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Functionalized fluorescent organic nanoparticles based AIE enabling effectively targeting cancer cell imaging
We report a fluorescent dye TM by incorporating the tetraphenylethylene (TPE) and cholesterol components into perylene bisimides (PBI) derivative. Fluorescence emission spectrum shows that the dye has stable red emission and aggregation-induced emission (AIE) characteristics. The incorporation of cholesterol components triggers TM to show induced chirality through supramolecular self-assembly. The cRGD-functionalized nanoparticles were prepared by encapsulating fluorescent dyes with amphiphilic polymer matrix. The functionalized fluorescent organic nanoparticles exhibit excellent biocompatibility, large Stokes' shift and g...
Source: Chembiochem - September 17, 2023 Category: Biochemistry Authors: Jing Zhang Jiaqi Liu Chengyan Niu Qiulan Wu Jingjing Tan Ning Jing Ying Wen Source Type: research
Application of lipid and polymeric-based nanoparticles for treatment of inner ear infections via XGBoost
Environ Res. 2023 Sep 15:117115. doi: 10.1016/j.envres.2023.117115. Online ahead of print.ABSTRACTTaking hearing loss as a prevalent sensory disorder, the restricted permeability of blood flow and the blood-labyrinth barrier in the inner ear pose significant challenges to transporting drugs to the inner ear tissues. The current options for hear loss consist of cochlear surgery, medication, and hearing devices. There are some restrictions to the conventional drug delivery methods to treat inner ear illnesses, however, different smart nanoparticles, including inorganic-based nanoparticles, have been presented to regulate dru...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Jie Zhang Chen Ru Shuainan Chen Die Yu Dalia H Elkamchouchi Mohammed S Alqahtani Hamid Assilzadeh Zhongguan Huang Yideng Huang Source Type: research
Nanoparticles-assisted aptamer biosensing for the detection of environmental pathogens
Environ Res. 2023 Sep 15:117123. doi: 10.1016/j.envres.2023.117123. Online ahead of print.ABSTRACTGiven the importance of public health, it is crucial to develop quick, targeted, highly sensitive, and accurate technologies to monitor pathogenic microbes in response to the growing concerns of food and environmental safety. Although conventional approaches for microbiological detection are available, they are laborious, and often skill demanding. Therefore, such approaches are incompetent in the on-site or high-throughput assessment of pathogenic microbes. Numerous efforts have been made to develop biosensors that use nuclei...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Kamal Rahimizadeh Qurat Ul Ain Zahra Suxiang Chen Bao T Le Ismat Ullah Rakesh N Veedu Source Type: research
Green synthesis of multifunctional zinc oxide nanoparticles from cordia myxa gum; and their catalytic reduction of nitrophenol, anticancer and antimicrobial activity
This study uses CMX gum as a bioreduction to produce multifunctional, environmentally friendly zinc-oxide nanocomposites (ZnO NPs). The process involves a low reaction time and temperature and utilizes CMX as a reducing and stabilizing agent. The structural, morphological, and optical properties of the CMX-ZnO nanocomposite were characterized. The biosynthetic CMX-ZnO NPs exhibited robust catalytic activity and recycling capacity for rapidly oxidizing hazardous p-NPs. The complete reduction of 4-NP to CMX-ZnO NPs in excess NaBH4 was achieved within 15 min, with recyclability and pseudo-first-order kinetics with a rate cons...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Kasula Nagaraja O H Tae Hwan Source Type: research
A new SERS quantitative analysis method for trace malathion with recognition and catalytic amplification difunctional MOF < sub > Tb < /sub > @Au@MIP nanoprobe
Talanta. 2023 Sep 13;267:125166. doi: 10.1016/j.talanta.2023.125166. Online ahead of print.ABSTRACTNew multifunctional nanomaterial preparation and its application to trace pollutant analysis are interesting to peoples. Using terbium metal-organic framework loaded gold nanoparticles (MOFTb@Au) as the nanosubstrate and 3-aminopropyltriethoxysilane (APTES) as the functional monomer, a new bifunctional nanosurface molecularly imprinted polymer nanoprobe of MOFTb@Au@MIP with strongly recognition and catalytic amplification functions was prepared by the microwave sol-gel procedure. It was characterized by scanning electron micr...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Yiyi Shu Jingjing Li Hongyan Bai Aihui Liang Guiqing Wen Zhiliang Jiang Source Type: research
Functionalized fluorescent organic nanoparticles based AIE enabling effectively targeting cancer cell imaging
We report a fluorescent dye TM by incorporating the tetraphenylethylene (TPE) and cholesterol components into perylene bisimides (PBI) derivative. Fluorescence emission spectrum shows that the dye has stable red emission and aggregation-induced emission (AIE) characteristics. The incorporation of cholesterol components triggers TM to show induced chirality through supramolecular self-assembly. The cRGD-functionalized nanoparticles were prepared by encapsulating fluorescent dyes with amphiphilic polymer matrix. The functionalized fluorescent organic nanoparticles exhibit excellent biocompatibility, large Stokes' shift and g...
