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Enhanced Photoacoustic Imaging of Urokinase-Type Plasminogen Activator Activity in Tumors
Anal Chem. 2023 Sep 18. doi: 10.1021/acs.analchem.3c03305. Online ahead of print.ABSTRACTPhotoacoustic (PA) imaging of urokinase-type plasminogen activator (uPA) activity in vivo holds high promise for early diagnosis of breast cancer. Molecular probes with resisted fluorescence (FL) emission for enhanced PA signals of uPA activity have not been reported. Herein, we proposed a molecular probe Cbz-Gly-Gly-Arg-Phe-Phe-IR775 (Z-GGRFF-IR775) which, upon uPA cleavage, assembled into nanoparticles FF-IR775-NP with quenched fluorescence but enhanced PA signals. Experimental results validated that, upon uPA activation, Z-GGRFF-IR7...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Xinyi Hu Xianbao Sun Xiaoyang Liu Hai-Dong Xu Liang Yang Songqin Liu Rui Wang Gaolin Liang Source Type: research
Stimuli-Responsive Codelivery System Self-Assembled from < em > in Situ < /em > Dynamic Covalent Reaction of Macrocyclic Disulfides for Cancer Magnetic Resonance Imaging and Chemotherapy
ACS Appl Mater Interfaces. 2023 Sep 18. doi: 10.1021/acsami.3c10245. Online ahead of print.ABSTRACTSupramolecular self-assembly has gained increasing attention to construct multicomponent drug delivery systems for cancer diagnosis and therapy. Despite that these self-assembled nanosystems present surprising properties beyond that of each subcomponent, the spontaneous nature of co-self-assembly causes significant difficulties in control of the synthesis process and consequently leads to unsatisfactory influences in downstream applications. Hence, we utlized an in situ dynamic covalent reaction based on thiol-disulfide excha...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Xiaoxia Wu Dinghu Zhang Ting Pan Jianwei Li Yujiao Xie Chenguang Zhang Chunshu Pan Zhewei Zhang Jie Lin Aiguo Wu Guoliang Shao Source Type: research
Fabrication of a Novel Co/CoO@Fe2V4O13 Composite Catalyst as a Photoanode for Enhanced Photoelectrochemical Water Oxidation
Chem Asian J. 2023 Sep 18:e202300537. doi: 10.1002/asia.202300537. Online ahead of print.ABSTRACTHerein, the synthesis of a novel composite photocatalyst, Co/CoO@Fe2V4O13, is reported by the deposition of CoO metal oxide nanoparticles on the surface of Fe2V4O13 bimetallic oxide. The synthesised photocatalyst exhibited a band gap of roughly 1.8 eV, rendering it responsive to the complete visible light spectrum of the sun, thereby enabling optimal absorption of solar radiation. The Co/CoO@Fe2V4O13 composites demonstrated an enhanced photoelectrochemical water oxidation capacity compared to pristine Fe2V4O13 when exposed to v...
Source: Chemistry, an Asian Journal - September 18, 2023 Category: Chemistry Authors: Mohd Asim Abuzar Khan Source Type: research
Efficient TNBC immunotherapy by dual reprogramming tumor-infiltrating dendritic cells and tumor-associated macrophages with stimulus-responsive miR155 nanocomplexes
In this study, pH/ROS-responsive microRNA-155 (miR155) nanocomplexes (MiR@PCPmP NPs) were developed to reprogram TIDCs and TAMs for efficient TNBC immunotherapy. This nanoplatform was based on a pH/ROS cleavable copolymer of poly(ethylene glycol)-carboxydimethyl maleate-poly(ethyleneimine)-peroxalate ester-poly(ε-caprolactone) grafted with mannose moieties (PEG-CDM-PEI[Man]-ox-PCL) which self-assembled with miRNA to form nanocomplexes. In the tumor microenvironment, the nanocomplexes showed selective cellular uptake by TIDCs and TAMs through PEG detachment and mannose exposure, followed by efficient endosomal escape, cyto...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenghui Jing Yanfeng Li Jinxiao Song Xinlong Zang Source Type: research
Comprehensive review on single and dual modification of starch: Methods, properties and applications
Int J Biol Macromol. 2023 Sep 16:126952. doi: 10.1016/j.ijbiomac.2023.126952. Online ahead of print.ABSTRACTStarch is a natural, renewable, affordable, and easily available polymer used as gelling agents, thickeners, binders, and potential raw materials in various food products. Due to these techno-functional properties of starch, food and non-food industries are showing interest in developing starch-based food products such as films, hydrogels, starch nanoparticles, and many more. However, the application of native starch is limited due to its shortcomings. To overcome these problems, modification of starch is necessary. ...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Bharati Kumari Nandan Sit Source Type: research
A new solid phase extraction sorbent developed based on cyanopropyl functionalized silica nanoparticles for organophosphorus pesticides determination
Environ Res. 2023 Sep 16:117167. doi: 10.1016/j.envres.2023.117167. Online ahead of print.ABSTRACTIn this work, a simple sol-gel approach was used for the preparation of cyanopropyl (CNPr) functionalized silica nanoparticles (SiO2-CNPr) that tetraethoxysilane (TEOS) and cyanopropyltriethoxysilane (CNPrTEOS) used as precursors. This as-prepared SiO2-CNPr nanoparticle sorbent was first characterized using FESEM, EDX, FTIR, TGA, and BET techniques. Then, the SiO2-CNPr nanoparticle was applied as a new SPE sorbent for determining trace levels of OPPs in environmental water samples. To enhance the simultaneous extraction of non...
