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Cancers, Vol. 15, Pages 4686: The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review
ldaiturriaga Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Although recent multi-omic studies have led to advances in MB classification, there is still room for improvement with regard to treatment response and survival. Therefore, identification of new and less invasive biomarkers is needed to refine the diagnostic process and to develop more personalized treatment strategies. In this context, non-coding RNAs (ncRNAs) could be useful biomarkers for MB. In this article, we reviewed the role of two types of ncRNAs, long non-coding (lncRNAs) and circular RNAs (circRNAs), as biomarkers for th...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ivan Martinez de Estibariz Anastasija Jakjimovska Unai Illarregi Idoia Martin-Guerrero Angela Guti érrez-Camino Elixabet Lopez-Lopez Nerea Bilbao-Aldaiturriaga Tags: Systematic Review Source Type: research

Cancers, Vol. 15, Pages 4685: Role of DNA Methylation Profiles as Potential Biomarkers and Novel Therapeutic Targets in Head and Neck Cancer
t Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is associated with high mortality. The main reasons for treatment failure are a low rate of early diagnosis, high relapse rates, and distant metastasis with poor outcomes. These are largely due to a lack of diagnostic, prognostic, and predictive biomarkers in HNSCC. DNA methylation has been demonstrated to play an important role in the pathogenesis of HNSCC, and recent studies have also valued DNA methylation as a potential biomarker in HNSCC. This review summarizes the current knowledge on DNA methylation profiles in HPV-posi...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Kyunghee Burkitt Tags: Review Source Type: research

Cancers, Vol. 15, Pages 4684: Prognostic Factors in Advanced Non-Small Cell Lung Cancer Patients Treated with Immunotherapy
re Gridelli Taking into account the huge epidemiologic impact of lung cancer (in 2020, lung cancer accounted for 2,206,771 of the cases and for 1,796,144 of the cancer-related deaths, representing the second most common cancer in female patients, the most common cancer in male patients, and the second most common cancer in male and female patients) and the current lack of recommendations in terms of prognostic factors for patients selection and management, this article aims to provide an overview of the current landscape in terms of currently available immunotherapy treatments and the most promising assessed prognostic...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Danilo Rocco Luigi Della Gravara Angela Ragone Luigi Sapio Silvio Naviglio Cesare Gridelli Tags: Review Source Type: research

A phase I study of the ceramide nanoliposome in patients with advanced solid tumors
ConclusionsCNL exhibited an encouraging safety profile and pharmacokinetic parameters, with some signals of efficacy including prolonged stable disease in 1 patient with  refractory pancreatic cancer. Pre-clinical data indicate potential synergy between CNL and multiple systemic therapies including chemotherapy, targeted therapy, and immunotherapy. Future studies are planned investigating CNL in combination strategies.Trial registrationThis study is registered under ClinicalTrials.gov ID: NCT02834611.
Source: Cancer Chemotherapy and Pharmacology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Non-chemical signalling between mitochondria
A wide variety of studies have reported some form of non-chemical or non-aqueous communication between physically isolated organisms, eliciting changes in cellular proliferation, morphology, and/or metabolism. The sources and mechanisms of such signalling pathways are still unknown, but have been postulated to involve vibration, volatile transmission, or light through the phenomenon of ultraweak photon emission. Here, we report non-chemical communication between isolated mitochondria from MCF7 (cancer) and MCF10A (non-cancer) cell lines. We found that mitochondria in one cuvette stressed by an electron transport chain inhi...
Source: Frontiers in Physiology - September 22, 2023 Category: Physiology Source Type: research

Estimating Remaining Life Expectancy in Veterans with Basal Cell Carcinoma Using an Automated Electronic Health Record Scoring System: A Retrospective Cohort Study
Active surveillance may be considered for low-risk basal cell carcinomas (BCC) in patients with limited life expectancy; however, estimates of life expectancy are not readily available. Veterans Health Administration ’s (VHA) Care Assessment Need (CAN) score may address this problem.
Source: Journal of the American Academy of Dermatology - September 22, 2023 Category: Dermatology Authors: Matthew P. Dizon, Eleni Linos, Susan M. Swetter Source Type: research

Sclerotic-type chronic graft-versus-host disease exhibits activation of Th1 and OX40 cytokines
In this study, we compared the transcriptome in skin biopsies from pediatric and young adult (
Source: Journal of Investigative Dermatology - September 22, 2023 Category: Dermatology Authors: Madeline Kim, Yael Renert-Yuval, Polina Stepensky, Ehud Even-Or, Irina Zaidman, Tahel Fachler, Michal Neumark, Mariana Zamir, Monali NandyMazumdar, Digpal Gour, Paola Facheris, Britta Carroll, Ying Liu, Mitchelle L. Yu Ekey, Elizabeth Andrews, Marguerite Tags: Original Article Source Type: research

Molecules, Vol. 28, Pages 6768: Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage
This study shows a way of developing a proteome-based meter for measuring irreversible shockwave-induced cell damage and provides a resource for identifying protein biomarkers of TBIs and potential drug targets for the development of products aimed at primary prevention and intervention.
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Amir Ata Saei Hassan Gharibi Hezheng Lyu Brady Nilsson Maryam Jafari Hans Von Von Holst Roman A. Zubarev Tags: Article Source Type: research

