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Challenges and Opportunities Associated With Drug Delivery for the Treatment of Solid Tumors
Oncol Rev. 2023 Aug 30;17:10577. doi: 10.3389/or.2023.10577. eCollection 2023.ABSTRACTIn this review, we discuss the effectiveness of drug delivery system based on metal nanoparticles, and also, describe the problems associated with their delivery to tumor cells. Throughout recent years, more reports have appeared in the literature that demonstrate promising results for the treatment of various types of cancer using metal-based nanoparticles. Due to their unique physical and chemical properties, metal nanoparticles are effectively being used for the delivery of drug to the tumor cells, for cancer diagnosis and treatment. T...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Teona Paresishvili Zurab Kakabadze Source Type: research
Photoelectrocatalytic modification of nanofiltration membranes with SrF < sub > 2 < /sub > /Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > to simultaneously enhance heavy metal ions rejection and permeability
In this study, a water bath method was used to form SrF2/Ti3C2Tx (ST) nanoparticles on the surface of polyvinylidene fluoride (PVDF) membranes and an additional polyamide (PA) functional layer was formed at the interface by crosslinking. ST@PA composite NF membranes (STPP) with good photocatalytic performance were obtained. The separation and catalytic properties of the STPP membranes were controlled by the ST content, which modifies the surface structure and properties of the membranes. The membrane with optimal ST crosslinking exhibited a water contact angle of 50.8°, pure water flux of 24.6 L m-2·h-1·bar-1, and rejec...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Huiqi Zheng Xiaorong Meng Jiao Wu Danghao Liu Shanshan Huo Source Type: research
Fabrication of Nickel/Zinc Oxide Nanocomposites from Citrus sinensis Extract Prompts Apoptosis Through Impeding JAK/STAT3 Signaling in Gastric Cancer
In this study, we sought to fabricate nickel/zinc oxide nanocomposites utilizing Citrus sinensis (C. sinensis) peel extract (CS-Ni/ZnO NCs) and investigate their ability to impede the JAK/STAT3 signaling pathway in gastric cancer AGS cells. Different methods, including UV-Vis spectral analysis, FT-IR, XRD, FE-SEM, EDAX, DLS, and zeta potential, were used to characterize the fabricated CS-Ni/ZnO NCs. By measuring ROS, MMP, and apoptotic cell death using the appropriate fluorescence describing procedures, the anticancer potential of CS-Ni/ZnO NCs was examined against AGS cells. The synthesized CS-Ni/ZnO NCs displayed a rod s...
Source: Applied Biochemistry and Biotechnology - September 15, 2023 Category: Biochemistry Authors: Zhifei Li Zhongwei Sun Source Type: research
Size, Surface Properties, and Ion Release of Zinc Oxide Nanoparticles: Effects on Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition in Neuronal PC-12 Cells
Biol Trace Elem Res. 2023 Sep 15. doi: 10.1007/s12011-023-03832-8. Online ahead of print.ABSTRACTThe extensive applications of zinc oxide nanoparticles (ZnO NPs) have resulted in a substantial risk of human exposure. However, the knowledge of the toxicity of these NPs in the nervous system is still limited. A comparative analysis of ZnO NPs of various sizes and NPs of the same size, with and without surface coating, and the potential role of released zinc ions is yet to be thoroughly explored. As a result, we have studied the cellular toxicity of two different-sized ZnO NPs, ZnO-22 (22 nm) and ZnO-43 (43 nm), and NPs with ...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Jitendra Kumar Suthar Anuradha Vaidya Selvan Ravindran Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
An appraisal of the utilization of natural gums as corrosion inhibitors: Prospects, challenges, and future perspectives
Int J Biol Macromol. 2023 Sep 13:126904. doi: 10.1016/j.ijbiomac.2023.126904. Online ahead of print.ABSTRACTNatural gums are macro compounds containing monosaccharide (sugar) units bonded by glycosidic to form long polymeric sugar chains of considerably high molecular weight. Natural gums are multifaceted in applications with the main areas being the food and pharmaceutical industries. The recent research interest in corrosion inhibitors is considering natural gums because of their abundance and ecological compatibility. Hence, this review takes a look at the use of natural gums in pure and modified forms in metals protect...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Ukeme J Timothy Peace S Umoren Moses M Solomon Isaac O Igwe Saviour A Umoren Source Type: research
Bacterial cellulose composite hydrogel for pre-concentration and mass spectrometric detection of thiol-containing biomarker
Int J Biol Macromol. 2023 Sep 13:126855. doi: 10.1016/j.ijbiomac.2023.126855. Online ahead of print.ABSTRACTSimple soaking of bacterial cellulose (BC) membrane in carboxymethyl cellulose (CMC) solution yielded BC/CMC hydrogel having re-swellable property. Then, gold nanoparticles (AuNPs) were embedded in the BC/CMC hydrogel via in situ chemical reduction to form BC/CMC/AuNPs composite hydrogel. It was found that the composite hydrogel exhibited physical/chemical characteristics similar to those of BC. The AuNPs with an average diameter of 13 nm distributed uniformly within the BC/CMC matrix as verified by transmission elec...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Panlop Lormaneenopparat Jutiporn Yukird Nadnudda Rodthongkum Voravee P Hoven Source Type: research