Source: Environmental Research - September 18, 2023 Category: Environmental Health Authors: Zahra Sotoudehnia Korrani Elham Khalili Hesam Kamyab Wan Aini Wan Ibrahim Haslenda Hashim Source Type: research
Fe-NPs and Zn-NPs: Advancing Aquaculture Performance Through Nanotechnology
Biol Trace Elem Res. 2023 Sep 18. doi: 10.1007/s12011-023-03850-6. Online ahead of print.ABSTRACTAquaculture is a growing industry facing several challenges, including disease control, water quality management, and sustainable feed production. One potential solution to these challenges is the use of trace elements such as iron (Fe) and zinc (Zn), either in their conventional form or as nanoparticles (NPs). Aquatic animals need these micronutrients for normal growth, physiological processes, and overall health. In marine species, iron boosts development, immunity, and disease resistance. At the same time, zinc enhances meta...
Source: Biological Trace Element Research - September 18, 2023 Category: Biology Authors: Farkhanda Asad Navaira Batool Aiman Nadeem Shehar Bano Noshaba Anwar Rafia Jamal Shahbaz Ali Source Type: research
Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats?
Biol Trace Elem Res. 2023 Sep 18. doi: 10.1007/s12011-023-03842-6. Online ahead of print.ABSTRACTThe present study aims to investigate the ability of CaNa2EDTA (ethylenediaminetetraacetic acid) macroparticles and nanoparticles to treat cadmium-induced toxicity in female rats and to compare their efficacies. Forty rats were divided into 4 equal groups: control, cadmium, cadmium + CaNa2EDTA macroparticles and Cd + CaNa2EDTA nanoparticles. Cadmium was added to the drinking water in a concentration of 30 ppm for 10 weeks. CaNa2EDTA macroparticles and nanoparticles (50 mg/kg) were intraperitoneally injected during the last 4 we...
Source: Biological Trace Element Research - September 18, 2023 Category: Biology Authors: Safa M Saleh Osama S El-Tawil Manal B Mahmoud Sahar S Abd El-Rahman Eiman M El-Saied Peter A Noshy Source Type: research
Multi-level biological responses of Daphnia magna exposed to settleable atmospheric particulate matter from metallurgical industries
Aquat Toxicol. 2023 Sep 9;263:106692. doi: 10.1016/j.aquatox.2023.106692. Online ahead of print.ABSTRACTMetallurgical industries are a continuous source of air pollution due to the amount of settleable particulate matter (SePM) they release. This SePM is a complex mixture formed by metallic nanoparticles and metals, which reach terrestrial and aquatic ecosystems and can be a significant source of contamination. The aim of this study was to evaluate the adverse effects of SePM at different levels of biological organization in order to estimate its ecological impacts on aquatic ecosystems. For this purpose, the crustacean Da...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Mar ía Pilar González Andrea Cordero-de-Castro David Salvatierra Rajaa Kholssi Marisa Narciso Fernandes Juli án Blasco Cristiano V M Ara újo Camilo Dias Seabra Pereira Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Improvement and Regulation of Steviol Glycoside Biosynthesis in Stevia rebaudiana Bertoni
Gene. 2023 Sep 16:147809. doi: 10.1016/j.gene.2023.147809. Online ahead of print.ABSTRACTStevia rebaudiana Bertoni is a natural sweetener plant that is progressively used not only for its sweetening properties but also for its medicinal properties. The plant contains steviol glycoside (SG) which is reported to be up to 300 times sweeter than sucrose. The plant is said to have no side effects on human health and has been approved by FDA. On the basis of previous studies and available databases, this review discusses the extensive understanding of the different approaches for enhancements of SG in S. rebaudiana. To improve t...
