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Total 1980994 results found since Jan 2013.
Single-Cell RNA Sequencing Reveals Cellular Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress
CONCLUSIONS: We showed that flow shear stress modulates the cellular capacity of ECs to respond to paclitaxel and rapamycin administration, suggesting that while responding to different flow patterns, ECs experience an impairment in their transcriptional adaptation to other stimuli.PMID:37732484 | DOI:10.1161/ATVBAHA.123.319283
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Antonio G Salazar-Mart ín Aditya S Kalluri Martin A Villanueva Travis K Hughes Marc H Wadsworth Ii Tyler T Dao Mercedes Balcells Farhad R Nezami Alex K Shalek Elazer R Edelman Source Type: research
Aging Is Associated With Organ-Specific Alterations in the Level and Expression Pattern of von Willebrand Factor
CONCLUSIONS: Aging elicits a heterogenic response in endothelial cells with regard to VWF expression, leading to organ-specific increase in VWF levels and alterations in vascular tree pattern of expression. This is concomitant with increased platelet aggregate formation. The age-associated increase in VWF expression may be modulated through the process of cell senescence, and p53 transcription factor contributes to its regulation.PMID:37732483 | DOI:10.1161/ATVBAHA.123.319255
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Parnian Alavi Radya Yousef Abdualla Douglas Brown Anahita Mojiri Jayan Nagendran John Lewis Stephane L Bourque Nadia Jahroudi Source Type: research
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Effectiveness and safety of Shenqi Fuzheng injection combined with platinum-based chemotherapy for treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSION: SFI combined with PBC for the treatment of advanced NSCLC improved the ORR, DCR, and quality of life, and reduced the incidence of myelosuppression and gastrointestinal adverse reactions. However, considering the limitations of existing evidence, further verification using high-quality RCTs is required.SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/inplasy-2022-7-0026, identifier INPLASY202270026.PMID:37731634 | PMC:PMC10507621 | DOI:10.3389/fonc.2023.1198768
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Chenxi Qiao Shuaihang Hu Dandan Wang Kangdi Cao Zhuo Wang Xinyan Wang Xiumei Ma Zheng Li Wei Hou Source Type: research
Topical Calcipotriol Plus Imiquimod Immunotherapy for Nonkeratinocyte Skin Cancers
In this study, we demonstrate that topical TSLP cytokine inducers-calcipotriol and retinoic acid-synergize with IMQ to activate CD4+ T-cell immunity against nonkeratinocyte cutaneous malignancies. Topical calcipotriol plus IMQ treatment reduced breast tumor growth compared with calcipotriol or IMQ alone (P < 0.0001). Calcipotriol plus IMQ-mediated tumor suppression was associated with significant infiltration of CD4+ effector T cells in the tumor microenvironment. Notably, topical calcipotriol plus IMQ immunotherapy enabled immune checkpoint blockade therapy to effectively control immunologically cold breast tumors, whi...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Marjan Azin Kenneth H Ngo Jennet Hojanazarova Shadmehr Demehri Source Type: research
Down-regulation of interleukin-2 predicts poor prognosis and associated with immune escape in lung adenocarcinoma
Conclusion: Our results indicate that down-regulation of IL2 predicts poor prognosis and is associated with immune escape in LUAD, and IL2 could serve as a potential novel prognostic biomarker of LUAD.PMID:37731383 | DOI:10.1177/03946320231202748
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Yongwang Hou Baoli Xiang Zhicong Yang Jiangmin Liu Dandan Xu Lina Geng Minghua Zhan Yuhuan Xu Bin Zhang Source Type: research
Tetrahydrobiopterin from cyanide-degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)
Biotechnol Appl Biochem. 2023 Sep 20. doi: 10.1002/bab.2509. Online ahead of print.ABSTRACTTetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide-degrading Bacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24 h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4-treated A549 cells sho...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Ramasamy Mahendran Sanjay Prasad Selvaraj Anand Raj Dhanapal Sabna Bhaskaran Sarasa Beutline Malgija Mathias Bency Thankappan Daniel Raja Femil Selta Palanivel Naveen Rhenghachar Poorani Navaneethan Sundhar Mamatha M Pillai Rajendran Selvakumar Chih-Yang Source Type: research
A Comparison of the effect of patient-specific vs. weight-based protocols to treat vaso-occlusive episodes (VOE) in the emergency department
CONCLUSIONS: We found a shorter ED length of stay for patients assigned to a PSP. Patients in both groups experienced good pain relief without significant side effects.PMID:37731093 | DOI:10.1111/acem.14805
Source: Accident and Emergency Nursing - September 21, 2023 Category: Emergency Medicine Authors: Paula Tanabe Stephanie Ibemere Ava E Pierce Caroline E Freiermuth Hayden B Bosworth Hongqui Yang Ifeyinwa Osunkwo James H Paxton John J Strouse Joseph Miller Judith A Paice Padmaja Veeramreddy Patricia L Kavanagh R Gentry Wilkerson Robert Hughes Huiman X Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Med Oncol. 2023 Sep 20;40(10):303. doi: 10.1007/s12032-023-02169-5.ABSTRACTHead and neck cancers (HNC) continues to dominate major cancers contributing to mortality worldwide. Squamous cell carcinoma is the major type of HNC. Oral Squamous Cell Carcinoma grouped under HNC is a malignant tumor occurring in the oral cavity. The primary risk factors of OSCC are tobacco, alcohol consumption, etc. This review focuses on modulations, mechanisms, growth and differentiation of oral squamous cell carcinoma. Cancer cell surrounds itself with a group of elements forming a favorable environment known as tumor microenvironment (TME). I...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Suganya Ramalingam Sivaramakrishnan Shantha Susruthan Muralitharan Uma Sudhakar Harikrishnan Thamizhchelvan Venkatachalam Deepa Parvathi Source Type: research
Design and synthesis of novel 1,2,3,4-tetrazines as new anti-leukemia cancer agents
Chem Biol Drug Des. 2023 Sep 20. doi: 10.1111/cbdd.14328. Online ahead of print.ABSTRACTA series of novel 1,2,3,4-tetrazines were designed and synthesized. 1 H-NMR spectroscopy, 13 C NMR spectroscopy, and HRMS were used to determine the structures of this novel compounds. Computational approaches suggested that DHFR is a putative target for the newly synthesized 11 compounds. Extensive molecular dynamics simulations followed by molecular docking simulations were employed to evaluate DHFR as a potential target protein. The anticancer activities of the compounds were evaluated against five different types of leukemia cell li...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Oznur Eyilcim Fulya Gunay Omer Tahir Gunkara Yuk Yin Ng Ozlem Ulucan Ihsan Erden Source Type: research
Identification of stromal cell-derived factor 4 as a liquid biopsy-based diagnostic marker in solid cancers
In conclusion, serum SDF4 levels could be a promising candidate for a novel diagnostic biomarker for GC and other malignancies.PMID:37730904 | DOI:10.1038/s41598-023-42201-2
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Takahiro Shinozuka Mitsuro Kanda Dai Shimizu Shinichi Umeda Hideki Takami Yoshikuni Inokawa Norifumi Hattori Masamichi Hayashi Chie Tanaka Goro Nakayama Yasuhiro Kodera Source Type: research
Performance evaluation the new automated Atellica Hema 580 hematology analyzer
CONCLUSION: The Atellica Hema 580 showed good analytical performance and workflow efficiency for a wide range of patient samples.PMID:37731006 | DOI:10.1111/ijlh.14170
Source: International Journal of Laboratory Hematology - September 21, 2023 Category: Hematology Authors: E Schapkaitz A Baiden S Raburabu Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