An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review
This article provides an update on using carbohydrate-based GNPs in liver cancer treatment, imaging, and drug administration. Selective surface modification of several carbohydrate types and further biological uses of GNPs are focused on.PMID:37714232 | DOI:10.1016/j.ijbiomac.2023.126889
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Abdullah R Alzahrani Ibrahim Abdel Aziz Ibrahim Naiyer Shahzad Imran Shahid Ibrahim M Alanazi Alaa Hisham Falemban Mohd Fahami Nur Azlina Source Type: research
Cobalt oxide-chitosan based nanocomposites: Synthesis, characterization and their potential pharmaceutical applications
Int J Biol Macromol. 2023 Sep 13:126856. doi: 10.1016/j.ijbiomac.2023.126856. Online ahead of print.ABSTRACTThis research aimed to prepare, characterize, and investigate the biological efficacy of chitosan‑cobalt (II) oxide hybrid nanocomposites against a variety of micrograms. Analytical methods, FTIR, SEM, XRD, and EDX, were utilized to thoroughly characterize the produced CS-CoO nanocomposite. In FTIR spectra, the presence of the chitosan peaks in addition to that of CoO at 681 and 558 cm-1 confirmed that CoO molecules interact with the chitosan backbone. Moreover, in the XRD measurements, significantly less chitosan ...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Ali H Bashal Khaled D Khalil Ahmed M Abu-Dief Mohamed A El-Atawy Source Type: research
Size, Surface Properties, and Ion Release of Zinc Oxide Nanoparticles: Effects on Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition in Neuronal PC-12 Cells
Biol Trace Elem Res. 2023 Sep 15. doi: 10.1007/s12011-023-03832-8. Online ahead of print.ABSTRACTThe extensive applications of zinc oxide nanoparticles (ZnO NPs) have resulted in a substantial risk of human exposure. However, the knowledge of the toxicity of these NPs in the nervous system is still limited. A comparative analysis of ZnO NPs of various sizes and NPs of the same size, with and without surface coating, and the potential role of released zinc ions is yet to be thoroughly explored. As a result, we have studied the cellular toxicity of two different-sized ZnO NPs, ZnO-22 (22 nm) and ZnO-43 (43 nm), and NPs with ...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Jitendra Kumar Suthar Anuradha Vaidya Selvan Ravindran Source Type: research
Evaluation of the Therapeutic Effect of Curcumin-Conjugated Zinc Oxide Nanoparticles on Reserpine-Induced Depression in Wistar Rats
In conclusion, curcumin-conjugated zinc oxide nanoparticles demonstrate potent antidepressant effects, alleviating depressive-like behavior in rats. These findings support Zn(cur)O NPs as a promising therapeutic strategy for depression management, warranting further investigation and clinical validation.PMID:37713054 | DOI:10.1007/s12011-023-03849-z
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Heba M Fahmy Fatmaalzahraa A Aboalasaad Ayman S Mohamed Fathi A Elhusseiny Yasser A Khadrawy Ahmed Elmekawy Source Type: research
Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy
Environ Res. 2023 Sep 13:117132. doi: 10.1016/j.envres.2023.117132. Online ahead of print.ABSTRACTM13 phages possessing filamentous phage genomes offer the benefits of selective display of molecular moieties and delivery of therapeutic agent payloads with a tolerable safety profile. M13 phage-displayed technology for resembling antigen portions led to the discovery of mimetic epitopes that applied to antibody-based therapy and could be useful in the design of anticancer vaccines. To date, the excremental experiences have engaged the M13 phage in the development of innovative biosensors for detecting biospecies, biomolecule...
Source: Environmental Research - September 15, 2023 Category: Environmental Health Authors: Mahmood Fadaie Hassan Dianat-Moghadam Elham Ghafouri Shamsi Naderi Mohammad Hossein Darvishali Mahsa Ghovvati Hossein Khanahmad Maryam Boshtam Pooyan Makvandi Source Type: research
Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research
Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of < em > Dabie bandavirus < /em > in aged ferrets
This study demonstrates that DBV GnH-FT nanoparticles provide an efficient vaccine efficacy in mouse and aged ferret models and should be an outstanding vaccine candidate targeted for the aged population against fatal DBV infection. IMPORTANCE Dabie bandavirus (DBV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS) in infected patients. Human SFTS symptoms progress from fever, fatigue, and muscle pain to the depletion of white blood cells and platelets with fatality rates up to 30%. The recent spread of its vector tick to over 20 states in the United States increases the potenti...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Dokyun Kim Eunha Kim Semi Kim Youseung Chung Chih-Jen Lai Inho Cha Sung-Dong Cho Yunseo Choi Xinghong Dai Stephanie Kim Seokmin Kang Mi-Jeong Kwak Ziyi Liu Younho Choi Su-Hyung Park Young Ki Choi Jae U Jung Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
