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Total 1980994 results found since Jan 2013.

Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation
CONCLUSION: It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish population; thus, follow-up and treatment protocols are organized following the European and American databases and guidelines. A comprehensive study of the colorectal carcinoma patients' mutation profile in the Turkish patient cohort by the next-generation sequencing method will help to provide significant therapeutic, prognostic, and predictive data and design more successfu...
Source: The Turkish Journal of Gastroenterology - September 22, 2023 Category: Gastroenterology Authors: Sibel Osman Nesibe Kahraman Çetin İbrahim Halil Erdoğdu İbrahim Meteoğlu Source Type: research

Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4  + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Herpes - September 22, 2023 Category: Infectious Diseases Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research

Giant cell lichenoid dermatitis within healed varicella zoster site
Clin Case Rep. 2023 Sep 19;11(9):e7585. doi: 10.1002/ccr3.7585. eCollection 2023 Sep.ABSTRACTThere are dermatoses that arise within healed zosteriform sites, such as granulomas annulare, acneiform eruptions, psoriasis, lichen planus, and giant cell lichenoid dermatitis "GCLD." Nonetheless, graft-versus-host disease should be considered and ruled out, especially in patients post-bone marrow transplant. Herein, we report a case of GCLD manifesting within healed zosteriform sites.PMID:37736473 | PMC:PMC10509341 | DOI:10.1002/ccr3.7585
Source: Herpes - September 22, 2023 Category: Infectious Diseases Authors: Yara Alghamdi Bashaer Almahdi Sahar Alsifri Hassan Huwait Abdulhadi Jfri Source Type: research

Vandetanib alters the tumoricidal capacity of human breast cancer stem cells via inhibiting vasculogenic capacity
CONCLUSION: Vandetanib suppressed vasculogenic mimicry (VM) networking through blunting stemness properties, coincided with suppression of VE-cadherin in CSCs.PMID:37736340 | PMC:PMC10509738 | DOI:10.34172/bi.2022.24208
Source: BioImpacts - September 22, 2023 Category: Research Authors: Sanya Haiaty Mohammad-Reza Rashidi Maryam Akbarzadeh Ahad Bazmany Mostafa Mostafazadeh Saba Nikanfar Roya Shabkhizan Rostam Rezaeian Reza Rahbarghazi Mohammad Nouri Source Type: research

Autophagy-induced mesenchymal stem cell-derived extracellular vesicles ameliorated renal fibrosis in an < em > in vitro < /em > model
CONCLUSION: Our findings suggest that AEVs can be considered as a therapeutic modality for renal fibrosis in the future.PMID:37736337 | PMC:PMC10509741 | DOI:10.34172/bi.2022.24256
Source: BioImpacts - September 22, 2023 Category: Research Authors: Behnaz Ahrabi Hojjat Allah Abbaszadeh Abbas Piryaei Faezeh Shekari Navid Ahmady Roozbahany Mahya Rouhollahi Forough Azam Sayahpour Mahnaz Ahrabi Hadi Azimi Reza Moghadasali Source Type: research

Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8 < sup > + < /sup > T lymphocytes against < em > Leishmania major < /em >
CONCLUSION: α-AL2O3 nanoparticles enhance the cross-presentation of L. major antigens to CD8+ T cells by inducing autophagy. This finding supports the positive role of autophagy and encourages the use of α-AL2O3 in vaccine design.PMID:37736336 | PMC:PMC10509742 | DOI:10.34172/bi.2023.25282
Source: BioImpacts - September 22, 2023 Category: Research Authors: Fatemeh Beyzay Ahmad Zavaran Hosseini Ali Hazrati Mozhdeh Karimi Sara Soudi Source Type: research

NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia
In conclusion, high expression of NKG2A dominates NK cell phenotypes from pediatric BCP-ALL patients, indicating that NKG2A could be targeted in therapies for this patient group.PMID:37738462 | DOI:10.1093/jleuko/qiad112
Source: Journal of Leukocyte Biology - September 22, 2023 Category: Hematology Authors: Aina Ulvmoen Victor Greiff Anne G Bechensteen Marit Inngjerdingen Source Type: research