Source: Chembiochem - September 17, 2023 Category: Biochemistry Authors: Jing Zhang Jiaqi Liu Chengyan Niu Qiulan Wu Jingjing Tan Ning Jing Ying Wen Source Type: research
Effervescent tablet-assisted deep eutectic solvent based on magnetic nanofluid for liquid phase microextraction of tyrosine kinase inhibitors in plasma samples by high-performance liquid chromatography
CONCLUSIONS: The developed method displayed high sensitivity, low consumption of solvent, low cost, simplicity, high recoveries, short extraction time, and good repeatability for determination of three anti-cancer drugs in human plasma samples.PMID:37717246 | DOI:10.1007/s43440-023-00524-x
Source: Pharmacological Reports - September 17, 2023 Category: Drugs & Pharmacology Authors: Khosrou Abdi Maryam Ezoddin Laleh Adlnasab Bahar Aziz Kabiri Mohammad Ali Karimi Somaye Behnamipour Houman Alimoradi Source Type: research
Fruit peel bioactives, valorisation into nanoparticles and potential applications: A review
Source: Critical Reviews in Food Science and Nutrition - September 17, 2023 Category: Nutrition Authors: Suhag, Rajat Kumar, Rohit Dhiman, Atul Sharma, Arun Prabhakar, Pramod K. Gopalakrishnan, Krishna Kumar, Ritesh Singh, Anurag Source Type: research
A novel bioactive postbiotics: from microbiota-derived extracellular nanoparticles to health promoting
Source: Critical Reviews in Food Science and Nutrition - September 17, 2023 Category: Nutrition Authors: Gu, Zelin Meng, Shuhan Wang, Yu Lyu, Bo Li, Pinglan Shang, Nan Source Type: research
Inside-Out Regulation of MnO toward Fast Reaction Kinetics in Aqueous Zinc Ion Batteries
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC03908K, CommunicationZixiang Cui, Jing Zhang, Shenfei Zhao, Ke Wu, Chunjie Li, Ruguang Ma, Changming Li An “inside-out regulation” strategy is proposed to improve the Zn2+ storage of MnO by Ni doping into the lattice and graphene wrap outside the nanoparticles. The as-prepared Ni-MnO@rGO exhibits112 mA... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 16, 2023 Category: Chemistry Authors: Zixiang Cui Source Type: research
The linkage between microRNA and cancer and its delivery as cancer therapy: A mini-review
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):7-18. doi: 10.14715/cmb/2023.69.7.2.ABSTRACTThe central dogma of molecular biology was no longer "central" after ground-breaking discoveries conveyed gene expression involves more complex physiological functions in cancer pathogenesis over the last decade. MicroRNAs (miRNAs) are short non-coding RNA that regulate gene expression, affecting key molecular pathways involved in sustaining the proliferative signalling for tumour development, evasion of cellular death, invasion, angiogenesis, as well as metastasis in a plethora of cancer types. MiRNA expression is dysregulated in...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Syed Umar Faruq Syed Najmuddin Ammar Akram Kamarudin Suraya Abdul Sani Mohd Nor Faiz Norrrahim Nur 'Atikah Abdul Latif Lucky Goh Poh Wah Source Type: research
Removal of an agricultural herbicide (2,4-Dichlorophenoxyacetic acid) using magnetic nanocomposite: A combined experimental and modeling studies
This study focused on modeling the removal of one of the widely used agricultural herbicides known as 2,4-Dichlorophenoxyacetic acid (2,4-D) using polypyrrole-coated Fe2O3 nanoparticles (Fe2O3@PPy). The Fe2O3@PPy nanocomposite was synthesized by surface-coating the Tabebuia aurea leaf extract synthesized Fe2O3 nanoparticles with polypyrrole. After characterization, the adsorptive potential of the nanocomposite for removing 2,4-D from aqueous solution was examined. Central composite design (CCD) was employed for optimizing the adsorption, revealing an adsorption efficiency of 90.65% at a 2,4-D concentration of 12 ppm, a dos...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Sridevi H Ramananda Bhat M Raja Selvaraj Source Type: research
Progress in the treatment of drug-loaded nanomaterials in renal cell carcinoma
This article reviews the use of nanomaterials, such as liposomes, polymeric nanoparticles, nanocomposites, carbon nanomaterials, nanobubbles, nanomicelles, and mesoporous silica nanoparticles, for RCC treatment, and discusses their advantages and disadvantages.PMID:37716114 | DOI:10.1016/j.biopha.2023.115444
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Jianyang Li Kunzhe Wu Jinmei Zhang Huan Gao Xiaohua Xu Source Type: research
Effects of polyvinylchloride microplastics on the toxicity of nanoparticles and antibiotics to aerobic granular sludge: Nitrogen removal, microbial community and resistance genes
Environ Res. 2023 Sep 14:117151. doi: 10.1016/j.envres.2023.117151. Online ahead of print.ABSTRACTCopper oxide nanoparticles (CuO NPs) and ciprofloxacin (CIP) have ecological risk to humans and ecosystems. Polyvinylchloride microplastics (PVC MPs), as a representative of microplastics, may often coexist with CuO NPs and CIP in wastewater treatment systems due to their widespread application. However, the co-impact of PVC MPs in wastewater systems contained with CuO NPs and CIP on nitrogen removal and ecological risk is not clear. In this work, PVC MPs co-impacts on the toxicity of CuO NPs and CIP to aerobic granular sludge...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Yu-Qi Li Bai-Hang Zhao Yu-Qing Zhang Xin-Yue Zhang Xiao-Tang Chen Hai-Shan Yang Source Type: research
The linkage between microRNA and cancer and its delivery as cancer therapy: A mini-review
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):7-18. doi: 10.14715/cmb/2023.69.7.2.ABSTRACTThe central dogma of molecular biology was no longer "central" after ground-breaking discoveries conveyed gene expression involves more complex physiological functions in cancer pathogenesis over the last decade. MicroRNAs (miRNAs) are short non-coding RNA that regulate gene expression, affecting key molecular pathways involved in sustaining the proliferative signalling for tumour development, evasion of cellular death, invasion, angiogenesis, as well as metastasis in a plethora of cancer types. MiRNA expression is dysregulated in...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Syed Umar Faruq Syed Najmuddin Ammar Akram Kamarudin Suraya Abdul Sani Mohd Nor Faiz Norrrahim Nur 'Atikah Abdul Latif Lucky Goh Poh Wah Source Type: research
