR has a good predictive ability. The new model could provide suggestions for the early identification of SRCC.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma
ConclusionPostoperative serum SCC and CEA levels predict the overall survival of ESCC surgical patients. More importance should be attached to the use of these markers in clinical applications.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Survival benefit with checkpoint inhibitors versus chemotherapy is modified by brain metastases in patients with recurrent small cell lung cancer
ConclusionCPI was associated with a lower risk of 1-year mortality compared to chemotherapy. However, the effect on OS was significantly modified by intracranial disease and radiotherapy, suggesting the benefit was driven by patients without BM.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Genomic view of the origins of cell-mediated immunity
AbstractNKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ) –type immunoglobulin superfamily (IgSF) domain. Such VJ-IgSF domains predate the emergence of the antigen receptors (immunoglobulin and T cell receptor), which possess the same domain but undergo gene rearrangement.NCR3, the gene encoding NKp30, is present in jawed vertebrates from sharks to mammals; thus, unlike most NKR that are highly divergent among vertebrate taxa, NKp30 is uniquely conserved. We previously hypothesized that an ancestralNCR3 gene was encoded in the proto-major histocompatibility complex (MHC), the reg...
Source: Immunogenetics - September 22, 2023 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 15, Pages 4681: Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model
Kwang Seok Ahn DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and its downstream signals. DA induced apoptotic cell death and inhibited the expression of diverse tumorigenic pr...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Min Hee Yang Mina Lee Amudha Deivasigamani Duc Dat Le Chakrabhavi Dhananjaya Mohan Kam Man Hui Gautam Sethi Kwang Seok Ahn Tags: Article Source Type: research

Cancers, Vol. 15, Pages 4679: Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases
Suzanne D. Conzen Estrogen receptor-positive (ER+) invasive lobular breast cancer (ILC) comprises about ~15% of breast cancer. ILC’s unique genotypic (loss of wild type E-cadherin expression) and phenotypic (small individual round cancer cells that grow in discontinuous nests) are thought to contribute to a distinctive pattern of metastases to serosal membranes. Unlike invasive ductal carcinoma (IDC), ILC metastases often intercalate into the mesothelial layer of the peritoneum and other serosal surfaces. While ER activity is a known driver of ILC proliferation, very little is known about how additiona...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Baylee A. Porter Candace Frerich Muriel Lain é Abigail B. Clark Ishrat Durdana Jeon Lee Manisha Taya Sunati Sahoo Geoffrey L. Greene Lynda Bennett Suzanne D. Conzen Tags: Article Source Type: research

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq
DiscussionWith this work, we showed that despite having only a few differentially expressed genes, diverse analysis methods could be applied to retrieve relevant information on phthalates, showing the potential of in vitro thyroid-relevant systems for the analysis of endocrine disruptors.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research

The Effects of Human Papillomavirus Status and Treatment on the Positive Predictive Value of Post-radiotherapy 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Advanced Head and Neck Squamous Cell Carcinoma
The high negative predictive value of post-chemoradiation (CRT) positron emission tomography-computed tomography (PET-CT) is well established in head and neck squamous cell cancers (HNSCC). The positive predictive value (PPV) remains under scrutiny, with increasing evidence that it is affected by several factors. The aim of this study was to assess the PPV of post-treatment PET-CT for residual nodal disease when stratified by treatment modality and tumour human papillomavirus (HPV) status.
Source: Clinical Oncology - September 22, 2023 Category: Radiology Authors: S. Zhou, C. Chan, Y.C. Lau, R. Rulach, H. Dyab, F. Hendry, C. Wilson, S. Schipani, C. Lamb, D. Grose, A. James, C. Maxfield, M.-F. Dempsey, C. Paterson Tags: Original Article Source Type: research