Activation of PI3K/Akt pathway by G protein ‐coupled receptor 37 promotes resistance to cisplatin‐induced apoptosis in non‐small cell lung cancer
ConclusionsIt was suggested that GPR37 acts a crucial role in promoting the occurrence and development of NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC. Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC.
Source: Cancer Medicine - September 22, 2023 Category: Cancer & Oncology Authors: Han Liu, Yingjie Zhu, Huikun Niu, Jing Jie, Shucheng Hua, Xiaoxue Bai, Shuai Wang, Lei Song Tags: RESEARCH ARTICLE Source Type: research

Directional Cell Migration Guided by a Strain Gradient
This work reports directional single cell migration guided by a strain gradient, termed tensotaxis. A programmable uniaxial cell stretch device is developed to establish a continuous strain gradient field without generating a stiffness gradient. Focal adhesion analysis and motor-clutch model demonstrate that tensotaxis is driven by strain-introduced traction force and integrin fibronectin pairs' catch-release dynamics. AbstractStrain gradients widely exist in development and physiological activities. The directional movement of cells is essential for proper cell localization, and directional cell migration in responses to ...
Source: Small - September 22, 2023 Category: Nanotechnology Authors: Feiyu Yang, Pengcheng Chen, Han Jiang, Tianfa Xie, Yue Shao, Deok ‐Ho Kim, Bo Li, Yubing Sun Tags: Research Article Source Type: research

One ‐step production of fully biotinylated and glycosylated human Fc gamma receptors
AbstractInitiating and regulating humoral immunity, Fc gamma receptors (Fc γRs) have been identified both as therapeutics and as drug targets, and thus production of biologically active FcγRs is highly demanded for biopharmaceutical development. Focusing on low-affinity FcγRs IIA (131H/R allotypes), IIB, and IIIA (176F/V), this study used human 293-F cells to achieve co rrect post-translational modifications (PTMs) including biotinylation,N-glycosylation, and disulfides. Approaches involving co-expression of Fc γR-AviTag andEscherichia coli biotin ligase BirA, endoplasmic reticulum retention, stable and transient trans...
Source: Biotechnology Progress - September 22, 2023 Category: Biotechnology Authors: Minhyo Kang, Zening Wang, Xin Ge Tags: RESEARCH ARTICLE Source Type: research

Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A. Haas, Andreas Vlachos, Christian Schachtrup, Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research

Multi ‐perspectives and challenges in identifying B ‐cell epitopes
This article is protected by copyright. All rights reserved.
Source: Protein Science - September 22, 2023 Category: Biochemistry Authors: Nishant Kumar, Nisha Bajiya, Sumeet Patiyal, Gajendra P. S. Raghava Tags: REVIEW ARTICLE Source Type: research

Girl receives UK ’s first kidney transplant without need for lifelong drugs
Aditi Shankar, eight, has pioneering treatment resulting in her body accepting donor kidney as its ownAn eight-year-old girl has been spared from taking lifelong drugs to stop her body rejecting her kidney transplant thanks to a UK-first treatment.Aditi Shankar ’s immune system was “reprogrammed” after a stem cell transplant, resulting in her body accepting a donor kidney as its own, clinicians said.Continue reading...
Source: Guardian Unlimited Science - September 22, 2023 Category: Science Authors: PA Media Tags: NHS Health UK news Society Source Type: news

Use of ropeginterferon in inducing graft versus myelofibrosis effect in post ‐transplant myelofibrosis relapse
JAK2 level and chimerism after ropeginterferon treatment for relapsed myelofibrosis after allogeneic stem cell transplantation. Key Clinical MessageHere, we describe a patient with post-transplant myelofibrosis with chronic graft-versus-host disease (GVHD), who showed successful molecular remission with ropeginterferon with 100% donor chimerism without any flare up of GVHD. He was initially diagnosed with polycythemia vera (PV) which progressed to myelofibrosis after 6  years. The MYSEC (Myelofibrosis Secondary to PV and ET-Prognostic Model) and MTSS (myelofibrosis transplant scoring system) scores were 13.1 and 4, respe...
Source: Clinical Case Reports - September 22, 2023 Category: General Medicine Authors: Barnali Srivastava, Christine Wolschke, Nico Gagelmann, Anita Badbaran, Nicolaus Kr öger Tags: CASE REPORT Source Type: research

GSE243793 High-resolution dissection of human cell-type specific enhancers in cis and trans activities
This study provides a new perspective of sequence intrinsic enhancer activities in different types of cells.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research