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Total 1980994 results found since Jan 2013.
Conformal 3D computed tomography planned endoluminal brachytherapy for the local control of esophageal cancer
To outline the toxicity, tolerability, and efficacy of a 3D conformal computed tomography planned endoluminal brachytherapy (ELBT) treatment for esophageal adenocarcinoma (OAC) or squamous cell carcinoma (OSCC).
Source: Brachytherapy - September 22, 2023 Category: Cancer & Oncology Authors: Christopher M. Jones, Annabel Lyles, Peter Bownes, Rebecca Goody, Mohan Hingorani, Eldho Joseph, Ganesh Radhakrishna Source Type: research
MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: a prospective, observational study
Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown.
Source: Diabetes Research and Clinical Practice - September 22, 2023 Category: Endocrinology Authors: Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini Source Type: research
Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research
Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacte...
Source: Cell Communication and Signaling - September 22, 2023 Category: Molecular Biology Authors: Hongjiao Li, Yi Wang, Shuang Feng, Kaijing Chang, Xinwen Yu, Fenfang Yang, Haozhe Huang, Yuanbo Wang, Xiang Li and Feng Guan Tags: Research Source Type: research
A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
ConclusionsTargeting CD74 with 74bbz CAR-T cells represents a new cell therapy to provide a potent and durable and anti-MCL activity.
Source: Experimental Hematology and Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Spinal Cord Compression from Widespread Extramedullary Hematopoiesis in Polycythemia Vera
Extramedullary hematopoiesis describes the proliferation of blood cells outside the bone marrow in the presence of predisposing hematological disorders, such as thalassemia, sickle cell anemia, polycythemia vera, and myelofibrosis. It usually occurs in sites related to hematopoiesis during fetal development and has rarely been reported in other locations. Since the first published report in 1958 by Close et al. 1, there have been a few reports of spinal cord compression due to extramedullary hematopoiesis in the spinal epidural space.
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Adelaide Valluzzi, Julian S. Rechberger, Francesca Palandri, Davide Nasi, Giacomo Pavesi, Giorgio Palandri Tags: Clinical Communication to the Editor Source Type: research
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers —Do We Have Enough Evidence?
AbstractThis current opinion article critically evaluates the efficacy of autologous cell therapy (ACT) for chronic limb-threatening ischemia (CLTI), especially in people with diabetes who are not candidates for standard revascularization. This treatment approach has been used in ‘no-option’ CLTI in the last two decades and more than 1700 patients have received ACT worldwide. Here we analyze the level of published evidence of ACT as well as our experience with this treatment method. Many studies have shown that ACT is safe and an effective method for patients with the mo st severe lower limb ischemia. However, some tri...
Source: Molecular Diagnosis and Therapy - September 22, 2023 Category: Molecular Biology Source Type: research
Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review
AbstractVitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent skin depigmentation. Although many theories have been proposed in the literature, none alone explains the pathogenesis of vitiligo. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo. A growing body of evidence suggests that antioxidant therapies may offer a promising approach to managing this condition. This review summarises the potential mechanisms of oxidative stress and the types of melanocyte death in vitiligo. We also provide a brief overview of the most commonly studied antioxi...
Source: Molecular Diagnosis and Therapy - September 22, 2023 Category: Molecular Biology Source Type: research
A novel near-infrared EGFR targeting probe for metastatic lymph node imaging in preclinical mouse models
For the treatment of patients with oral squamous cell carcinoma (OSCC), the imaging of cervical lymph nodes and the evaluation of metastastic progression are of great significance. In recent years, the develop...
Source: Journal of Nanobiotechnology - September 22, 2023 Category: Nanotechnology Authors: Diya Xie, Yunlong Li, Jiahong Shi, Yao Ping Zhu, Yiqing Wang, Christopher J. Butch and Zhiyong Wang Tags: Research Source Type: research
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but subcutaneous fat (SC) stromal cells...
Source: Journal of Nanobiotechnology - September 22, 2023 Category: Nanotechnology Authors: Shu Zhao, Guanghui Xiu, Jian Wang, Yi Wen, Jinyuan Lu, Baitong Wu, Guangming Wang, Danjing Yang, Bin Ling, Dajiang Du and Jun Xu Tags: Research Source Type: research
BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains
ConclusionsOur results demonstrate significant BBBo levels induced by extra-cranial L-PEFs, enabling efficient delivery of therapeutic Doxo doses into the brain and reducing tumor growth. As BBBo was undetectable by standard contrast-enhanced MRI, DCM was applied to generate maps depicting the BBBo levels throughout the brain. These findings suggest that BDF is a promising technology for efficient drug delivery into the brain with important implications for future treatment of brain cancer and additional CNS diseases.
Source: Fluids and Barriers of the CNS - September 22, 2023 Category: Neuroscience Source Type: research
A multicenter randomized, controlled clinical trial of adjuvant sintilimab for esophageal squamous cell carcinoma
Future Oncology, Ahead of Print.
Source: Future Oncology - September 22, 2023 Category: Cancer & Oncology Authors: Hai-Bo Sun Wen-Qun Xing Xian-Ben Liu Shu-Jun Yang Pei-Nan Chen Shi-Lei Liu Peng Li Ya-Xing Ma Duo Jiang Sen Yan Source Type: research
Circadian entrainment to red-light Zeitgebers and action spectrum for entrainment in the jewel wasp Nasonia vitripennis
In this study, we investigated the possibility ofNasonia circadian light entrainment under long-wavelength red LED light –dark cycles and characterized the strength of red light as a potentialZeitgeber. Additionally, we measured the possibility of entrainment under various light intensities (from 5 ·1012 to 4 ·1015 photons ·cm−2·s−1) and a broader range of wavelengths (455 —656 nm) to construct corresponding action spectra for characterizing all circadian photoreceptors involved in photic entrainment. We also conducted electroretinogram (ERG) recordings for each wavelength in the compound eyes. Our findings dem...
Source: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology - September 22, 2023 Category: Physiology Source Type: research
The 3' end of the coding region of senecavirus A contains a highly conserved sequence that potentially forms a stem-loop structure required for virus rescue
AbstractSenecavirus A (SVA) can cause a vesicular disease in swine. It is a positive-strand RNA virus belonging to the genusSenecavirus in the familyPicornaviridae. Positive-strand RNA viruses possess positive-sense, single-stranded genomes whose untranslated regions (UTRs) have been reported to containcis-acting RNA elements. In the present study, a total of 100 SVA isolates were comparatively analyzed at the genome level. A highly conserved fragment (HCF) was found to be located in the 3D sequence and to be close to the 3' UTR. The HCF was computationally predicted to form a stem-loop structure. Eight synonymous mutation...
Source: Archives of Virology - September 22, 2023 Category: Virology Source Type: research
TRIP13 overexpression in hepatocellular carcinoma: implications for poor prognosis and immune cell infiltration
ConclusionThese findings suggest that TRIP13 could be a potential prognostic biomarker for HCC.
Source: Hormones and Cancer - September 22, 2023 Category: Cancer & Oncology Source Type: research
