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Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | PMC:PMC10505582 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research

Storage stability of chocolate can be enhanced using locust protein-based film incorporated with E. purpurea flower extract-based nanoparticles
Ultrason Sonochem. 2023 Sep 7;100:106594. doi: 10.1016/j.ultsonch.2023.106594. Online ahead of print.ABSTRACTThe study aimed to develop a locust protein (Loct-Prot)-based film to enhance the lipid oxidative and storage stability of chocolate. The E. purpurea flower extract based-nanoparticles (EFNPs) were developed using ultrasonication (500 W and 20 kHz for 10 min) following a green method of synthesis. The EFPNs were incorporated at different levels [T0 (0%), T1 (1.0%), T2 (1.5%), and T3 (2.0%)] to impart bioactive properties to the Loct-Prot-based films which were used for packaging of white chocolate during 90 days tri...
Source: Ultrasonics Sonochemistry - September 15, 2023 Category: Chemistry Authors: Shubam Singh Hina F Bhat Sunil Kumar Rana Muhammad Aadil Maneesha S Mohan Charalampos Proestos Zuhaib F Bhat Source Type: research

RNA nanotechnology: A new chapter in targeted therapy
Colloids Surf B Biointerfaces. 2023 Sep 6;230:113533. doi: 10.1016/j.colsurfb.2023.113533. Online ahead of print.ABSTRACTNanoparticles have been widely studied in the fields of biotechnology, pharmacy, optics and medicine and have broad application prospects. Numerous studies have shown significant interest in utilizing nanoparticles for chemically coating or coupling drugs, aiming to address the challenges of drug delivery, including degradability and uncertainty. Furthermore, the utilization of lipid nanoparticles loaded with novel coronavirus antigen mRNA to control the COVID-19 pandemic has led to a notable surge in re...
Source: Colloids and Surfaces - September 15, 2023 Category: Biotechnology Authors: Tongtong Lv Yingying Meng Yifan Liu Yukun Han Hongwu Xin Xiaochun Peng Jinbai Huang Source Type: research

Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research

Curcumin-loaded chitosan nanoparticles alleviate fenpropathrin-induced hepatotoxicity by regulating lipogenesis and pyroptosis in rats
In this study, the probable alleviative role of curcumin (CMN) (50 mg/kg b.wt) or curcumin-loaded chitosan nanoparticle (CLC-NP) (50 mg/kg b.wt) was assessed against the hepatotoxic effect of a widely used pyrethroid insecticide, fenpropathrin (FEN) (15 mg/kg b.wt) in rats in a 60-day experiment. The results revealed that CMN and CLC-NP significantly suppressed the FEN-induced increment in serum hepatic enzyme activities (ALT, AST, ALP, and GGT) and hyperbilirubinemia. Moreover, FEN-associated dyslipidemia, hepatic oxidative stress, and altered hepatic histology were significantly rescued by CMN and CLC-NP. Furthermore, th...
Source: Food and Chemical Toxicology - September 15, 2023 Category: Food Science Authors: Leena S Alqahtani Yasmina M Abd-Elhakim Amany Abdel-Rahman Mohamed Norhan E Khalifa Tarek Khamis Badriyah S Alotaibi Manal Alosaimi Sanad S El-Kholy Samah S Abuzahrah Naira ElAshmouny Areej Adeeb Eskandrani Rasha A Gaber Source Type: research

Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research

Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | PMC:PMC10505582 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research

Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate: Different Aspects in Drug Delivery and Its Commercial Potential
AAPS PharmSciTech. 2023 Sep 15;24(7):188. doi: 10.1208/s12249-023-02645-1.ABSTRACTHydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are...
Source: AAPS PharmSciTech - September 15, 2023 Category: Drugs & Pharmacology Authors: Manisha Choudhari Shantanu Damle Ranendra Narayan Saha Sunil Kumar Dubey Gautam Singhvi Source Type: research

