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Total 1132 results found since Jan 2013.

Hyperferritinemia and non-HFE hemochromatosis: differential diagnosis and workup
Acta Gastroenterol Belg. 2023 Apr-Jun;86(2):356-359. doi: 10.51821/86.2.11249.ABSTRACTHyperferritinemia is a common reason for referral to a hepatogastroenterologist. The most frequent causes are not associated with iron overload (e.g. inflammatory diseases, alcohol abuse, metabolic syndrome, etc.). However, hyperferritinemia can also be caused by a genetic variant in one of the iron regulatory genes, called hereditary hemochromatosis, often but not always associated with iron overload. A variation in the human Hemostatic Iron Regulator protein (HFE) gene is the most common genotype, but many other variants have been descr...
Source: Acta Gastro-Enterologica Belgica - July 10, 2023 Category: Gastroenterology Authors: E Lommaert W Verlinden I Duysburgh T Holvoet J Schouten Source Type: research

Iron overload due to SLC40A1 mutation of type 4 hereditary hemochromatosis
Med Mol Morphol. 2023 Jun 29. doi: 10.1007/s00795-023-00359-8. Online ahead of print.ABSTRACTHereditary hemochromatosis type 4 is an autosomal-dominant inherited disease characterized by a mutation in the SLC40A1 gene encoding ferroportin. This condition can be further subdivided into types 4A (loss-of-function mutations) and 4B (gain-of-function mutations). To date, only a few cases of type 4B cases have been reported, and the treatment has not been clearly mentioned. Here, we report a genotype of hereditary hemochromatosis type 4B involving the heterozygous mutation c.997 T > C (p. Tyr333His) in SLC40A1. The patient w...
Source: Molecular Medicine - June 29, 2023 Category: Molecular Biology Authors: Jing Hu Yuan Li Li Zhang Guangxin Peng Fengkui Zhang Xin Zhao Source Type: research

Autophagy fuels mitochondrial function through regulation of iron metabolism in pancreatic cancer
Autophagy. 2023 Jun 13:1-2. doi: 10.1080/15548627.2023.2223473. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of any cancer in the United States. Our previous work has shown that autophagy can promote PDAC progression. We recently established the importance of autophagy in regulating bioavailable iron to control mitochondrial metabolism in PDAC. We found that inhibition of autophagy in PDAC leads to mitochondrial dysfunction due to abrogation of succinate dehydrogenase complex iron sulfur subunit B (SDHB) expression. Additionally, we observed that cancer-a...
Source: Autophagy - June 14, 2023 Category: Cytology Authors: Subhadip Mukhopadhyay Joel Encarnacion-Rosado Alec C Kimmelman Source Type: research

2D MoS2 Nanosheets Induce Ferroptosis by Promoting NCOA4 ‐Dependent Ferritinophagy and Inhibiting Ferroportin (Small 24/2023)
2D MoS2 NanosheetsMoS2 nanosheets accumulate Fe2+ in lysosomes by promoting NCOA4-dependent ferritinophagy. Fe2+ leaks from the damaged lysosomes into the cytoplasm, resulting in ferroptosis. This has important implications for elucidating the toxicity of 2D nanoparticles and determining their medical applications. More details can be found in article number2208063 by Wei Jiang and co-workers.
Source: Small - June 14, 2023 Category: Nanotechnology Authors: Bingyan Liu, Wei Jiang, Yiyuan Ye, Ling Liu, Xiaoran Wei, Qiu Zhang, Baoshan Xing Tags: Frontispiece Source Type: research

Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation
Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood –brain barrier. Apo-Tf indicates an iron-deficient environment a...
Source: Journal of Biomedical Science - June 6, 2023 Category: Biomedical Science Authors: Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson and James R. Connor Tags: Research Source Type: research

Ferroportin1 in the Brain
Ageing Res Rev. 2023 May 24:101961. doi: 10.1016/j.arr.2023.101961. Online ahead of print.ABSTRACTDespite years of research, it remains unclear why certain brain regions of patients with neurodegenerative diseases (NDs) have abnormally high levels of iron, although it has long been suggested that disrupted expression of iron-metabolizing proteins due to genetic or non-genetic factors is responsible for the enhancement in brain iron contents. In addition to the increased expression of cell-iron importers lactoferrin (lactotransferrin) receptor (LfR) in Parkinson's disease (PD) and melanotransferrin (p97) in Alzheimer's dise...
Source: Ageing Research Reviews - May 26, 2023 Category: Genetics & Stem Cells Authors: Zhong-Ming Qian Wei Li Qian Guo Source Type: research

Role and interest of hepcidin in iron homeostasis
Ann Biol Clin (Paris). 2023 Apr 1;81(2):111-124. doi: 10.1684/abc.2023.1805.ABSTRACTIron is an essential element to the well functionning of the organism and requires careful maintenance of its homeostasis. This is mainly due to hepcidin, a hormone secreted by the liver that controls the flow of iron within the body. It has a hyposideremic action by reducing the expression of ferroportin, the only protein known to this day, which can export iron into the extracellular environment. This has the effect of decreasing intestinal absorption and increasing intracellular retention, especially in macrophages. Hepcidin is stimulate...
Source: Annales de Biologie Clinique - May 15, 2023 Category: Biochemistry Authors: Julien Miozzo C écile Meunier Sophie Park Patrice Faure Laetitia Van Noolen Source Type: research