This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 1132 results found since Jan 2013.

Role and interest of hepcidin in iron homeostasis
Ann Biol Clin (Paris). 2023 May 16;81(2):111-124. doi: 10.1684/abc.2023.1805.ABSTRACTIron is an essential element to the well functionning of the organism and requires careful maintenance of its homeostasis. This is mainly due to hepcidin, a hormone secreted by the liver that controls the flow of iron within the body. It has a hyposideremic action by reducing the expression of ferroportin, the only protein known to this day, which can export iron into the extracellular environment. This has the effect of decreasing intestinal absorption and increasing intracellular retention, especially in macrophages. Hepcidin is stimulat...
Source: Annales de Biologie Clinique - May 15, 2023 Category: Biochemistry Authors: Julien Miozzo C écile Meunier Sophie Park Patrice Faure Laetitia Van Noolen Source Type: research

Ferroportin inhibitor vamifeport ameliorates ineffective erythropoiesis in a mouse model of β-thalassemia with blood transfusions
Haematologica. 2023 May 11. doi: 10.3324/haematol.2022.282328. Online ahead of print.ABSTRACTβ-thalassemia is an inherited anemia characterized by ineffective erythropoiesis. Blood transfusions are required for survival in transfusion-dependent β-thalassemia and are also occasionally needed in patients with non-transfusion-dependent β-thalassemia. Patients with transfusion-dependent β-thalassemia often have elevated transferrin saturation (TSAT) and non-transferrin-bound iron (NTBI) levels, which can lead to organ iron overload, oxidative stress, and vascular damage. Vamifeport is an oral ferroportin inhibitor that was...
Source: Haematologica - May 11, 2023 Category: Hematology Authors: Natarajaswamy Kalleda Anna Flace Patrick Altermatt Giada Ingoglia C édric Doucerain Naja Nyffenegger Franz D ürrenberger Vania Manolova Source Type: research

Expression of genes related to iron homeostasis in breast cancer
CONCLUSIONS: Our study portrayed the important association between genes involved in iron hemostasis and breast malignancy. The results could be used to establish new diagnostic techniques in the management of breast malignancies. The alterations in the metabolism of malignant breast cells with normal breast cells could be utilized to achieve advantages in treatment.PMID:37119411 | DOI:10.1007/s11033-023-08433-1
Source: Molecular Biology Reports - April 29, 2023 Category: Molecular Biology Authors: Tuba Mutlu Emre Ozoran Didem Can Trabulus Canan Kelten Talu Duygu Erhan Meltem Mete Mehmet Guven Source Type: research