The Facile Synthesis of Eco-Friendly Zinc Magnesium Bimetal Nanoparticles and its Application in the Eradication of Xanthomonas oryzae pv. oryzae that Causes Leaf Blight Disease of Rice
Curr Microbiol. 2023 Sep 15;80(11):340. doi: 10.1007/s00284-023-03455-1.ABSTRACTIn this research work, we formulated and successfully assessed the antibacterial capability of zinc magnesium bimetal nanoparticles (ZnMgNPs) against Xanthomonas oryzae pv. oryzae (Xoo), the pathogenic microorganism responsible for causing the destructive leaf blight disease in rice. Successful preparation of ZnMgNPs were determined by UV-vis spectroscopy, EDX (Energy dispersive X-ray), FTIR (Fourier transform infrared) and SEM (Scanning Electron Microscopy). ZnMgNPs had antibacterial efficacy towards Xoo at MIC (minimum inhibitory concentratio...
Source: Current Microbiology - September 15, 2023 Category: Microbiology Authors: Kumari Vishakha Shatabdi Das Arnab Ganguli Source Type: research

Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | PMC:PMC10505582 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research

Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate: Different Aspects in Drug Delivery and Its Commercial Potential
AAPS PharmSciTech. 2023 Sep 15;24(7):188. doi: 10.1208/s12249-023-02645-1.ABSTRACTHydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are...
Source: AAPS PharmSciTech - September 15, 2023 Category: Drugs & Pharmacology Authors: Manisha Choudhari Shantanu Damle Ranendra Narayan Saha Sunil Kumar Dubey Gautam Singhvi Source Type: research

The Facile Synthesis of Eco-Friendly Zinc Magnesium Bimetal Nanoparticles and its Application in the Eradication of Xanthomonas oryzae pv. oryzae that Causes Leaf Blight Disease of Rice
Curr Microbiol. 2023 Sep 15;80(11):340. doi: 10.1007/s00284-023-03455-1.ABSTRACTIn this research work, we formulated and successfully assessed the antibacterial capability of zinc magnesium bimetal nanoparticles (ZnMgNPs) against Xanthomonas oryzae pv. oryzae (Xoo), the pathogenic microorganism responsible for causing the destructive leaf blight disease in rice. Successful preparation of ZnMgNPs were determined by UV-vis spectroscopy, EDX (Energy dispersive X-ray), FTIR (Fourier transform infrared) and SEM (Scanning Electron Microscopy). ZnMgNPs had antibacterial efficacy towards Xoo at MIC (minimum inhibitory concentratio...
Source: Current Microbiology - September 15, 2023 Category: Microbiology Authors: Kumari Vishakha Shatabdi Das Arnab Ganguli Source Type: research

Mycotoxins detection: view in the lens of molecularly imprinted polymer and nanoparticles
Source: Critical Reviews in Food Science and Nutrition - September 15, 2023 Category: Nutrition Authors: Mukunzi, Daniel Habimana, Jean de Dieu Li, Zhiyuan Zou, Xiaobo Source Type: research

Application of starch-based nanoparticles and cyclodextrin for prebiotics delivery and controlled glucose release in the human gut: a review
Source: Critical Reviews in Food Science and Nutrition - September 15, 2023 Category: Nutrition Authors: Liu, Yuwan Qiu, Chao Li, Xiaojing McClements, David Julian Wang, Chenxi Zhang, Zhiheng Jiao, Aiquan Long, Jie Zhu, Kunfu Wang, Jinpeng Jin, Zhengyu Source Type: research

Defects Healing of the ZnO Surface by Filling with Au Atom Catalysts for Efficient Photocatalytic H2 Production
In this study, surface oxygen vacancy (Vo) defects are created on ZnO (Vo-ZnO) NPs by directly pyrolyzing zeolitic imidazolate framework. The surface defects on Vo-ZnO provide active sites for the diffusion of single Au atoms and as nucleation sites for the formation of Au NPs by the in situ photodeposition process. The electronically healed surface defects by single Au atoms help in the formation of a heterojunction between the ZnO and plasmonic Au NPs. The formed Au/Vo-Au:ZnO-4 heterojunction prolongs photoelectron lifetimes and increases donor charge density. Therefore, the optimized photocatalysts of Au/Vo-Au:ZnO-4 has...
Source: Small - September 15, 2023 Category: Nanotechnology Authors: Santosh V. Mohite, Shinik Kim, Jiyoung Bae, Hee J. Jeong, Tae Woong Kim, Jihoon Choi, Yeonho Kim Tags: Research Article Source Type: research