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Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Storage stability of chocolate can be enhanced using locust protein-based film incorporated with E. purpurea flower extract-based nanoparticles
Ultrason Sonochem. 2023 Sep 7;100:106594. doi: 10.1016/j.ultsonch.2023.106594. Online ahead of print.ABSTRACTThe study aimed to develop a locust protein (Loct-Prot)-based film to enhance the lipid oxidative and storage stability of chocolate. The E. purpurea flower extract based-nanoparticles (EFNPs) were developed using ultrasonication (500 W and 20 kHz for 10 min) following a green method of synthesis. The EFPNs were incorporated at different levels [T0 (0%), T1 (1.0%), T2 (1.5%), and T3 (2.0%)] to impart bioactive properties to the Loct-Prot-based films which were used for packaging of white chocolate during 90 days tri...
Source: Ultrasonics Sonochemistry - September 15, 2023 Category: Chemistry Authors: Shubam Singh Hina F Bhat Sunil Kumar Rana Muhammad Aadil Maneesha S Mohan Charalampos Proestos Zuhaib F Bhat Source Type: research
Design, Development and in vitro quantification of novel electrosprayed Everolimus-loaded Soluplus ®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
In conclusion, the novel developed HPLC system can be applied for the quantification of different chemotherapeutic agents and the novel electrosprayed hydrogel NP is a potential drug delivery system to increase solubility and bioavailability of RAD001 in cancer therapy.PMID:37714413 | DOI:10.1016/j.ejpb.2023.09.008
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Lynn Louis Bor Shin Chee Marion McAfee Michael J D Nugent Source Type: research
Photoelectrocatalytic modification of nanofiltration membranes with SrF < sub > 2 < /sub > /Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > to simultaneously enhance heavy metal ions rejection and permeability
In this study, a water bath method was used to form SrF2/Ti3C2Tx (ST) nanoparticles on the surface of polyvinylidene fluoride (PVDF) membranes and an additional polyamide (PA) functional layer was formed at the interface by crosslinking. ST@PA composite NF membranes (STPP) with good photocatalytic performance were obtained. The separation and catalytic properties of the STPP membranes were controlled by the ST content, which modifies the surface structure and properties of the membranes. The membrane with optimal ST crosslinking exhibited a water contact angle of 50.8°, pure water flux of 24.6 L m-2·h-1·bar-1, and rejec...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Huiqi Zheng Xiaorong Meng Jiao Wu Danghao Liu Shanshan Huo Source Type: research
The Facile Synthesis of Eco-Friendly Zinc Magnesium Bimetal Nanoparticles and its Application in the Eradication of Xanthomonas oryzae pv. oryzae that Causes Leaf Blight Disease of Rice
Curr Microbiol. 2023 Sep 15;80(11):340. doi: 10.1007/s00284-023-03455-1.ABSTRACTIn this research work, we formulated and successfully assessed the antibacterial capability of zinc magnesium bimetal nanoparticles (ZnMgNPs) against Xanthomonas oryzae pv. oryzae (Xoo), the pathogenic microorganism responsible for causing the destructive leaf blight disease in rice. Successful preparation of ZnMgNPs were determined by UV-vis spectroscopy, EDX (Energy dispersive X-ray), FTIR (Fourier transform infrared) and SEM (Scanning Electron Microscopy). ZnMgNPs had antibacterial efficacy towards Xoo at MIC (minimum inhibitory concentratio...
Source: Current Microbiology - September 15, 2023 Category: Microbiology Authors: Kumari Vishakha Shatabdi Das Arnab Ganguli Source Type: research
Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate: Different Aspects in Drug Delivery and Its Commercial Potential
AAPS PharmSciTech. 2023 Sep 15;24(7):188. doi: 10.1208/s12249-023-02645-1.ABSTRACTHydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are...
Source: AAPS PharmSciTech - September 15, 2023 Category: Drugs & Pharmacology Authors: Manisha Choudhari Shantanu Damle Ranendra Narayan Saha Sunil Kumar Dubey Gautam Singhvi Source Type: research
Curcumin-loaded chitosan nanoparticles alleviate fenpropathrin-induced hepatotoxicity by regulating lipogenesis and pyroptosis in rats
In this study, the probable alleviative role of curcumin (CMN) (50 mg/kg b.wt) or curcumin-loaded chitosan nanoparticle (CLC-NP) (50 mg/kg b.wt) was assessed against the hepatotoxic effect of a widely used pyrethroid insecticide, fenpropathrin (FEN) (15 mg/kg b.wt) in rats in a 60-day experiment. The results revealed that CMN and CLC-NP significantly suppressed the FEN-induced increment in serum hepatic enzyme activities (ALT, AST, ALP, and GGT) and hyperbilirubinemia. Moreover, FEN-associated dyslipidemia, hepatic oxidative stress, and altered hepatic histology were significantly rescued by CMN and CLC-NP. Furthermore, th...
