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Total 150319 results found since Jan 2013.
Stepwise Au decoration-assisted double signal amplified lateral flow strip for ultrasensitive detection of morphine in fingerprint sweat
In this study, ultrasensitive and non-invasive screening of MOP residues in the fingerprint sweat was easily realized by stepwise Au decoration-assisted double signal amplification and antibody-saving strategies on lateral flow strip (LFS). The construction of LFS was not intrinsically changed compared with traditional LFS except the labeling material on conjugation pad for enhanced signal reporting. The gold nanoparticle-seeded SiO2 was adopted as the labeling materials in place of traditional gold nanoparticles, which acted as the first-round signal amplification and ready for second-round gold deposition-assisted amplif...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Qi Chen Li Yao Jianguo Xu Qiujing Qi Sha Tao Xin Song Wei Chen Source Type: research
Palladium-based multifunctional nanoparticles for combined chemodynamic/photothermal and calcium overload therapy of tumors
In this study, calcium carbonate-modified palladium hydride nanoparticles (PdH@CaCO3) were prepared and utilized for the combined treatment of tumors through chemodynamic therapy (CDT)/photothermal therapy (PTT) and calcium overload therapy. After entering tumor cells, PdH@CaCO3 releases calcium ions (Ca2+) and PdH once it reaches the TME due to the pH reactivity of the calcium carbonate coating. The mitochondrial membrane potential is lowered by the Ca2+, leading to irreversible cell damage. Meanwhile, PdH reacts with excessive hydrogen peroxide (H2O2) in the TME via the Fenton reaction, generating hydroxyl radicals (·OH...
Source: Colloids and Surfaces - September 14, 2023 Category: Biotechnology Authors: Wenge Zhang Jiangyong Li Lamei Chen Huan Chen Liangke Zhang Source Type: research
Nanoparticles as a younger member of the trace element species family - a food perspective
This article presents and discusses the current trends in analysis of nanoparticle behaviour in the gastrointestinal tract and formation and characterisation of biogenic nanoparticles.PMID:37709980 | DOI:10.1007/s00216-023-04940-z
Source: Analytical and Bioanalytical Chemistry - September 14, 2023 Category: Chemistry Authors: Zuzana Gajdosechova Katrin Loeschner Source Type: research
Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers
Biomaterials. 2023 Sep 6;302:122318. doi: 10.1016/j.biomaterials.2023.122318. Online ahead of print.ABSTRACTNanoparticle-based drug delivery systems (DDS) have shown promising results in reversing hepatic fibrosis, a common pathological basis of chronic liver diseases (CLDs), in preclinical animal models. However, none of these nanoparticle formulations has transitioned to clinical usage and there are currently no FDA-approved drugs available for liver fibrosis. This highlights the need for a better understanding of the challenges faced by nanoparticles in this complex disease setting. Here, we have systematically studied ...
Source: Biomaterials - September 14, 2023 Category: Materials Science Authors: Arunpandian Balaji Craig A Bell Zachary H Houston Kim R Bridle Berit Genz Nicholas L Fletcher Grant A Ramm Kristofer J Thurecht Source Type: research
Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity
Acta Pharm. 2023 Sep 14;73(3):457-473. doi: 10.2478/acph-2023-0028. Print 2023 Sep 1.ABSTRACTRiolozatrione (RZ) is a diterpenoid compound isolated from a dichloromethane extract of the Jatropha dioica root. This compound has been shown to possess moderate antiherpetic activity in vitro. However, because of the poor solubility of this compound in aqueous vehicles, generating a stable formulation for potential use in the treatment of infection is challenging. The aim of this work was to optimize and physio-chemically characterize Eudragit® L100-55-based polymeric nanoparticles (NPs) loaded with RZ (NPR) for in vitro antiher...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Guadalupe Y Sol ís-Cruz Roc ío Alvarez-Roman Ver ónica M Rivas-Galindo Sergio Arturo Galindo-Rodr íguez David A Silva-Mares Iv án A Marino-Martínez Magdalena Escobar-Saucedo Luis A P érez-López Source Type: research
Enrichment of sialic acid-containing casein glycomacropeptide in protein hydrolysates using phenylboronic acid-functionalized mesoporous silica nanoparticles
Talanta. 2023 Sep 9;267:125174. doi: 10.1016/j.talanta.2023.125174. Online ahead of print.ABSTRACTGlycomacropeptide (GMP) is a bioactive peptide of high value, rich in glycosylation sites and with physiological and dietary therapeutic value. The enrichment and detection of GMP facilitates the accurate quantification and the identification of adulteration of GMP in food products. In GMP, sialic acid is an abundant glycosyl group and is mainly located at the end of the sugar chain. Here, we propose a novel GMP enrichment strategy based on the affinity of sialic acid for phenylboronic acid groups that shift with environmental...
