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Total 1980994 results found since Jan 2013.

Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway
The study aims to investigate the apoptotic effects of combining LBH589 and AM1241 (a selective CB2 receptor agonist) on cervical cancer cells and elucidating the mechanism of this combined therapy, which may ...
Source: BMC Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Authors: Bo Sheng, Wenwen Wang, Dongyue Xia and Xiangdong Qu Tags: Research Source Type: research

Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06134-yDepletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Zhiqin Fang Yutong Wang Bo Huang Xiang Chen Rundong Jiang Mingzhu Yin Source Type: research

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06144-wEmerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Jinghan Li Sujuan Zheng Yumei Fan Ke Tan Source Type: research

Role of telitacicept in the treatment of IgA nephropathy
This article reviews the role of telitacicept in IgA nephropathy and discusses its potential for use in the treatment of IgAN and other autoimmune diseases where pathogenesis is driven by B cells.
Source: European Journal of Medical Research - September 22, 2023 Category: Research Source Type: research

Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
Discussion Our study shows that circulating integrin β7+ memory CD4 T cells of patients with relapsing-remitting MS under natalizumab are enriched in proinflammatory cells supporting the hypothesis that integrin β7+ memory CD4 T cells could play a pathogenic role in the disease rebound observed at natalizumab discontinuation.
Source: Neurology Neuroimmunology and Neuroinflammation - September 22, 2023 Category: Neurology Authors: Nguyen Ky, M., Duran, A., Hasantari, I., Bru, A., Deloire, M., Brochet, B., Ruet, A., Schmitt, N. Tags: All Immunology, Multiple sclerosis Research Article Source Type: research

Dermatological toxicities induced by T-cell-redirecting GPRC5D bispecific antibody talquetamab
Source: Journal of the American Academy of Dermatology - September 22, 2023 Category: Dermatology Authors: M. Lery, A. Perrot, A. Ortiz-Brugu és, E. Vigarios, D. Anghel, P. Bories, V. Sibaud Source Type: research

Adipose-derived stem cells significantly increases collagen level and fiber maturity in patient-specific biological engineered blood vessels
by Bryan T. Wonski, Bijal Patel, Donna G. Tepper, Aamir Siddiqui, Loay S. Kabbani, Mai T. Lam Tissue engineering has driven significant research in the strive to create a supply of tissues for patient treatment. Cell integration into engineered tissues maximizes functional capabilities, however, issues of rejection remain. Autologous cell sources able to solve this issue are difficult to i dentify for tissue engineering purposes. Here, we present the efficacy of patient-sourced cells derived from adipose (adipose-derived stem cells, ASCs) and skin tissue (dermal fibroblasts, PtFibs) to build a combined engineered tunica m...
Source: PLoS One - September 22, 2023 Category: Biomedical Science Authors: Bryan T. Wonski Source Type: research

Abnormal outer hair cell efferent innervation in < i > Hoxb1 < /i > -dependent sensorineural hearing loss
In this study, we assessed whether the abnormal auditory threshold and malformation of the sensory auditory cells, the outer hair cells, described inHoxb1null mutants depend on the absence of efferent motor innervation, or alternatively, is due to altered sensory auditory components. By using a whole series of conditional mutant mice, which inactivateHoxb1 in either rhombomere 4-derived sensory cochlear neurons or efferent motor neurons, we found that the hearing phenotype is mainly reproduced when efferent motor neurons are specifically affected. Our data strongly suggest that the interactions between olivocochlear motor ...
Source: PLoS Genetics - September 22, 2023 Category: Genetics & Stem Cells Authors: Maria Di Bonito Source Type: research

Potential involvement of the bone marrow in experimental Graves ’ disease and thyroid eye disease
ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated ...
Source: Biology Direct - September 22, 2023 Category: Biology Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Rapha ëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers and Heidi M. McBride Tags: Research Source Type: research

Documentation of International Staging System (ISS) and Revised International Staging System (R-ISS) for Multiple Myeloma at a Tertiary Care Center: A Clinical Audit
In this study, we looked at the risk stratification done in our hospital setting among Newly diagnosed multiple myeloma patients (NDMM), and we noticed a time-based improvement in both ISS and R-ISS documentation, which reflects the evolution of better risk stratification of patients in clinical practice.
Source: Indian Journal of Clinical Biochemistry - September 22, 2023 Category: Biochemistry Source Type: research

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited with 37 genes, encoding 13 poly...
Source: Journal of Biomedical Science - September 22, 2023 Category: Biomedical Science Authors: Chao Chen and Min-Xin Guan Tags: Review Source Type: research

SARS-CoV-2 egress from Vero cells: a morphological approach
This study aimed to shed light on the morphological features of SARS-CoV-2 egress by utilizing transmission and high-resolution scanning electron microscopy, along with serial electron tomography, to describe the route of nascent virions towards the extracellular medium. Electron microscopy revealed that the clusters of viruses in the paracellular space did not seem to result from collective virus release. Instead, virus accumulation was observed on incurved areas of the cell surface, with egress primarily occurring through individual vesicles. Additionally, our findings showed that the emission of long membrane projection...
Source: Histochemistry and Cell Biology - September 22, 2023 Category: Biomedical Science Source Type: research

Transplant Outcomes of Myelofibrosis with Busulfan and Fludarabine Myeloablative Conditioning
Allogeneic stem cell transplantation (allo-SCT) remains the only curative treatment for patients with intermediate and high-risk myelofibrosis (MF). Notable improvements in survival of patients with MF after allo-SCT have been made over the past two decades, though relapse remains a frequent cause of treatment failure.1, 2 Several prognostic systems have been validated to predict survival in patients with MF,3, 4 including some that have recently incorporated several genetic and mutational markers into their systems.
Source: Biology of Blood and Marrow Transplantation - September 22, 2023 Category: Hematology Authors: Jacinth Joseph, Samer A. Srour, Den ái R. Milton, Jeremy L. Ramdial, Neeraj Y. Saini, Amanda L. Olson, Qaiser Bashir, Betul Oran, Amin M. Alousi, Chitra Hosing, Muzaffar H. Qazilbash, Partow Kebriaei, Elizabeth J. Shpall, Richard E. Champlin, Uday R. Pop Source Type: research

Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease
Haemoglobin SC (HbSC) is a common form of sickle cell disease (SCD), especially among individuals of West African ancestry. Persons with HbSC disease suffer from the same clinical complications and reduced qua...
Source: Trials - September 22, 2023 Category: General Medicine Authors: Luke R. Smart, Catherine I. Segbefia, Teresa S. Latham, Susan E. Stuber, Kwesi N. Amissah-Arthur, Klenam Dzefi-Tettey, Adam C. Lane, Yvonne A. Dei-Adomakoh and Russell E. Ware Tags: Study protocol Source Type: research