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Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity
Acta Pharm. 2023 Sep 14;73(3):457-473. doi: 10.2478/acph-2023-0028. Print 2023 Sep 1.ABSTRACTRiolozatrione (RZ) is a diterpenoid compound isolated from a dichloromethane extract of the Jatropha dioica root. This compound has been shown to possess moderate antiherpetic activity in vitro. However, because of the poor solubility of this compound in aqueous vehicles, generating a stable formulation for potential use in the treatment of infection is challenging. The aim of this work was to optimize and physio-chemically characterize Eudragit® L100-55-based polymeric nanoparticles (NPs) loaded with RZ (NPR) for in vitro antiher...
Source: Herpes - September 14, 2023 Category: Infectious Diseases Authors: Guadalupe Y Sol ís-Cruz Roc ío Alvarez-Roman Ver ónica M Rivas-Galindo Sergio Arturo Galindo-Rodr íguez David A Silva-Mares Iv án A Marino-Martínez Magdalena Escobar-Saucedo Luis A P érez-López Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
Infrared pulsed fiber laser-produced gold and silver-109 nanoparticles for laser desorption/ionization mass spectrometry of steroid hormones
CONCLUSION: The results of the quantitative analysis of steroid hormones using silver-109 and gold nanoparticles prepared with PFL 2D GS LGN for LDI-MS and semiautomatic LDI-MSI are presented. It has been proven that nanoparticles obtained by laser synthesis can be successfully used for the analysis of steroid hormones in a wide range of concentrations.PMID:37706428 | DOI:10.1002/rcm.9621
Source: Rapid Communications in Mass Spectrometry : RCM - September 14, 2023 Category: Chemistry Authors: Aneta P łaza-Altamer Artur Ko łodziej Zuzanna Krupa Joanna Nizio ł Tomasz Ruman Source Type: research
Nose-to-Brain Delivery of Hesperidin Nanoparticles Loaded In-Situ Gel for Neuroprotective Action
CONCLUSION: This study showed the potential of HSP NPs to be an effective neuroprotective agent.PMID:37708993 | DOI:10.1016/j.pharma.2023.09.001
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Suraj Bamankar Vaishali Londhe Source Type: research
Effect of the magnetic core in alginate/gum composite on adsorption of divalent copper, cadmium, and lead ions in the aqueous system
Int J Biol Macromol. 2023 Sep 12:126884. doi: 10.1016/j.ijbiomac.2023.126884. Online ahead of print.ABSTRACTThe change of composition of an adsorbent material has been widely used as a method to increase its adsorption capacity, particularly concerning adsorbents made of polysaccharides. Introducing magnetic adsorbents into contaminated water treatment systems is a highly promising strategy, as it promotes the metal ions removal from water. Considering this, gum Arabic (GA) was associated with alginate (Alg), when magnetite nanoparticles were present or absent, to produce beads that were utilised to take up Cu(II), Cd(II),...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Khalid Z Elwakeel Marwan M Ahmed Abdullah Akhdhar Huda M Alghamdi Mohamed G M Sulaiman Mohammed F Hamza Ziya A Khan Source Type: research
Prospecting the cancer therapeutic edge of chitosan-based gold nanoparticles through conformation selective binding to the parallel G-quadruplex formed by short telomeric DNA sequence: A multi-spectroscopic approach
Int J Biol Macromol. 2023 Sep 12:126835. doi: 10.1016/j.ijbiomac.2023.126835. Online ahead of print.ABSTRACTThe biological relevance of G4 structures formed in telomere & oncogenes promoters make them extremely crucial therapeutic target for cancer treatment. Herein, we have synthesized chitosan-based gold nanoparticles (CH-Au NPs) through green method and investigated their interaction with G4 structures formed by short telomeric sequences to evaluate their potential for targeting G4 structures. Firstly, we have characterized morphological/physical attributes of synthesized CH-Au NPs and salt dependent structural aspe...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: None Sonia Shrikant Kukreti Mahima Kaushik Source Type: research
Dietary Effects of Selenium Nanoparticles on Growth Performance, Survival Rate, Chemical Composition, and Muscle Bioaccumulation of Nile Tilapia (Oreochromis niloticus)
This study evaluated the effect of selenium nanoparticles on growth performance, survival rate, chemical composition, and bioaccumulation of selenium in the muscle of Nile tilapia (Oreochromis niloticus). Fish with an average weight of 33.1 ± 1.0 g were distributed in 12 fiberglass tanks and fed for 56 days with different levels of selenium nanoparticles, 0, 0.5, 1, and 2 mg/kg of diet, considered as control, T1, T2, and T3, respectively. Body weight increase (BWI), specific growth rate (SGR), and food conversion ratio (FCR) were significantly influenced by 2 mg/kg of selenium nanoparticles compared to the other treatment...