Source: Talanta - September 14, 2023 Category: Chemistry Authors: Chenhui Lu Haodong Wei Lizhi Xu Wen-Long Wang Cheng Yang Xueli Shi Hui Gao Yong-Wei Feng Jianzhong Zhou Yi Zhang Source Type: research
Shape Control of Carbon Nanoparticles via Simple Anion-Directed Strategy for Precise Endoplasmic Reticulum-Targeted Imaging
Angew Chem Int Ed Engl. 2023 Sep 14:e202311008. doi: 10.1002/anie.202311008. Online ahead of print.ABSTRACTHerein, small-sized fluorescent carbon nanoparticles (CNs) with tunable shapes ranging from spheres to various rods with aspect ratios (ARs) of 1.00, 1.51, 1.89, and 2.85 are prepared using a simple anion-directed strategy for the first time. And based on comprehensive morphological and structural characteristics of CNs, along with theoretical calculations of density functional theory and molecular dynamics simulations, their shape-control mechanism is attributed to interionic interactions-induced self-assembly, follo...
Source: Angewandte Chemie - September 14, 2023 Category: Chemistry Authors: Shuang E YanZhi Xing Sang Du AnMin Liu Zhao Gao Quan Zhou Yang Xuan YiNan Zhao XuWei Chen Shubiao Zhang Source Type: research
A Nanomedicine-Enabled Ion-Exchange Strategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy
Angew Chem Int Ed Engl. 2023 Sep 14:e202310061. doi: 10.1002/anie.202310061. Online ahead of print.ABSTRACTCurcumin (Cur) has been clinically used for rheumatoid arthritis treatment by the means of reactive oxygen species (ROS) scavenging and immune microenvironment regulation. However, this compound has a poor water solubility and moderate antioxidative activity, favoring no further broadened application. Metal complexes of curcumin such as zinc-curcumin (Zn-Cur) features enhanced water solubilities, while copper-curcumin (Cu-Cur) shows a higher antioxidant activity but lower solubility than Zn-Cur. Based on their inheren...
Source: Angewandte Chemie - September 14, 2023 Category: Chemistry Authors: Jiacai Yang Bowen Yang Jianlin Shi Source Type: research
Dumbbell hybridization chain reaction coupled with positively charged Au@luminol nanoparticles for enhanced electrochemiluminescent sensing of exosomal miRNA-21
Bioelectrochemistry. 2023 Sep 6;155:108556. doi: 10.1016/j.bioelechem.2023.108556. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are important cancer biomarkers in cancer cell-derived exosomes. Herein, positively charged Au@luminol nanoparticles ((+)Au@luminol NPs) with enhanced electrochemiluminescence (ECL) and extreme stability were firstly established for the sensitive detection of miRNA-21 in exosome. In the presence of miRNA-21, dumbbell hybridization chain reaction (DHCR) happened at gold nanoparticles and ZIF-67 metal-organic framework modified glass carbon electrode (AuNP/ZIF-MOF/GCE) with the help of dumbbell ...