Source: Food and Chemical Toxicology - September 15, 2023 Category: Food Science Authors: Leena S Alqahtani Yasmina M Abd-Elhakim Amany Abdel-Rahman Mohamed Norhan E Khalifa Tarek Khamis Badriyah S Alotaibi Manal Alosaimi Sanad S El-Kholy Samah S Abuzahrah Naira ElAshmouny Areej Adeeb Eskandrani Rasha A Gaber Source Type: research
Lanthanum nanoparticle (La < sub > 2 < /sub > O < sub > 3 < /sub > )-loaded adsorbents for removal of hexavalent chromium: a kinetics, isotherm, and thermodynamic study
Environ Sci Pollut Res Int. 2023 Sep 16. doi: 10.1007/s11356-023-29834-6. Online ahead of print.ABSTRACTNanocomposite adsorbents for wastewater treatment gained popularity in recent times. In the present study, nanoparticles prepared from lanthanum have been loaded on the powdered form of aquatic plants Salvinia molesta (S. molesta) and Typha latifolia (T. latifolia). These new adsorbents were NPS (nanoparticle-loaded S. molesta) and NPT (nanoparticle-loaded T. latifolia). The batch study was carried out to assess the effect of several factors on the adsorption of Cr(VI) by novel adsorbents NPS and NPT. XRD, SEM, FTIR, EDX...
Source: Environmental Science and Pollution Research International - September 15, 2023 Category: Environmental Health Authors: Asha Singh Dinesh Arora Renu Bala Anil Khokhar Sunil Kumar Source Type: research
Glucosylated Hybrid TiO < sub > 2 < /sub > /Polymer Nanomaterials for Actively Targeted Sonodynamic Therapy of Cancer
Small. 2023 Sep 15:e2305475. doi: 10.1002/smll.202305475. Online ahead of print.ABSTRACTSonodynamic therapy (SDT) is an anti-cancer therapeutic strategy based on the generation of reactive oxygen species (ROS) upon local ultrasound (US) irradiation of sono-responsive molecules or nanomaterials that accumulate in the tumor. In this work, the sonodynamic efficiency of sono-responsive hybrid nanomaterials composed of amorphous titanium dioxide and an amphiphilic poly(ethylene oxide)-b-poly(propylene oxide) block copolymer is synthesized, fully characterized, and investigated both in vitro and in vivo. The modular and versatil...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ivan Zlotver Alejandro Sosnik Source Type: research
Albumin nanoparticles and their folate modified counterparts for delivery of a lupine derivative to hepatocellular carcinoma
In conclusion, functionalized nanoparticles (FA-PEG-CTr-NPs) can specifically inhibit the malignant proliferation of HCC cells and are thus a promising nanoagent for the treatment of HCC.PMID:37713994 | DOI:10.1016/j.biopha.2023.115485
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Haohao Wang Di Wu Pan Wang Chunyu Gao Hongbo Teng Dong Liu Yan Zhao Rui Du Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
ZIF-8 @polycarbonate nanocomposite membranes for improved permeability and selectivity for hydrogen gas
Environ Sci Pollut Res Int. 2023 Sep 15. doi: 10.1007/s11356-023-29650-y. Online ahead of print.ABSTRACTThrough this work, we are reporting high-performance ZIF-8 @polycarbonate nanocomposite membranes with satisfactory structural stability for improving the gas separation performance. ZIF-8 nanoparticles were synthesised using the wet chemical route with cubic morphology and controlled size using CTAB as a surfactant. The membranes were prepared using the solution casting method by adding ZIF-8 filler at various concentrations. The synthesised filler material and MMMs were characterised through X-ray diffraction spectrosc...
Source: Environmental Science and Pollution Research International - September 15, 2023 Category: Environmental Health Authors: Prashant Choudhary Nishel Saini Myung Han Yoon Kamlendra Awasthi Kamakshi Pandey Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
RNA nanotechnology: A new chapter in targeted therapy
Colloids Surf B Biointerfaces. 2023 Sep 6;230:113533. doi: 10.1016/j.colsurfb.2023.113533. Online ahead of print.ABSTRACTNanoparticles have been widely studied in the fields of biotechnology, pharmacy, optics and medicine and have broad application prospects. Numerous studies have shown significant interest in utilizing nanoparticles for chemically coating or coupling drugs, aiming to address the challenges of drug delivery, including degradability and uncertainty. Furthermore, the utilization of lipid nanoparticles loaded with novel coronavirus antigen mRNA to control the COVID-19 pandemic has led to a notable surge in re...
Source: Colloids and Surfaces - September 15, 2023 Category: Biotechnology Authors: Tongtong Lv Yingying Meng Yifan Liu Yukun Han Hongwu Xin Xiaochun Peng Jinbai Huang Source Type: research
Size, Surface Properties, and Ion Release of Zinc Oxide Nanoparticles: Effects on Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition in Neuronal PC-12 Cells
Biol Trace Elem Res. 2023 Sep 15. doi: 10.1007/s12011-023-03832-8. Online ahead of print.ABSTRACTThe extensive applications of zinc oxide nanoparticles (ZnO NPs) have resulted in a substantial risk of human exposure. However, the knowledge of the toxicity of these NPs in the nervous system is still limited. A comparative analysis of ZnO NPs of various sizes and NPs of the same size, with and without surface coating, and the potential role of released zinc ions is yet to be thoroughly explored. As a result, we have studied the cellular toxicity of two different-sized ZnO NPs, ZnO-22 (22 nm) and ZnO-43 (43 nm), and NPs with ...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Jitendra Kumar Suthar Anuradha Vaidya Selvan Ravindran Source Type: research
