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Total 1980994 results found since Jan 2013.
Role of telitacicept in the treatment of IgA nephropathy
This article reviews the role of telitacicept in IgA nephropathy and discusses its potential for use in the treatment of IgAN and other autoimmune diseases where pathogenesis is driven by B cells.PMID:37737205 | DOI:10.1186/s40001-023-01320-2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Lijun Wu Xinru Du Xuehong Lu Source Type: research
Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis
CONCLUSION: Circ_0000396 restrained the proliferation and inflammation and induced the apoptosis of RASFs by mediating miR-574-5p/RSPO1 axis, which provided novel potential targets for RA treatment.PMID:37737195 | DOI:10.1186/s13018-023-04117-5
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Hongchao Yu Jin Yang Kun Chen Wulin Kang Fengfeng Zhu Source Type: research
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
Construction of an anoikis ‒related prognostic signature to predict immunotherapeutic response and prognosis in hepatocellular carcinoma
CONCLUSION: A successful anoikis-related prognostic signature and corresponding clinical nomogram were established, which might facilitate better predictions of prognosis and therapeutic responses for HCC patients.PMID:37736789 | DOI:10.1007/s00432-023-05428-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Chen Xiong Guoqiang Pan Hanchao Wang Guangxiao Meng Lunjie Yan Ruizhe Li Yuchuan Yan Yafei Yang Xiao Zhang Chuncheng Yang Zhaoru Dong Tao Li Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
In this study, we identified positive as well as negative regulators of Moesin. Our study reveals that Moesin is a cellular target of F-box protein FBXW2. We showed that FBXW2 suppresses breast cancer progression through directing proteasomal degradation of Moesin. In contrast, AKT kinase plays an important role in oncogenic function of Moesin by protecting it from FBXW2-mediated proteasomal degradation. Mechanistically, AKT phosphorylates Moesin at Thr-558 and thereby prevents its degradation by FBXW2 via weakening the association between FBXW2 and Moesin. Further, accumulated Moesin prevents FBXW2-mediated degradation of...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ganesh Kumar Barik Osheen Sahay Anindya Mukhopadhyay Rajesh Kumar Manne Sehbanul Islam Anup Roy Somsubhra Nath Manas Kumar Santra Source Type: research
Therapeutic benefits of prophetic medicine remedies in treating hematological diseases (A review article)
Am J Blood Res. 2023 Aug 15;13(4):130-142. eCollection 2023.ABSTRACTHematological disorders are common medical ailments constituting an important cause of morbidity and mortality worldwide, which may be managed efficiently using different prophetic medicine remedies as adjuvants to current therapeutics. Prophetic medicine includes the body of knowledge about medicine that has been derived from the deeds, customs (sunnah), ahadith (sayings), actions, and agreements of Prophet Muhammad, peace be upon him. This review article aims at exploring the magnitude of therapeutic benefits of prophetic medicine remedies as adjuvant tr...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ghazi H Mogharbel Ahmad S Badawi Amal Yaseen Zaman Mehrevan M Abd Elmoniem Ibrahim M Abdel-Rahman Mariam Eid Alenazi Fareed Akbar Shah Mohamed Abdelnaem Aly Syed Nazar Imam Nusaybah Eid Alenazi Salah Mohamed El Sayed Source Type: research
Personalized Immunotherapy of Patients: Defining by Single-cell RNA-seq with Artificial Intelligence
Med Res Arch. 2023 Aug;11(8):10.18103/mra.v11i8.4293. doi: 10.18103/mra.v11i8.4293. Epub 2023 Aug 30.ABSTRACTImmunotherapy, including immune cell therapy and targeted therapy, is gradually developed through the ongoing discovery of molecular compounds or immune cells. Choosing the best one or the best combination of target compounds and immune-cell therapy is a challenge for clinical scientists and clinicians. We have found variable efficacy individually after tumor-infiltrating lymphocyte (TIL) therapy, and now TILs have been discovered in a group of heterogeneous immune cells. To select the best immunotherapy for each pa...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Biaoru Li Source Type: research
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Conclusions: High resolution chromatin interaction profiles at selectively targeted loci can complement genome- and promoter-wide maps.PMID:37736013 | PMC:PMC10509606 | DOI:10.12688/wellcomeopenres.18653.2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jason M Torres Han Sun Vibe Nylander Damien J Downes Martijn van de Bunt Mark I McCarthy Jim R Hughes Anna L Gloyn Source Type: research
Cordycepin, a bioactive compound from < em > Cordyceps spp < /em > ., moderates Alzheimer's disease-associated pathology via anti-oxidative stress and autophagy activation
This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. Cordycepin was found to boost SH-SY5Y cell proliferation and decreased AD pathology. APP, PS1, and PS2 were downregulated whereas ADAM10 and SIRT1 were upregulated by cordycepin. Cordycepin also reduced APP secretion in a dose-dependent manner. Cordycepin alleviated oxidative stress by the upregulation of GPX and SOD, as well as autophagy genes (LC3, ATG5, and ATG12). Cordycepin activity was also found to be SIRT1-dependent. Therefore, cordycepin may relieve the neuronal ...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Natchadaporn Soraksa Nudjanad Heebkaew Wilasinee Promjantuek Phongsakorn Kunhorm Palakorn Kaokean Nipha Chaicharoenaudomung Parinya Noisa Source Type: research
Force-Loaded Cementocytes Regulate Osteoclastogenesis via S1P/S1PR1/Rac1 Axis
J Dent Res. 2023 Sep 21:220345231195765. doi: 10.1177/00220345231195765. Online ahead of print.ABSTRACTOrthodontically induced inflammatory root resorption (OIIRR) is the major iatrogenic complication of orthodontic treatment, seriously endangering tooth longevity and impairing masticatory function. Osteoclasts are thought to be the primary effector cells that initiate the pathological process of OIIRR; however, the cellular and molecular mechanisms responsible for OIIRR remain unclear. Our previous studies revealed that cementocytes, the major mechanically responsive cells in cementum, respond to compressive stress to act...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: H Wang T Li Y Jiang S Chen S Zou L F Bonewald P Duan Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers
CONCLUSION: Our results suggested that CYFIP2 may serve as a prognostic cancer biomarker for determining prognosis and might be a promising therapeutic strategy for tumor immunotherapy.PMID:37735711 | DOI:10.1186/s40001-023-01366-2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Qiliang Peng Bixin Ren Kedao Xin Weihui Liu Md Shahin Alam Yinyin Yang Xuhao Gu Yaqun Zhu Ye Tian Source Type: research
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
J Orthop Surg Res. 2023 Sep 22;18(1):713. doi: 10.1186/s13018-023-04119-3.ABSTRACTOsteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytok...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Source Type: research
Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research