Source: Gene - September 18, 2023 Category: Genetics & Stem Cells Authors: Pritom Biswas Ankita Kumari Arpan Modi Nitish Kumar Source Type: research
Gd/hafnium oxide@gold@chitosan core-shell nanoparticles as a platform for multimodal theranostics in oncology research
Chem Commun (Camb). 2023 Sep 18. doi: 10.1039/d3cc02971a. Online ahead of print.ABSTRACTIn the current study, we synthesized thiolated chitosan-stabilized gold-coated, gadolinium-doped hafnium oxide nanoparticles (CAuGH NPs) with the capability of acting as a multifunctional system to deliver anticancer drug doxorubicin (DOX), to enhance radiosensitization by ROS generation, and to provide magnetic resonance (MR) imaging contrast for biomedical applications.PMID:37721201 | DOI:10.1039/d3cc02971a
Source: Chemical Communications - September 18, 2023 Category: Chemistry Authors: Aastha Gupta Ritu Singhmar Ankur Sood Dimpy Bhardwaj S Senthil Kumaran Shubhra Chaturvedi Garima Agrawal Source Type: research
Rotenone nanoparticles based on mesoporous silica to improve the stability, translocation and insecticidal activity of rotenone
Environ Sci Pollut Res Int. 2023 Sep 19. doi: 10.1007/s11356-023-29842-6. Online ahead of print.ABSTRACTNanotechnology has been widely applied for pesticide carriers, which is an important way to improve the utilization, stability, and sustained release of pesticides. Mesoporous silica nanoparticles (MSNs) are a nanomaterial with adjustable particle and pore sizes, with a high specific surface area and good biocompatibility. Rotenone is a non-systemic botanical insecticide that is easily degraded in the environment. We used a modified soft-template method to prepare MSNs, in which rotenone was loaded using the solvent evap...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Wangjin Xu Dianjing Shen Xiaojun Chen Ming Zhao Tianle Fan Qinchao Wu Zhiyuan Meng Jiajia Cui Source Type: research
SERS-substrates based on ZnO nanoflowers prepared by green synthesis
Anal Biochem. 2023 Sep 16:115328. doi: 10.1016/j.ab.2023.115328. Online ahead of print.ABSTRACTZnO nanoparticles (NPs) with a flower-like morphology, synthesized by an affordable colloidal route using an aqueous fungi extract of Ganoderma lucidum as a reducing agent and stabilizer, are investigated as SERS-substrate. Each "flower" has large effective surface that is preserved at packing particles into a dense film and thus exhibits an advantageous property for SERS and similar sensing applications. The mycoextract used in our low-cost and green synthesis as surface stabilizer allows subsequent deposition of metal NPs or la...
Source: Analytical Biochemistry - September 18, 2023 Category: Biochemistry Authors: Volodymyr Dzhagan Oleksandr Smirnov Mariia Kovalenko Oleksandr Gudymenko Nazar Mazur Olga Kapush Mykola Skoryk Yaroslav Pirko Alla Yemets Mykhailo Valakh Petro Shepeliavyi Volodymyr Yukhymchuk Source Type: research
Spinel ferrite nanoparticles as potential materials in chlorophenol removal from wastewater
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29809-7. Online ahead of print.ABSTRACTPersistent organic pollutants (POPs) including chlorophenols (CPs) are increasing in water effluents, creating serious problems for both aquatic and terrestrial lives. Several research attempts have considered the removal of CPs by functionalised nanomaterials as adsorbents and catalysts. Besides the unique crystal structure, spinel ferrite nanomaterials (SFNs) own interesting optical and magnetic properties that give them the potential to be utilised in the removal of different types of CPs. In this review, we highlight...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Basma Al-Najar Ayman H Kamel Hanan Albuflasa Nicholas P Hankins Source Type: research
