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Total 1980994 results found since Jan 2013.
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research
Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/ β-catenin pathway in atherosclerosis
In this study, ApoE-/-: Sirt6-/- and ApoE-/-: Sirt6Tg mice were used and lipid droplets were analysed via transmission electron microscopy and Bodipy 493/503 staining in vitro. Atherosclerotic plaques in ApoE-/-: Sirt6-/- mice showed greater necrotic cores and lower stability score. Reconstitution of Sirt6 in atherosclerotic mice improved lipid metabolism disorder and prevented the progression of atherosclerosis. Furthermore, macrophages with Ac-LDL intervention showed more lipid droplets and increased expression of adipophilin and PLIN2. Reconstitution of Sirt6 recruited using SNF2H suppressed Wnt1 expression and improved...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Tingting Wang Zheng Cheng Ran Zhao Jin Cheng He Ren Pengke Zhang Pengyun Liu Qimeng Hao Qian Zhang Xiaolei Yu Dongdong Sun Dongwei Zhang Source Type: research
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Colorectal Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research
Oncologic outcomes of segmentectomy versus lobectomy for clinical T1c radiological pure-solid non-small cell lung cancer
CONCLUSIONS: In T1c radiological pure-solid non-small cell lung cancer, segmentectomy was significantly associated with worse survival and insufficient loco-regional cancer control. Lobectomy remains the standard surgical treatment; meanwhile, segmentectomy should be applied with great caution.PMID:37738593 | DOI:10.1093/icvts/ivad152
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Aritoshi Hattori Kazuya Takamochi Takeshi Matsunaga Mariko Fukui Kenji Suzuki Source Type: research
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 < sup > + < /sup > T cell formation
Sci Immunol. 2023 Sep 29;8(87):eadf7579. doi: 10.1126/sciimmunol.adf7579. Epub 2023 Sep 22.ABSTRACTMitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highli...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fabien Franco Alessio Bevilacqua Ruey-Mei Wu Kung-Chi Kao Chun-Pu Lin Lor ène Rousseau Fu-Ti Peng Yu-Ming Chuang Jhan-Jie Peng Jaeoh Park Yingxi Xu Antonino Cassotta Yi-Ru Yu Daniel E Speiser Federica Sallusto Ping-Chih Ho Source Type: research
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research
Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
CONCLUSION: Cryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy.PMID:37736543 | PMC:PMC10509548 | DOI:10.3389/fonc.2023.1185291
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiaqiang Wang Dengwei Zong Shuping Dong Shilei Gao Yonghao Yang Peng Zhang Xin Wang Weitao Yao Zhichao Tian Source Type: research
Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research
Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
CONCLUSION: Although NK cell therapy could effectively decrease the mitotic count in vivo, the obtained findings indicated lesser potency than MC despite ex vivo activation. In order to enhance NK cell therapy effectiveness, suppressive features of the tumor microenvironment and inhibitory immune checkpoints blockade should be considered.PMID:37736341 | PMC:PMC10509737 | DOI:10.34172/bi.2022.26386
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zeinab Ghazvinian Shahrokh Abdolahi Mohammad Ahmadvand Amir Hossein Emami Samad Muhammadnejad Hamid Asadzadeh Aghdaei Jafar Ai Mohammad Reza Zali Iman Seyhoun Javad Verdi Kaveh Baghaei Source Type: research
Activity of pazopanib in < em > EWSR1-NFATC2 < /em > translocation-associated bone sarcoma
Oncoscience. 2023 Sep 20;10:44-53. doi: 10.18632/oncoscience.587. eCollection 2023.ABSTRACTPazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.PMID:37736255 | PMC:PMC10511123 | DOI:10.18632/oncoscience.587
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Maria A Zarzour Ara A Vaporciyan Kalevi Kairemo Hubert H Chuang Vivek Subbiah Source Type: research
METTL5-mediated 18S rRNA m < sup > 6 < /sup > A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Mol Ther. 2023 Sep 20:S1525-0016(23)00501-4. doi: 10.1016/j.ymthe.2023.09.014. Online ahead of print.ABSTRACTIntrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive. Here, we found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (Log rank test, p<0.05). We further revealed the critical role of METTL5-mediated 18S rRNA m6A modification in regulation...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zihao Dai Wanjie Zhu Yingdong Hou Xinyue Zhang Xuxin Ren Kai Lei Junbin Liao Haining Liu Zhihang Chen Sui Peng Shaoqiang Li Shuibin Lin Ming Kuang Source Type: research