“Buprenorphine, It Works so Differently”: Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain
A growing body of literature describes the use of buprenorphine for the treatment of chronic pain in people with sickle cell disease. The experiences of people with sickle cell disease who have tried buprenorphine are not yet reported. This qualitative descriptive study was conducted to explore perspectives on buprenorphine for chronic pain in sickle cell disease. We interviewed 13 participants with sickle cell disease who had been prescribed buprenorphine and had a clinic visit between December 1, 2020 and April, 2022 in our Sickle Cell Center for Adults.
Source: The Journal of Pain - September 22, 2023 Category: Materials Science Authors: Elizabeth Prince, Paul Loeser, Macy Early, C. Patrick Carroll, Sophie Lanzkron, Lydia H. Pecker Source Type: research

Characterisation of common genetic variants in P2RX7 and their contribution to chronic pain conditions
In this study, we first systematically characterized all 17 common nonsynonymous variants using whole-cell patch clamp electrophysiology. Then, we analyzed these variants for statistical association with chronic pain phenotypes using both individual P2RX7 variants as predictors and cumulative allele counts of same-direction cellular effect in univariate models.
Source: The Journal of Pain - September 22, 2023 Category: Materials Science Authors: Katerina Zorina-Lichtenwalter, Ariel R. Ase, Vivek Verma, Arturo I.M. Parra, Svetlana Komarova, Anmar Khadra, Philippe S éguéla, Luda Diatchenko Tags: Original Reports Source Type: research

Molecules, Vol. 28, Pages 6769: Revealing the Control Mechanisms of pH on the Solution Properties of Chitin via Single-Molecule Studies
Zheng Lu Qian Chitin is one of the most common polysaccharides and is abundant in the cell walls of fungi and the shells of insects and aquatic organisms as a skeleton. The mechanism of how chitin responds to pH is essential to the precise control of brewing and the design of smart chitin materials. However, this molecular mechanism remains a mystery. Results from single-molecule studies, including single-molecule force spectroscopy (SMFS), AFM imaging, and molecular dynamic (MD) simulations, have shown that the mechanical and conformational behaviors of chitin molecules show surprising pH responsiveness. This can be...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Song Zhang Miao Yu Guoqiang Zhang Guanmei He Yunxu Ji Juan Dong Huayan Zheng Lu Qian Tags: Article Source Type: research

Mesenchymal Stem Cells as an Adjuvant Tool to Induce Regeneration and Repair in Marginal Renal Allografts
AbstractPurpose of ReviewMesenchymal stem cells (MSC) have been largely studied for more than three decades and have been proposed to treat a myriad of clinical conditions in dozens of clinical trials.Recent FindingsThey have become popular in transplant medicine due to their immunomodulatory properties with promising results. In the past decade, however, they have also been tested in the setting of organ preservation in reason of their ability to induce regeneration and repair in damaged tissues.SummaryThis manuscript reviews the worldwide experience relative to the use of MSC and their by-products, as therapeutic tool to...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise?
AbstractPurpose of ReviewThis manuscript aims at contextualizing the termregenerative surgery, whose recent introduction in the medical jargon has generated some confusion on both its significance and interplay with its synonymousregenerative medicine.Recent FindingsThe manuscript will illustrate the worldwide experience relative to the development ofregenerative surgery–related technologies, as they may be applied and be of interest to transplant medicine. Only few centers have invested in these technologies, the most relevant of which is cell on scaffold seeding technologies whereby cells, ideally isolated from the pat...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Urticaria in childhood —what’s new?
AbstractUrticaria can manifest at any age, including infants and young children. Urticaria is one of the most prevalent skin diseases in childhood. As in adults, a  distinction is made between acute and chronic urticaria, with chronic urticaria further classified into chronic spontaneous urticaria and inducible urticaria. According to the current German S3 guideline for classification, diagnosis, and treatment of urticaria, existing literature suggests that the prevalence, disease characteristics, causes, and also the response to treatment are very similar in children and adults. The clinical hallmark of urticaria is the...
Source: Allergo Journal International - September 22, 2023 Category: Allergy & Immunology Source Type: research

Genes, Vol. 14, Pages 1838: Whole-Exome Sequencing of 24 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Keratoconus
Irene Rosa-Pérez Juan Carlos Acal Joana Blasco Marta Naranjo-Castresana Beatriz Ruz-Caracuel Victoria E. F. Montaño Cristina Ortega Patrón M. Esther Rubio-Martín Laura García-Fernández Emi Rikeros-Orozco María de Los Ángeles Gómez-Cano Luna Delgado-Mora Susana Noval Elena Vallespín Keratoconus is a corneal dystrophy that is one of the main causes of corneal transplantation and for which there is currently no effective treatment for all patients. The presentation of this disease in pediatric age is associated with rapid progression, a worse prognosis and, in 15–20% of ...
Source: Genes - September 22, 2023 Category: Genetics & Stem Cells Authors: Carmen Gonz ález-Atienza Elo ísa Sánchez-Cazorla Natalia Villoldo-Fern ández Almudena del Hierro Ana Boto Marta Guerrero-Carretero Mar ía Nieves-Moreno Natalia Arruti Patricia Rodr íguez-Solana Roc ío Mena Carmen Rodr íguez-Jiménez Irene Rosa-P Tags: Article Source Type: research