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Total 1132 results found since Jan 2013.
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats
Biol Pharm Bull. 2022;45(9):1269-1275. doi: 10.1248/bpb.b22-00186.ABSTRACTEdaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury (CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate the anti-CIRI mechanism of edaravone based on the nuclear factor-E2-related factor 2 (Nrf2)/ferroportin (FPN) pathway that regulates ferroptosis-mediated cerebral ischemia-reperfusion injury. We evaluated the brain injury by constructing a middle cerebral artery occlusion and reperfusion (MCAO/R) model in rats. The results showed that cerebral infarct volume and neuro...
Source: Biological and Pharmaceutical Bulletin - September 1, 2022 Category: Drugs & Pharmacology Authors: Wenpeng Liu Linlin Wang Canwen Liu Ziwei Dai Tenglong Li Biao Tang Source Type: research
Self-recovery study of fluoride-induced ferroptosis in the liver of zebrafish (Danio rerio)
In this study, adult zebrafish and embryos were exposed to 0, 20, 40, 80 mg/L of fluoride for 30, 60 and 90 d and 3, 4 and 5 d post-fertilization (dpf), respectively. After 90 d, adult zebrafish were transferred to clean water for self-recovery of 30 d. The results showed that fluoride induced the prominent histopathologial changes in liver of adults, and the developmental delay and dark liver area in larvae. Fluoride significantly increased the iron overload, while decreased the expression levels of transferrin (tf), transferrin receptor (tfr), ferroportin (fpn), membrane iron transporter (fpn), and ferritin heavy chain (...
Source: Aquatic Toxicology - August 25, 2022 Category: Toxicology Authors: Yijie Wu Xiuling Zhang Jianjie Chen Jinling Cao Cuiping Feng Yongju Luo Yong Lin Source Type: research
Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation
Biometals. 2022 Aug 20. doi: 10.1007/s10534-022-00435-z. Online ahead of print.ABSTRACTHepcidin (HAMP), an iron regulatory hormone synthesized by liver hepatocytes, works together with ferritin (FTH) and ferroportin (FPN) in regulating the storage, transport, and utilization of iron in the cell. Epigenetic mechanisms, especially acetylation, also play an important role in the regulation of iron metabolism. However, a target protein has not been mentioned yet. With this preliminary study, we investigated the effect of histone acetyltransferase TIP60 on the expression of HAMP, FTH, and FPN. In addition, how the depletion of ...
Source: Biometals - August 20, 2022 Category: Biochemistry Authors: Nurdan G önül Baltacı Emine Toraman Mesut Aky üz Şeyda Nur Kalın Harun Budak Source Type: research
Roots of < em > Astragalus propinquus < /em > Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury
CONCLUSION: RAP stimulation inhibited ferroptosis by regulating the expression of the key ferroptosis factors XCT, SLC3A2, GPX4, NRF2, HO-1, and IREB2. In conclusion, RAP regulates transmembrane iron transport and ferroptosis to improve CIRI.PMID:35958925 | PMC:PMC9363172 | DOI:10.1155/2022/7410865
Source: Evidence-based Complementary and Alternative Medicine - August 12, 2022 Category: Complementary Medicine Authors: Juan Chen Donglai Ma Jun Bao Ying Zhang Guoxing Deng Source Type: research
Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer
CONCLUSION: The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.PMID:35921382 | DOI:10.1371/journal.pone.0272308
Source: Cancer Control - August 3, 2022 Category: Cancer & Oncology Authors: Fahmy T Ali Reham M Soliman Nahla S Hassan Ahmed M Ibrahim Mayada M El-Gizawy Abd Allah Y Mandoh Ehab A Ibrahim Source Type: research
Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
Cell Death & Disease, Published online: 01 August 2022; doi:10.1038/s41419-022-05043-wAstrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
Source: Cell death and disease - August 1, 2022 Category: Internal Medicine Authors: Linhao You Pan-Pan Yu Tianyu Dong Wenhuan Guo Shiyang Chang Bingjie Zheng Yunzhe Ci Fudi Wang Peng Yu Guofen Gao Yan-Zhong Chang Source Type: research
Hepcidin and Iron in Health and Disease
Annu Rev Med. 2022 Jul 29. doi: 10.1146/annurev-med-043021-032816. Online ahead of print.ABSTRACTHepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores. Hepcidin concentration in plasma is increased by iron loading and inflammation and is suppressed by erythropoietic stimulation and during pregnancy. Hepcidin deficiency causes iron overload in hemochromatosis and anemias with i...
Source: Annual Review of Medicine - July 29, 2022 Category: General Medicine Authors: Elizabeta Nemeth Tomas Ganz Source Type: research
