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Total 1980994 results found since Jan 2013.
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF- κB pathways
This study demonstrates that NBP maintains BBB function by activating the Nrf2/HO-1 pathway and inhibiting the NOD2/MAPK/NF-κB pathway to suppress inflammation and oxidative stress, thereby alleviating renal I/R-induced brain injury.PMID:37732403 | DOI:10.1080/0886022X.2023.2259234
Source: Renal Failure - September 21, 2023 Category: Urology & Nephrology Authors: Jingjing Min Qi Chen Mengxiong Pan Tan Liu Qun Gu Dongwei Zhang Ru Sun Source Type: research
CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CONCLUSIONS: A threshold effect is shown to exist between the peripheral blood CD4 and distant metastasis in NSCLC patients. It was revealed that the risk of distant metastasis is lower when CD4 is maintained between 32 and 44%, whereas low (< 32%) or high (> 44) levels of CD4 are associated with an increased risk of distant metastasis in NSCLC patients.PMID:37733240 | DOI:10.1007/s00432-023-05418-2
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Ying Bai Yafeng Liu Jing Wu Rui Miao Zhi Xu Chunxiao Hu Jiawei Zhou Jianqiang Guo Jun Xie Zilun Shi Xuansheng Ding Yingru Xing Dong Hu Source Type: research
Immunomodulatory activity of dipeptidyl peptidase-4 inhibitors in immune-related diseases
This article is protected by copyright. All rights reserved.PMID:37732495 | DOI:10.1002/eji.202250302
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Marija Drakul Miodrag Čolić Source Type: research
STARGATE-X: a Python package for statistical analysis on the REACTOME network
J Integr Bioinform. 2023 Sep 21. doi: 10.1515/jib-2022-0029. Online ahead of print.ABSTRACTMany important aspects of biological knowledge at the molecular level can be represented by pathways. Through their analysis, we gain mechanistic insights and interpret lists of interesting genes from experiments (usually omics and functional genomic experiments). As a result, pathways play a central role in the development of bioinformatics methods and tools for computing predictions from known molecular-level mechanisms. Qualitative as well as quantitative knowledge about pathways can be effectively represented through biochemical ...
Source: Journal of integrative bioinformatics - September 21, 2023 Category: Bioinformatics Authors: Andrea Marino Blerina Sinaimeri Enrico Tronci Tiziana Calamoneri Source Type: research
Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous carcinoma cells (HSC-3)
CONCLUSION: Overall, our findings shed an experimental evidence on how calotropin inhibits the HSC-3 oral squamous cancer cell growth, highlighting the drug's potential as a treatment for oral cancer. Further, investigation on in-vivo experiment is warranted to explore its potential mechanism of action and to develop a novel drug towards clinical trial.PMID:37731845 | PMC:PMC10507650 | DOI:10.1016/j.jobcr.2023.09.002
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Selvaraj Jayaraman Sathan Raj Natarajan Vishnu Priya Veeraraghavan Sharmila Jasmine Source Type: research
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma Retraction
Cancer Manag Res. 2023 Sep 15;15:1011-1012. doi: 10.2147/CMAR.S440061. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.2147/CMAR.S261894.].PMID:37731840 | PMC:PMC10508229 | DOI:10.2147/CMAR.S440061
Source: Cell Research - September 21, 2023 Category: Cytology Source Type: research
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
RSC Med Chem. 2023 Jun 26;14(9):1603-1628. doi: 10.1039/d3md00151b. eCollection 2023 Sep 19.ABSTRACTFungal infections cause severe and life-threatening complications especially in immunocompromised individuals. Antifungals targeting cellular machinery and cell membranes including azoles are used in clinical practice to manage topical to systemic fungal infections. However, continuous exposure to clinically used antifungal agents in managing the fungal infections results in the development of multi-drug resistance via adapting different kinds of intrinsic and extrinsic mechanisms. The unique chemical composition of fungal m...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Devashish Mehta Varsha Saini Avinash Bajaj Source Type: research
Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment
CONCLUSIONS: Subtype of SCLC generally remains the same after acquiring chemotherapy resistance. Plasticity was observed with rare cases switching from NEUROD1-predominant to ASC1-predominant SCLC. Resubtyping is unnecessary for the consideration of novel subtype-specific targeted agents, except cases with NEUROD1-predominant subtype.PMID:37731627 | PMC:PMC10507151 | DOI:10.1016/j.jtocrr.2023.100561
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Ying-Chun Lo Joel Rivera-Concepcion George Vasmatzis Marie-Christine Aubry Konstantinos Leventakos Source Type: research
Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial Reservoirs
J Dent Res. 2023 Sep 20:220345231191115. doi: 10.1177/00220345231191115. Online ahead of print.ABSTRACTThe human mouth, or oral cavity, is at the crossroads of our external and internal environments, and it is increasingly evident that local colonization of dental, oral, and craniofacial (DOC) tissues and cells by bacteria and viruses may also have systemic effects across myriad diseases and disorders. Better understanding of this phenomenon will require a holistic understanding of host-microbial interactions in both spatiotemporal and biogeographical contexts while also considering person-, organ-, tissue-, cell-, and mol...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Q T Easter B Fernandes Matuck B M Warner K M Byrd Source Type: research
The protective effect of apigenin against inorganic arsenic salt-induced toxicity in PC12 cells
In conclusion, the obtained results of the present study have clinical significance and indicate that apigenin is a promising candidate for shielding the nervous system from toxic effects caused by arsenic. These findings require further investigation using in vivo experimental models.PMID:37730986 | DOI:10.1007/s11356-023-29884-w
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Rafa Almeer Nouf M Alyami Source Type: research
Learning human liver biology in humanized mice
Cell Res. 2023 Sep 20. doi: 10.1038/s41422-023-00877-1. Online ahead of print.NO ABSTRACTPMID:37730939 | DOI:10.1038/s41422-023-00877-1
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Brandon M Lehrich Satdarshan P Monga Source Type: research
LICOB: a powerful organoid platform for drug discovery
Cell Res. 2023 Sep 20. doi: 10.1038/s41422-023-00878-0. Online ahead of print.NO ABSTRACTPMID:37730938 | DOI:10.1038/s41422-023-00878-0
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Haojie Jin Zhen Sun Ren é Bernards Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Breast Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Alpinetin: anti-human gastric cancer potential and urease inhibition activity < em > in vitro < /em >
CONCLUSIONS: It seems that the anti-human gastric carcinoma effect of the investigated molecule is due to its antioxidant effects.PMID:37732032 | PMC:PMC10507754 | DOI:10.5114/aoms/138832
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Hui Zhang Qian Jiang Guojin Gong Mingzhen Li Saad H Alotaibi Source Type: research
Novel green synthesis of silver nanoparticles mediated by < em > Curcumae kwangsiensis < /em > for anti-lung cancer activities: a preclinical trial study
CONCLUSIONS: After confirming the above results in the clinical trial research, this formulation can be administered to treat human lung cancers in humans.PMID:37732031 | PMC:PMC10507782 | DOI:10.5114/aoms/134059
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Zhihong Liu Zhuohong Zhang Xiaomei Du Ying Liu Abdullah Alarfaj Abdurahman Hirad Siddique Akber Ansari Zhiguo Zhang Source Type: research
