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Pentec Health and Lobe Sciences Announce Exclusive Distribution Agreement, Initial Availability of Altemia, First U.S. Medical Food for People With Sickle Cell Disease
Pentec Health, Inc. (Pentec) and Lobe Sciences Ltd. (CSE: LOBE) (OTCQB: LOBEF) ("Lobe" or the "Company") are pleased to announce an exclusive U.S. distribution agreement and the initial availability of Altemia™ – the first medical food in the U.S. designed specifically for children and...
Source: PRWeb: Medical Pharmaceuticals - September 21, 2023 Category: Pharmaceuticals Tags: LIC Source Type: news
Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Synaptic Dysfunction Precedes the Death of Neurons in Parkinson ' s Disease
Parkinson's disease is characterized by the loss of dopamine-generating neurons, with the inflammatory pathology leading up to that issue thought to be driven by the spread of misfolded α-synuclein. Dysfunctional mitochondrial quality control can make these dopamine-generating neurons more vulnerable to the underlying pathology, however, and thus a fraction of Parkinson's disease arises in people with mutations that cause this sort of dysfunction. That has directed researchers towards mitochondrial function as an important factor in the progression of the condition, but it will probably turn out to be more useful to focus...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Ann Biomed Eng. 2023 Sep 20. doi: 10.1007/s10439-023-03370-3. Online ahead of print.ABSTRACTTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine. In this review, we first summarize different harvesting procedures and advantages of cell sheet techn...
Source: Annals of Biomedical Engineering - September 21, 2023 Category: Biomedical Engineering Authors: Yexin Li Ting Deng Dilihumaer Aili Yang Chen Weihong Zhu Qian Liu Source Type: research
Flow cytometric characterization of cell surface markers to differentiate between fibroblasts and mesenchymal stem cells of different origin
CONCLUSIONS: The results of our study indicate that cell surface markers may prove to be a useful tool in the discrimination between MSCs of different origins and fibroblasts, and thus may be used to authenticate the identity of the isolated cells.PMID:37732070 | PMC:PMC10507789 | DOI:10.5114/aoms/131088
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Suzanne A Sober Homa Darmani Dana Alhattab Abdalla Awidi Source Type: research
Extremely elevated serum procalcitonin concentration in a patient with stage IV non-small cell lung cancer
Arch Med Sci. 2023 Aug 25;19(5):1581-1583. doi: 10.5114/aoms/170963. eCollection 2023.NO ABSTRACTPMID:37732057 | PMC:PMC10507777 | DOI:10.5114/aoms/170963
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Rafa ł Stando Grzegorz Chmielewski Source Type: research
The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research
< em > Equisetum arvense < /em > L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma
CONCLUSIONS: The cell viability of Equisetum arvense L was very low against human colorectal carcinoma cell lines without any cytotoxicity towards the normal (HUVEC) cell line. The best anti-human colorectal carcinoma properties of Equisetum arvense L against the above cell lines were observed in the case of the HT 29 cell line.PMID:37732051 | PMC:PMC10507773 | DOI:10.5114/aoms/138146
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Lei Wang Luojun Zhang Guangtao Zheng Haiping Luo Attalla F El-Kott Ayman E El-Kenawy Source Type: research
Cardiac microRNAs: diagnostic and therapeutic potential
Arch Med Sci. 2023 Aug 25;19(5):1360-1381. doi: 10.5114/aoms/169775. eCollection 2023.ABSTRACTMicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. In cardiovascular disease pathophysiology, there are several cells that produce microRNAs, including endothelial cells, vascular smooth muscle cells, macrophages, platelets, and cardiomyocytes. There is a constant crosstalk between microRNAs derived from variou...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Anna Kab łak-Ziembicka Rafa ł Badacz Micha ł Okarski Magdalena Wawak Tadeusz Przew łocki Jakub Podolec Source Type: research
Variation in the gene encoding the co-inhibitory molecule BTLA is associated with survival in patients treated for clear cell renal carcinoma - results of a prospective cohort study
CONCLUSIONS: Our results indicate for the first time that genetic variation within the gene encoding BTLA is significantly associated with overall survival in clear cell renal cell carcinoma patients.PMID:37732048 | PMC:PMC10507760 | DOI:10.5114/aoms/142407
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Krzysztof Tupikowski Anna Partyka Edyta A Pawlak Kuba Ptaszkowski Romuald Zdrojowy Irena Frydecka Agnieszka Ha łoń Lidia Karabon Source Type: research
The role of tensins in malignant neoplasms
Arch Med Sci. 2021 Jan 26;19(5):1382-1397. doi: 10.5114/aoms/127085. eCollection 2023.ABSTRACTTensins belong to the family of adhesion proteins which form focal adhesions serving as a bridge between the extracellular matrix and intracellular actin skeleton. The tensin family consists of four members (tensin-1 to -4) which are widely expressed in normal and cancerous tissues. The presence of Src homology 2 and phosphotyrosine binding domains is a unique feature of tensins which enables them to interact with tyrosine-phosphorylated proteins in PI3K/Akt and β-integrin/FAK signaling pathways. The tensin-mediated signaling pat...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Marcin Nizio ł Anna Pryczynicz Source Type: research
Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell lines
CONCLUSIONS: Berberine exhibited cytotoxic effects on multiple cancer cell lines by inducing apoptosis and cell cycle arrest. The BCL-2/BAX signaling pathway may be the common pathway underlying the anti-tumor effect of berberine. The findings support the notion that berberine is a dietary compound that can be further developed into a drug candidate for cancer treatment.PMID:37732040 | PMC:PMC10507748 | DOI:10.5114/aoms/132969
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qian Li Hui Zhao Weimin Chen Ping Huang Source Type: research
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in Poland: analysis of patient series and practical guidelines for breast surgeons
CONCLUSIONS: BIA-ALCL is scarce in the Polish population. In a short-term follow-up, patients' prognosis remains excellent. Due to the withdrawal of roughly textured implants from the market and the exclusion of likely the most potent etiologic factor, it might be expected that the incidence of BIA-ALCL will become even rarer.PMID:37732037 | PMC:PMC10507758 | DOI:10.5114/aoms.2020.100637
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Piotr Pluta Agnieszka Giza Ma łgorzata Kolenda Wojciech Fendler Marcin Braun Cezary Chudobi ński Justyna Cha łubińska-Fendler Micha ł Araszkiewicz Karolina Loga Lubomir Lembas Magdalena Witkowska Agnieszka Pluta Jerzy Kolasi ński Pawe ł Basta Agnie Source Type: research
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research
Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia
This report summarizes the workshop and highlights selected presentations.PMID:37731161 | DOI:10.1007/s12192-023-01383-4
Source: Cell Stress and Chaperones - September 21, 2023 Category: Cytology Authors: Christian M ünch Janine Kirstein Source Type: research