Source: Biological Trace Element Research - September 14, 2023 Category: Biology Authors: Shervin Sheikh Fariborz Ghojaghi Afshin Ghelichi Sarah Jorjani Source Type: research
From lipid nanoparticles to precision therapies for hematologic diseases: getting closer
J Leukoc Biol. 2023 Sep 14:qiad108. doi: 10.1093/jleuko/qiad108. Online ahead of print.NO ABSTRACTPMID:37707301 | DOI:10.1093/jleuko/qiad108
Source: Journal of Leukocyte Biology - September 14, 2023 Category: Hematology Authors: Hector Mayani Source Type: research
Highly selective molecularly imprinted polymer nanoparticles (MIP NPs)-based microfluidic gas sensor for tetrahydrocannabinol (THC) detection
Anal Chim Acta. 2023 Oct 16;1278:341749. doi: 10.1016/j.aca.2023.341749. Epub 2023 Aug 22.ABSTRACTA highly selective microfluidic integrated metal oxide gas sensor for THC detection is reported based on MIP nanoparticles (MIP NPs). We synthesized MIP NPs with THC recognition sites and coated them on a 3D-printed microfluidic channel surface. The sensitivity and selectivity of coated microfluidic integrated gas sensors were evaluated by exposure to THC, cannabidiol (CBD), methanol, and ethanol analytes in 300-700 ppm at 300 °C. For comparison, reference signals were obtained from a microfluidic channel coated with nonimpri...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Peyman Azhdary Sajjad Janfaza Somayeh Fardindoost Nishat Tasnim Mina Hoorfar Source Type: research
An ultrasensitive J-shaped optical fiber LSPR aptasensor for the detection of Helicobacter pylori
In this study, an originally bent structure, named as J-shaped optical fiber probe, was first designed to engineer a localized surface plasmon resonance (LSPR) aptamer biosensor for the rapid and ultrasensitive detection of Helicobacter pylori (H. pylori). The J-shaped optical fiber probe exhibited a significant improvement in refractive index sensitivity (RIS) and LSPR signal response. Meantime, the original sequence of aptamer was truncated in order to effectively capture H. pylori on the optical fiber surface. Besides, a spacer nucleic acid with short stem-loop structure was adopted to control the aptamer density on gol...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wei Ning Shunming Hu Chen Zhou Jie Luo Yu Li Chuyan Zhang Zewei Luo Yongxin Li Source Type: research
A molecularly imprinted screen-printed carbon electrode for electrochemical epinephrine, lactate, and cortisol metabolites detection in human sweat
This study presents a novel approach to the detection of epinephrine, lactate, and cortisol biomarkers in human sweat using molecularly-imprinted polymers (MIP) embedded screen printed carbon electrode (SPCE) sensors. The epinephrine and lactate MIP SPCE sensors were fabricated by epinephrine or lactate-imprinted polyaniline co-polymerized with 3-aminophenylboronic acid and gold nanoparticles (PANI-co-PBA/AuNP) selective membrane on a commercial SPCE. The cortisol sensor was comprised of a cortisol-imprinted poly(glycidyl methacryate-co-ethylene glycol dimethacrylate) (poly (GMA-co-EGDMA)@AuNP selective membrane deposited ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Samuel M Mugo Scott V Robertson Weihao Lu Source Type: research
Development of a novel fluorescent aptasensor based on the interaction between hexagonal β-Co(OH) < sub > 2 < /sub > nanoplates and nitrogen-doped carbon dots for ultrasensitive detection of patulin
In this study, we have developed a novel fluorescent aptasensor that utilizes nitrogen-doped carbon dots (N-CDs) as the fluorescent donor and hexagonal β-Co(OH)2 nanoplates as the fluorescent acceptor. N-CDs were synthesized through the hydrothermal method, resulting in spherical particles with a diameter of 7.6 nm. These nanoparticles exhibited excellent water solubility and displayed a vibrant blue emission at 448 nm when excited at 360 nm. Cobalt hydroxide nanoplates with a beta crystal structure [β-Co(OH)2] were synthesized using a simple co-precipitation method, exhibiting hexagonal plate-like shapes with uniform la...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Qi Sun Zhijuan Li Ningxin Liu Yuting Zhou Fuyan Zhang Shuang Li Peng Jin Rui Xiang Tao Le Source Type: research
Surfactant-mediated colorimetric assay assisted with in-situ rolling circle amplification on magnetic beads
This study offers a new strategy to improve the sensitivity and selectivity for the AuNPs-based colorimetric assay, taking advantages of specific aptamer recognition, in-situ RCA on MBs, magnetic separation, and smartphone-based portable device.PMID:37709452 | DOI:10.1016/j.aca.2023.341709
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Shuang Xia Wenli Wu Fangchao Yin Jianguo Shi Yaohong Ma Jin-Ming Lin Xu Wu Qiongzheng Hu Source Type: research
Molecular imprinted polymer-based potentiometric approach for the assay of the co-formulated tetracycline HCl, metronidazole and bismuth subcitrate in capsules and spiked human plasma
Anal Chim Acta. 2023 Oct 16;1278:341707. doi: 10.1016/j.aca.2023.341707. Epub 2023 Aug 10.ABSTRACTBACKGROUND: An anti-H-pylori co-formulated mixture of tetracycline HCl (TET), metronidazole (MET), and bismuth subcitrate (BSC) is recently available. Only two chromatographic and spectrophotometric methods are reported for determining those drugs simultaneously where the effect of impurities that could be present as well as the biological fluids matrix influence do not be taken into consideration. There is a need to develop an easy-to-use potentiometric technique for analysis of TET, MET, and BSC in their co-formulated capsul...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Amal M Hassan Khadiga M Kelani Maha A Hegazy Mahmoud A Tantawy Source Type: research
Stepwise Au decoration-assisted double signal amplified lateral flow strip for ultrasensitive detection of morphine in fingerprint sweat
In this study, ultrasensitive and non-invasive screening of MOP residues in the fingerprint sweat was easily realized by stepwise Au decoration-assisted double signal amplification and antibody-saving strategies on lateral flow strip (LFS). The construction of LFS was not intrinsically changed compared with traditional LFS except the labeling material on conjugation pad for enhanced signal reporting. The gold nanoparticle-seeded SiO2 was adopted as the labeling materials in place of traditional gold nanoparticles, which acted as the first-round signal amplification and ready for second-round gold deposition-assisted amplif...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Qi Chen Li Yao Jianguo Xu Qiujing Qi Sha Tao Xin Song Wei Chen Source Type: research
