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Total 1132 results found since Jan 2013.

2D MoS2 Nanosheets Induce Ferroptosis by Promoting NCOA4 ‐Dependent Ferritinophagy and Inhibiting Ferroportin
This study reports that MoS2 nanosheets induces ferroptosis in vivo and in vitro, which is caused by the nanosheet themselves rather than by the dissolved ions. MoS2 nanosheets induce ferroptosis in epithelial (BEAS-2B) and macrophage (RAW264.7) cells due to nuclear receptor coactivator 4 (NCOA4)-dependent excusive ferritinophagy and the inhibition of ferroportin-1 (FPN). In this process, most of the MoS2 nanosheets enter the cells via macropinocytosis and are localized to the lysosome, contributing to an increase in the lysosomal membrane permeability. At the same time, NCOA4-dependent ferritinophagy is activated, and fer...
Source: Small - March 13, 2023 Category: Nanotechnology Authors: Bingyan Liu, Wei Jiang, Yiyuan Ye, Ling Liu, Xiaoran Wei, Qiu Zhang, Baoshan Xing Tags: Research Article Source Type: research

Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
In this study, we further demonstrated the effect of IONs on inhibiting the growth of diffuse large B-cell lymphoma (DLBCL) cells by enhancing ferroptosis-mediated cell death. IONs treatment caused an accumulation of intracellular ferrous iron and the onset of lipid peroxidation in DLBCL cells as well as the suppressed expression of anti-ferroptosis protein Glutathione Peroxidase 4 (GPX4), thereby leading to increased ferroptosis. Mechanistically, IONs increased cellular lipid peroxidation through the generation of ROS via the Fenton reaction and regulating the iron metabolism-related proteins, such as ferroportin (FPN) an...
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Qi-Tang Huang Quan-Quan Hu Zhao-Feng Wen Yan-Li Li Source Type: research

CDGSH iron sulfur domain 2 over ‐expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice
Ferroptosis has been implicated in the pathogenesis of secondary brain injury following intracerebral hemorrhage (ICH). A previous study showed that CDGSH iron sulfur domain 2 (CISD2) can inhibit ferroptosis. Thus, we investigated the effects ofCISD2 on ferroptosis and the mechanisms underlying its neuroprotective role in mice after ICH. The novel findings of the present study were:CISD2 was remarkably increased at 24  h after ICH and was mainly expressed in neurons.CISD2 over-expression ameliorated neurobehavioral deficits, brain edema, neuronal degeneration, and neuronal ferroptosis after ICH andCISD2 knockdown has the...
Source: Journal of Neurochemistry - March 8, 2023 Category: Neuroscience Authors: Ruihao Li, Xingyu Zhang, Lingui Gu, Ye Yuan, Xu Luo, Weiwei Shen, Zongyi Xie Tags: ORIGINAL ARTICLE Source Type: research

Downregulation of hepcidin by norcantharidin in macrophage
Nat Prod Res. 2023 Feb 28:1-6. doi: 10.1080/14786419.2023.2185236. Online ahead of print.ABSTRACTNorcantharidin (NCTD) is a demethylated analogue of cantharidin. It was recently demonstrated that NCTD reduces iron contents in the liver and spleen of mice in vivo, indicating that NCTD can affect iron metabolism via hepcidin. Here, we investigated the effects of NCTD on expression of iron storage protein ferritin-light chain (Ft-L), transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferroportin 1 (Fpn1), hepcidin, iron regulatory protein 1 (IRP1), IL-6, p-JAK2 and p-STAT3 in lipopolysaccharides (LPS)-treated...
Source: Natural Product Research - March 1, 2023 Category: Biochemistry Authors: Jie Zheng Zhong-Ming Qian Yu-Xin Sun Yu-Xin Bao Source Type: research

Studying ferroptosis and iron metabolism pre- and post-radiotherapy treatment in breast cancer patients
CONCLUSION: Radiotherapy induced ferroptosis in breast cancer patients as a new cell death mechanism and PTGS2 is a biomarker of ferroptosis. Iron modulation is a useful approach for the treatment of BC especially if combined with targeted therapy and immune-based therapy. Further studies are warranted to be translated into clinical compounds.PMID:36847926 | DOI:10.1186/s43046-023-00162-7
Source: J Egypt Natl Canc In... - February 27, 2023 Category: Cancer & Oncology Authors: Sanaa A El-Benhawy Ibrahim G Abdelrhman Nadia A Sadek Enayat I Fahmy Ahmed A AboGabal Hossam Elmasry Sally A M Saleh Ola A Sakr Mona Nagy Elwany Maha Abubakr Feissal Rabie Source Type: research

Comparative study on antibacterial characteristics of the multiple liver expressed antimicrobial peptides (LEAPs) in teleost fish
In this study, LEAP-2C from rainbow trout and grass carp were discovered, both of which are composed of 3 exons and 2 introns. The antibacterial functions of the multiple LEAPs were systematically compared in rainbow trout and grass carp. The gene expression pattern revealed that rainbow trout and grass carp LEAP-1, LEAP-2A, LEAP-2B and/or LEAP-2C were differentially expressed in various tissues/organs, mainly in liver. After bacterial infection, the expression levels of LEAP-1, LEAP-2A, LEAP-2B and/or LEAP-2C in the liver and gut of rainbow trout and grass carp increased to varying degrees. Moreover, the antibacterial ass...
Source: Frontiers in Immunology - February 20, 2023 Category: Allergy & Immunology Source Type: research

CDGSH iron sulfur domain 2 overexpression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice
AbstractFerroptosis has been implicated in the pathogenesis of secondary brain injury following intracerebral hemorrhage (ICH), and regulating this process is considered a potential therapy for alleviating further brain injury. A previous study showed that CDGSH iron sulfur domain 2 (CISD2) can inhibit ferroptosis in cancer. Thus, we investigated the effects ofCISD2 on ferroptosis and the mechanisms underlying its neuroprotective role in mice after ICH.CISD2 expression markedly increased after ICH.CISD2 overexpression significantly decreased the number of Fluoro-Jade C-positive neurons and alleviated brain edema and neurob...
Source: Journal of Neurochemistry - February 18, 2023 Category: Neuroscience Authors: Ruihao Li, Xingyu Zhang, Lingui Gu, Ye Yuan, Xu Luo, Weiwei Shen, Zongyi Xie Tags: ORIGINAL ARTICLE Source Type: research

Protective Effect of Sevoflurane Preconditioning on Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Modulating Iron Homeostasis and Ferroptosis
In conclusion, Sev relieves H/R-induced cardiomyocyte injury by regulating iron homeostasis and ferroptosis.PMID:36800141 | DOI:10.1007/s12012-023-09782-w
Source: Cardiovascular Toxicology - February 17, 2023 Category: Cardiology Authors: Hongguang Sheng Jun Xiong Danying Yang Source Type: research