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Total 1980994 results found since Jan 2013.
CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CONCLUSIONS: A threshold effect is shown to exist between the peripheral blood CD4 and distant metastasis in NSCLC patients. It was revealed that the risk of distant metastasis is lower when CD4 is maintained between 32 and 44%, whereas low (< 32%) or high (> 44) levels of CD4 are associated with an increased risk of distant metastasis in NSCLC patients.PMID:37733240 | DOI:10.1007/s00432-023-05418-2
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Ying Bai Yafeng Liu Jing Wu Rui Miao Zhi Xu Chunxiao Hu Jiawei Zhou Jianqiang Guo Jun Xie Zilun Shi Xuansheng Ding Yingru Xing Dong Hu Source Type: research
M < sup > 6 < /sup > A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway
Discov Oncol. 2023 Sep 21;14(1):175. doi: 10.1007/s12672-023-00786-0.ABSTRACTHuman Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 ...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Miao Li Qianwen Guo Qian Shi Yanzhi Rao Yixin Dong Fangjie Chen Xun Qi Source Type: research
Is triggering receptor expressed on myeloid cell 1 (TREM-1) protein a new marker of serious infectious complications in colorectal surgery?: case-matched pilot study
CONCLUSION: TREM-1 measurements might become a helpful predictive marker in the early diagnosis of serious infectious complications in patients following laparoscopic colorectal surgery.PMID:37733081 | DOI:10.1007/s00423-023-03103-z
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Magdalena Pisarska-Adamczyk Anna Rzepa Maria Kapusta Karolina Zawadzka Beata Ku śnierz-Cabala Micha ł Wysocki Piotr Ma łczak Piotr Major Anna Zub-Pokrowiecka Mateusz Wierdak Micha ł Pędziwiatr Source Type: research
Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma
CONCLUSIONS: ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.PMID:37733060 | DOI:10.1007/s00262-023-03539-8
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Lisa May Ling Tachiki Daniel S Hippe Karly Williams Silva Evan Thomas Hall William McCamy Dane Fritzsche Andrea Perdue Julia Majovski Thomas Pulliam Daniel A Goldstein Joshua Veatch Joel Ho Paul T Nghiem John A Thompson Shailender Bhatia Source Type: research
Changes in the proportion of lymphocyte subsets and the expression of surface receptors in peripheral blood of patients with colorectal cancer
Conclusion There are differences in the proportion of NK cell subsets and the expression profile of surface receptors in peripheral blood of patients with colorectal cancer.PMID:37732579
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Yihua Hui Haina Wang Yani Cui Yijun Duan Laifeng Ren Wen Su Source Type: research
Boiling histotripsy induces dendritic cell activation and acquisition of antigen in tumor draining lymph nodes
bioRxiv. 2023 Sep 6:2023.09.02.552844. doi: 10.1101/2023.09.02.552844. Preprint.ABSTRACTBoiling histotripsy (BH), a mechanical focused ultrasound ablation strategy, can elicit intriguing signatures of anti-tumor immunity. However, the influence of BH on dendritic cell function is unknown, compromising our ability to optimally combine BH with immunotherapies to control metastatic disease. Here, by applying BH to B16F10 melanoma expressing a ZsGreen antigen in a monotherapy protocol that elicits abscopal tumor control, we observed a marked increase in antigen acquisition by multiple phagocytic immune cells, including convent...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Eric A Thim Lydia E Petricca F átima Rivera-Escalera Alexander S Mathew Michael R Elliott Timothy N J Bullock Richard J Price Source Type: research
Clinical outcomes of ramucirumab plus docetaxel in the treatment of patients with non-small cell lung cancer after immunotherapy: a systematic literature review
CONCLUSIONS: Cumulatively, these results support the combination of ramucirumab plus docetaxel as an effective and safe subsequent therapy for the treatment of patients with metastatic NSCLC with disease progression irrespective of previous ICI treatment.PMID:37731641 | PMC:PMC10507469 | DOI:10.3389/fonc.2023.1247879
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Edward B Garon Carla Visseren-Grul Maria Teresa Rizzo Tarun Puri Suresh Chenji Martin Reck Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
medRxiv. 2023 Sep 7:2023.09.05.23295093. doi: 10.1101/2023.09.05.23295093. Preprint.ABSTRACTClonal hematopoiesis (CH), characterized by blood cells predominantly originating from a single mutated hematopoietic stem cell, is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CH is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk in Communities Study (ARIC) participants over a me...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Md Mesbah Uddin Seyedmohammad Saadatagah Abhishek Niroula Bing Yu Whitney Hornsby Shriienidhie Ganesh Kim Lannery Art Shuermans Michael C Honigberg Alexander G Bick Peter Libby Benjamin L Ebert Christie M Ballantyne Pradeep Natarajan Source Type: research
Cardiac microRNAs: diagnostic and therapeutic potential
Arch Med Sci. 2023 Aug 25;19(5):1360-1381. doi: 10.5114/aoms/169775. eCollection 2023.ABSTRACTMicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. In cardiovascular disease pathophysiology, there are several cells that produce microRNAs, including endothelial cells, vascular smooth muscle cells, macrophages, platelets, and cardiomyocytes. There is a constant crosstalk between microRNAs derived from variou...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Anna Kab łak-Ziembicka Rafa ł Badacz Micha ł Okarski Magdalena Wawak Tadeusz Przew łocki Jakub Podolec Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: A case report and literature review
CONCLUSION: Based on pathological and genetic analysis, surgery combined with chemotherapy or chemoradiotherapy may have good therapeutic effects for collision tumor.PMID:37731579 | PMC:PMC10507543 | DOI:10.12998/wjcc.v11.i26.6289
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Meng Jiang Xiao-Ping Yuan Source Type: research
Research Progress and New Perspectives of Anticancer Effects of Emodin
In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.PMID:37732372 | DOI:10.1142/S0192415X23500787
Source: The American Journal of Chinese Medicine - September 21, 2023 Category: Complementary Medicine Authors: Wu Liu Eskandar Qaed Yuelin Zhu Wenzhang Tian Yizhen Wang Le Kang Xiaodong Ma Zeyao Tang Source Type: research
Down-regulation of interleukin-2 predicts poor prognosis and associated with immune escape in lung adenocarcinoma
Conclusion: Our results indicate that down-regulation of IL2 predicts poor prognosis and is associated with immune escape in LUAD, and IL2 could serve as a potential novel prognostic biomarker of LUAD.PMID:37731383 | DOI:10.1177/03946320231202748
Source: International Journal of Immunopathology and Pharmacology - September 21, 2023 Category: Allergy & Immunology Authors: Yongwang Hou Baoli Xiang Zhicong Yang Jiangmin Liu Dandan Xu Lina Geng Minghua Zhan Yuhuan Xu Bin Zhang Source Type: research
