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Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research

Photoactivatable base editors for spatiotemporally controlled genome editing in vivo
This study opens a promising way to improve the operability, safety, and precision of base editing.PMID:37722184 | DOI:10.1016/j.biomaterials.2023.122328
Source: Biomaterials - September 18, 2023 Category: Materials Science Authors: Quan Zou Yi Lu Bo Qing Na Li Ting Zhou Jinbin Pan Xuejun Zhang Xuening Zhang Yupeng Chen Shao-Kai Sun Source Type: research

Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses
Biomaterials. 2023 Sep 13;302:122329. doi: 10.1016/j.biomaterials.2023.122329. Online ahead of print.ABSTRACTAlthough rapamycin is a very effective drug for rodents with polycystic kidney disease (PKD), it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off-target side effects. We here report the generation, characterization, specificity, functionality, pharmacokinetic, pharmacodynamic and toxicology profiles of novel polycystic kidney-specific-targeting nanoparticles (NPs). We formulated folate-conjugated PLGA-PEG NPs, which can be loaded with multiple drugs, including rapamycin (a...
Source: Biomaterials - September 18, 2023 Category: Materials Science Authors: Rajasekharreddy Pala Ayan K Barui Ashraf M Mohieldin Jing Zhou Surya M Nauli Source Type: research

Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives
Future Microbiology, Ahead of Print.
Source: Future Microbiology - September 18, 2023 Category: Microbiology Authors: Alessandro F Valdez Daniel Zamith-Miranda Leonardo Nimrichter Joshua D Nosanchuk Source Type: research

Molecules, Vol. 28, Pages 6687: Copper and Copper-Based Nanoparticles in Medicine & mdash;Perspectives and Challenges
This article aims to provide contemporary insights into the perspectives and challenges regarding the use of copper and copper oxide nanoparticles in medicine. It summarises the biomedical potential of copper-based nanoformulations, including the progress of early-stage research, to evaluate and mitigate the potential toxicity of copper nanomaterials. The discussion covers the challenges and prospects of copper-based nanomaterials in the context of their successful clinical translation. The article also addresses safety concerns, emphasizing the need for toxicity assessments of nanomedicines. However, attention is needed t...
Source: Molecules - September 18, 2023 Category: Chemistry Authors: Marta J. Wo źniak-Budych Katarzyna Staszak Maciej Staszak Tags: Review Source Type: research

Molecules, Vol. 28, Pages 6685: Relation between Conventional and Starch-Assisted ASP Injection and Impact of Crystallinity on Flood Formation
This study explores conventional ASP flooding using PT SPR Langgak’s special surfactants, simulating Langgak oilfield conditions in Sumatra, Indonesia. By comparing the outcomes of this flooding technique with that of starch-assisted ASP performed in another study, the benefits of adding starch nanoparticles to flooding are evident. Nano-starch ASP increased oil recovery by 18.37%, 10.76%, and 10.37% for the three configurations investigated in this study. Water flooding preceded ASP flooding, and flooding operations were carried out at 60 °C. This study employed sodium hydroxide (NaOH), sodium ca...
Source: Molecules - September 18, 2023 Category: Chemistry Authors: Hasanain A. Al-Jaber Agus Arsad Sulalit Bandyopadhyay Mohd Zaidi Jaafar Muhammad Tahir Mustafa Jawad Nuhma Abdulmunem R. Abdulmunem Mohammad Yasin Abdulfatah Hajar Alias Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6676: Palladium Nanoparticles Grafted onto Phytochemical Functionalized Biochar: A Sustainable Nanozyme for Colorimetric Sensing of Glucose and Glutathione
A. Patil The devising and development of numerous enzyme mimics, particularly nanoparticles and nanomaterials (nanozymes), have been sparked by the inherent limitations imposed by natural enzymes. Peroxidase is one of the enzymes that is extensively utilized in commercial, medical, and biological applications because of its outstanding substrate selectivity. Herein, we present palladium nanoparticles grafted on Artocarpus heterophyllus (jackfruit) seed-derived biochar (BC-AHE@Pd) as a novel nanozyme to imitate peroxidase activity en route to the rapid and colorimetric detection of H2O2, exploiting o-phenylenediamine a...
Source: Molecules - September 18, 2023 Category: Chemistry Authors: Aakhila Banu Arnet Maria Antony Balappa Somappa Sasidhar Shivaputra A. Patil Siddappa A. Patil Tags: Article Source Type: research

Computational Assessment of Unsteady Flow Effects on Magnetic Nanoparticle Targeting Efficiency in a Magnetic Stented Carotid Bifurcation Artery
ConclusionThe simulation results presented in this work have shown to yield favorable capture efficiencies for micron range particles and superparamagnetic particles using magnetized implants such as the stent discussed in this work. The results presented in this work justify further investigation of MDT as a treatment technique for cardiovascular disease.
Source: Cardiovascular Engineering and Technology - September 18, 2023 Category: Cardiology Source Type: research

Detection of hemolytic Shiga toxin-producing Escherichia coli in fresh vegetables and efficiency of phytogenically synthesized silver nanoparticles by Syzygium aromaticum extract and gamma radiation against isolated pathogens
Shiga toxin-producing E. coli (STEC) is a major cause of foodborne diseases accompanied by several clinical illnesses in humans. This research aimed to isolate, identify, and combat STEC using novel alternative t...
Source: BMC Microbiology - September 18, 2023 Category: Microbiology Authors: Hanan S. El-Bastawisy, Gharieb S. El-Sayyad and Feriala A. Abu Safe Tags: Research Source Type: research

