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Total 1132 results found since Jan 2013.

Comparative analysis of the functional properties of human and mouse ferroportin
We examined the functional properties of human Fpn, mouse Fpn, and mutant mouse Fpn by using radiotracer assays in RNA-injected Xenopus oocytes. We found that neither mouse nor human Fpn transports manganese. Mouse and human Fpn share identical properties with respect to substrate profile, calcium dependence, optimal pH, and hepcidin sensitivity. We have also demonstrated that Fpn is not an ATPase pump. Our findings validate the use of mouse models of ferroportin function in iron homeostasis and disease.PMID:36939203 | DOI:10.1152/ajpcell.00063.2023
Source: Am J Physiol Cell Ph... - March 20, 2023 Category: Cytology Authors: Corbin R Azucenas T Alex Ruwe John P Bonamer Bo Qiao Tomas Ganz Mika Jormakka Elizabeta Nemeth Bryan Mackenzie Source Type: research

Iron-loaded Extracellular Vesicles: Angel or Demon?
Free Radic Res. 2023 Mar 16:1-17. doi: 10.1080/10715762.2023.2191813. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are identified as a non-classical way to mediate iron efflux except ferroportin. Interestingly, recent studies indicated that EVs pathway is a novel way involved in iron efflux. Mitochondria-derived vesicles (MDVs) are the potential mediator to load mitochondrial iron into EVs. Additionally, iron-replete cells resist excess iron-induced damage by secreting iron-loaded EVs, and the uptake of these EVs induces oxidative damage in the recipient cell. Importantly, iron-loaded EVs play a key role in a...
Source: Free Radical Research - March 17, 2023 Category: Research Authors: Huimin Chen Yuhan Tang Source Type: research

A Novel Hepcidin Mutation
CONCLUSION: A novel hepcidin mutation was detected in a patient with massive iron overload, fatigue and hypogonadotropic hypogonadism.PMID:36925058 | DOI:10.1016/j.tracli.2023.03.001
Source: Transfusion Clinique et Biologique - March 16, 2023 Category: Hematology Authors: Louis Praeger-Jahnsen Karin Magnussen Frank Vinholt Schi ødt Rikke Christina Therkildsen Niels J ørgensen Lennart Friis-Hansen Source Type: research