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Total 1980994 results found since Jan 2013.
GSE241452 Effect of methanol fixation on single cell RNA sequencing of the murine dentate gyrus (droplet-based scRNAseq).
Contributors : Marta S ánchez-Carbonell ; Patricia Jiménez Peinado ; Cathrin Bayer-Kaufmann ; Jean-Christopher Hennings ; Yvonne Hofmann ; Silvio Schmidt ; Otto W Witte ; Anja UrbachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe evaluated the effect of methanol (MeOH) fixation on adult murine dentate gyrus (DG) single cell suspensions processed with droplet-based scRNA-seq.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE241368 Pax7 ablation model enables evaluation of stem cell niche formation in the absence of mouse Pax7 cell competition
Contributors : Michael Hicks ; April PyleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSequencing files, and processed data correspond to Figure 3 of Regenerating Human Skeletal Muscle Forms an Emerging Niche In Vivo to Support PAX7 cells. Data contains single nucleus RNA seq from Pax7 ablated mdx-NSG mice, control mdx-NSG mice, with or without an injury. These mice offer superior engraftment by human skeletal muscle stem and progenitor cells. Pax7 ablation model enables evaluation of human stem cell niche formation in the absence of mouse Pax7 cell competition. Included in this dat...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE240793 human induced pluripotent stem cell-derived cardiomyocytes
Series Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Expression profiling by array Homo sapiens Source Type: research
GSE240792 Changes in gene profiles during the long term culture of human induced pluripotent stem cell-derived cardiomyocytes
Contributors : Shugo Tohyama ; Otoya SekineSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the changes in gene profiles during the long-term culture process of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, we conducted microarray analysis on hiPSC(253G4 line)- derived cardiomyocytes at three time points: 20 days, 35 days, and 50 days after the initiation of differentiation induction.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE240790 The profile of miRNAs secreted into the supernatant during cardiac differentiation and maturation from human induced pluripotent stem cells verified by miRNA array analysis.
Contributors : Shugo Tohyama ; Otoya SekineSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe performed miRNA array analysis to analyze the miRNAs secreted into the supernatant during the mesoderm/cardiac differentiation and maturation process from human induced pluripotent stem cells (hiPSCs). Supernatant samples were collected on day -1, day 3, day 5, day 7, day 9, day 21, day 35, and day 51.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
GSE240232 Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
Contributor : Jincheng HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial anti-tumor activity followed by recurrence due to cancer cell intrinsic and immune mediated paracrine mechanisms. Here, we explored the potential role of cancer associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2/ERBB3 receptor tyrosine kinases as a mechanism by which KRAS* independent...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE234802 Amino acid intake strategies define pluripotent cell states
Contributors : Pavlina K Todorova ; Katrina I Paras ; Lydia W FinleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmino acid intake strategies define pluripotent cell states
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE232052 Effect of methanol fixation on single cell RNA sequencing of the murine dentate gyrus.
Contributors : Marta S ánchez-Carbonell ; Patricia Jiménez Peinado ; Cathrin Bayer-Kaufmann ; Jean-Christopher Hennings ; Yvonne Hofmann ; Silvio Schmidt ; Otto W Witte ; Anja UrbachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe evaluated the effect of methanol (MeOH) fixation on adult murine dentate gyrus (DG) single cell suspensions.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE228062 Prostate tissue explant, epithelial cell, stromal cell, and extracellular vesicle microRNA characterization by NGS
Contributors : Larisa Nonn ; Morgan Zenner ; Trevor LeonardoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIntracellular and extracellular vesicle-contained microRNAs were profiled by next-generation sequencing from prostate cancer patient cells, tissues and serum.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE228044 Differential usage of DNA modifications in neurons, astrocytes and microglia WGoxBS
Contributors : Kyla B Tooley ; Ana J Chucair-Elliott ; Sarah R Ocanas ; Kevin D Pham ; David R Stanford ; Willard M FreemanSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusCellular identity is determined, in part, by cell type-specific epigenomic profiles that govern gene expression. Isolation and epigenomic characterization of specific cell types is greatly needed in neuroscience. While single cell DNA modification studies offer promise to answer this question, these approaches suffer from limited genomic coverage and cannot differentiate between methylation and hydroxymethylation. T...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
GSE228043 Differential usage of DNA modifications in neurons, astrocytes and microglia RNA-seq
Contributors : Kyla B Tooley ; Ana J Chucair-Elliott ; Sarah R Ocanas ; Kevin D Pham ; David R Stanford ; Willard M FreemanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular identity is determined, in part, by cell type-specific epigenomic profiles that govern gene expression. Isolation and epigenomic characterization of specific cell types is greatly needed in neuroscience. While single cell DNA modification studies offer promise to answer this question, these approaches suffer from limited genomic coverage and cannot differentiate between methylation and hydroxymethylation. Th...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE218383 Nanostring gene expression data, comparison of response to subcutaneously implanted porcine-derived decellularized myocardial matrix hydrogels in mast cell deficient mice compared to deficient mice with mast cell engraftment and wild-type C57BL6/J mice
Contributors : Raymond M Wang ; Karen L ChristmanSeries Type : Expression profiling by arrayOrganism : Mus musculusNanostring gene expression count data from the Nanostring Mouse Immunology Panel consisting of 546 genes with 15 internal controls from excised subcutaneous injections of porcine derived decellularized myocardial matrix hydrogels that were lysed and extracted for total RNA. Data was then exported through the manufacturer nSolverTM Analysis Software 4.0 and analyzed through custom R scripts under R versions 4.04 with normalized counts determined by the NanostringDiff package and thresholding outside of one stan...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE214003 Single cell sequecing analysis of exhausted CD8 T cell subsets in LCMV-clone13 infected mice
Contributors : Martin Vaeth ; Wolfgang Kastenm üller ; Konrad KnöpperSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify the subsets of exhausted T cells and to analyze the transcriptional-metabolic programs alongside their developmental trajectories at single-cell resolution, we isolated CD44+ PD-1hi CD8+ T cells from chronically infected wild-type (WT) mice 21 days after infection with the ‘clone 13’ strain of lymphocytic choriomeningitis virus (LCMV) by FACs sorting aand performed scRNA-sequencing.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE213981 Endogenous B cell TACI-Short-APRIL signaling
Contributors : Miguel Fribourg ; Yolanda CarmonaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we show that TACI-S increases its expression with maturation and colocalizes in the intracellular compartment with the ligand APRIL. APRIL downregulation in human B cells, eliminated class switch. These studies suggest the importance of intracellular APRIL together with TACI-S in maintaining humoral immunity.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE213847 Single-cell sequecing of LCMV-specific WT and HIF-1a-deficient CD8 T cells isolated from LCMV-Clone13 infected host mice
Contributors : Martin Vaeth ; Hao WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine the role of hypoxia-inducible factor 1 alpha (HIF-1a) in exhausted T cells, we crossed Hif1a-fl/fl Cd4-Cre mice to tdTomato+ P14 animals and adoptively co-transferred equal numbers of WT and HIF-1a-deficient P14 CD8+ T cells into chronically infected WT host mice. 21 days post infection, we retrieved GFP+ (WT) and tdTomato+ (HIF-1a-deficient) donor P14 T cells by FACS sorting and subjected CITE-seq antibody-barcoded WT and HIF-1a-deficient CD8+ P14 T cells to multiplexed scRNA sequencing analysis.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