Source: Bioelectrochemistry - September 14, 2023 Category: Biochemistry Authors: Yun Zhang Shiqiang Li Chenxu Peng Zhe Shi Xiangmin Miao Source Type: research
Pair Distribution Functions from Liquid Jet Nanoparticle Suspensions using Femtosecond X-ray Pulses
Chemphyschem. 2023 Sep 13:e202300407. doi: 10.1002/cphc.202300407. Online ahead of print.ABSTRACTX-ray scattering data measured on femtosecond timescales at the SACLA X-ray Free Electron Laser (XFEL) facility on a suspension of HfO2 nanoparticles in a liquid jet were used for Pair Distribution Function (PDF) analysis. Despite a non-optimal experimental setup, resulting in a modest Qmax of ~8 Å-1, a promising PDF was obtained. The main structural features were reproduced when comparing the XFEL PDF to a PDF obtained from data measured at the PETRA III synchrotron source. Refining structural parameters such as unit cell dim...
Source: Chemphyschem - September 14, 2023 Category: Chemistry Authors: Lise St øckler Rasmus Christensen Magnus Kloeve Andreas Dueholm Bertelsen Anders Baek Borup Lennard Krause Seyia Takahashi Tomoki Fujita Hidetaka Kasai Ichiro Inoue Eiji Nishibori Bo Brummerstedt Iversen Source Type: research
Self-Immolative Polymer Nanoparticles with Precise and Controllable pH-Dependent Degradation
Biomacromolecules. 2023 Sep 14. doi: 10.1021/acs.biomac.3c00630. Online ahead of print.ABSTRACTPolymer nanoparticles have generated significant interest as delivery systems for therapeutic cargo. Self-immolative polymers (SIPs) are an interesting category of materials for delivery applications, as the characteristic property of end-to-end depolymerization allows for the disintegration of the delivery system, facilitating a more effective release of the cargo and clearance from the body after use. In this work, nanoparticles based on a pH-responsive polymer poly(ethylene glycol)-b-(2-diisopropyl)amino ethyl methacrylate) an...
Source: Biomacromolecules - September 14, 2023 Category: Biochemistry Authors: Samuel A Smith Bruna Rossi Herling Changhe Zhang Maximilian A Beach Serena L Y Teo Elizabeth R Gillies Angus P R Johnston Georgina K Such Source Type: research
Effect of the magnetic core in alginate/gum composite on adsorption of divalent copper, cadmium, and lead ions in the aqueous system
Int J Biol Macromol. 2023 Sep 12:126884. doi: 10.1016/j.ijbiomac.2023.126884. Online ahead of print.ABSTRACTThe change of composition of an adsorbent material has been widely used as a method to increase its adsorption capacity, particularly concerning adsorbents made of polysaccharides. Introducing magnetic adsorbents into contaminated water treatment systems is a highly promising strategy, as it promotes the metal ions removal from water. Considering this, gum Arabic (GA) was associated with alginate (Alg), when magnetite nanoparticles were present or absent, to produce beads that were utilised to take up Cu(II), Cd(II),...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Khalid Z Elwakeel Marwan M Ahmed Abdullah Akhdhar Huda M Alghamdi Mohamed G M Sulaiman Mohammed F Hamza Ziya A Khan Source Type: research
Prospecting the cancer therapeutic edge of chitosan-based gold nanoparticles through conformation selective binding to the parallel G-quadruplex formed by short telomeric DNA sequence: A multi-spectroscopic approach
Int J Biol Macromol. 2023 Sep 12:126835. doi: 10.1016/j.ijbiomac.2023.126835. Online ahead of print.ABSTRACTThe biological relevance of G4 structures formed in telomere & oncogenes promoters make them extremely crucial therapeutic target for cancer treatment. Herein, we have synthesized chitosan-based gold nanoparticles (CH-Au NPs) through green method and investigated their interaction with G4 structures formed by short telomeric sequences to evaluate their potential for targeting G4 structures. Firstly, we have characterized morphological/physical attributes of synthesized CH-Au NPs and salt dependent structural aspe...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: None Sonia Shrikant Kukreti Mahima Kaushik Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