Effect of poly (lactic-co-glycolic acid) polymer nanoparticles loaded with vancomycin against Staphylococcus aureus biofilm
Staphylococcus aureus is a unique challenge for the healthcare system because it can form biofilms, is resistant to the host's immune system, and is resistant to numerous antimicrobial therapies. The aim of this ...
Source: BMC Biotechnology - September 18, 2023 Category: Biotechnology Authors: Ellahe Nouruzi, Seyed Mostafa Hosseini, Babak Asghari, Reza Mahjoub, Ehsan Nazarzadeh Zare, Mohammad-Ali Shahbazi, Fereshte Kalhori and Mohammad Reza Arabestani Tags: Research Source Type: research

Probability of Cavitation in a Custom Iron-Based Coupling Medium for Transcranial Magnetic Resonance-Guided Focused Ultrasound Procedures
A coupling bath of circulating, chilled, degassed water is essential to safe and precise acoustic transmittance during transcranial magnetic resonance-guided focused ultrasound (tMRgFUS) procedures, but the circulating water impairs the critical real-time magnetic resonance imaging (MRI). An iron-based coupling medium (IBCM) using iron oxide nanoparticles previously developed by our group increased the relaxivity of the coupling bath such that it appears to be invisible on MRI compared with degassed water.
Source: Ultrasound in Medicine and Biology - September 18, 2023 Category: Radiology Authors: Connor Edsall, Austin Fergusson, Richey M. Davis, Craig H. Meyer, Steven P. Allen, Eli Vlaisavljevich Tags: Original Contribution Source Type: research

Effervescent tablet-assisted deep eutectic solvent based on magnetic nanofluid for liquid phase microextraction of tyrosine kinase inhibitors in plasma samples by high-performance liquid chromatography
CONCLUSIONS: The developed method displayed high sensitivity, low consumption of solvent, low cost, simplicity, high recoveries, short extraction time, and good repeatability for determination of three anti-cancer drugs in human plasma samples.PMID:37717246 | DOI:10.1007/s43440-023-00524-x
Source: Pharmacological Reports - September 17, 2023 Category: Drugs & Pharmacology Authors: Khosrou Abdi Maryam Ezoddin Laleh Adlnasab Bahar Aziz Kabiri Mohammad Ali Karimi Somaye Behnamipour Houman Alimoradi Source Type: research

Green synthesis of multifunctional zinc oxide nanoparticles from cordia myxa gum; and their catalytic reduction of nitrophenol, anticancer and antimicrobial activity
This study uses CMX gum as a bioreduction to produce multifunctional, environmentally friendly zinc-oxide nanocomposites (ZnO NPs). The process involves a low reaction time and temperature and utilizes CMX as a reducing and stabilizing agent. The structural, morphological, and optical properties of the CMX-ZnO nanocomposite were characterized. The biosynthetic CMX-ZnO NPs exhibited robust catalytic activity and recycling capacity for rapidly oxidizing hazardous p-NPs. The complete reduction of 4-NP to CMX-ZnO NPs in excess NaBH4 was achieved within 15 min, with recyclability and pseudo-first-order kinetics with a rate cons...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Kasula Nagaraja O H Tae Hwan Source Type: research

A new SERS quantitative analysis method for trace malathion with recognition and catalytic amplification difunctional MOF < sub > Tb < /sub > @Au@MIP nanoprobe
Talanta. 2023 Sep 13;267:125166. doi: 10.1016/j.talanta.2023.125166. Online ahead of print.ABSTRACTNew multifunctional nanomaterial preparation and its application to trace pollutant analysis are interesting to peoples. Using terbium metal-organic framework loaded gold nanoparticles (MOFTb@Au) as the nanosubstrate and 3-aminopropyltriethoxysilane (APTES) as the functional monomer, a new bifunctional nanosurface molecularly imprinted polymer nanoprobe of MOFTb@Au@MIP with strongly recognition and catalytic amplification functions was prepared by the microwave sol-gel procedure. It was characterized by scanning electron micr...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Yiyi Shu Jingjing Li Hongyan Bai Aihui Liang Guiqing Wen Zhiliang Jiang Source Type: research

Ultrastructural characteristics of the accumulation of iron nanoparticles in the intestine of Cyprinus carpio (Linnaeus, 1758) under aquaculture
Ecotoxicol Environ Saf. 2023 Sep 15;264:115477. doi: 10.1016/j.ecoenv.2023.115477. Online ahead of print.ABSTRACTDuring the development of nanotechnology, the production of many substances containing nanoparticles leads to the release of various nanoparticles into the environment, including the water ecosystem. The main goal of the current research was to study the ultrastructural characteristics of the entry and bioaccumulation of Fe3O4 nanoparticles in the small intestine of Cyprinus carpio (Linnaeus, 1758), as well as the pathomorphological changes in the fish organism. Two different doses (10 and 100 mg) of Fe3O4 nanop...
Source: Ecotoxicology and Environmental Safety - September 17, 2023 Category: Environmental Health Authors: Aysel Hajiyeva Chingiz Mamedov Eldar Gasimov Fuad Rzayev Rovshan Khalilov Elham Ahmadian Aziz Eftehari William C Cho Source Type: research