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Total 1132 results found since Jan 2013.
Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects
J Mol Med (Berl). 2022 Oct 10. doi: 10.1007/s00109-022-02254-8. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is one of the most common chronic liver diseases. Its pathological spectrum includes the overlapping stages of hepatic steatosis/steatohepatitis that can progress to liver fibrosis and cirrhosis; both are risk factors for hepatocellular carcinoma. Moreover, ALD diagnosis and management pose several challenges. The early pathological stages are reversible by alcohol abstinence, but these early stages are often asymptomatic, and currently, there is no specific laboratory biomarker or diagnostic...
Source: Molecular Medicine - October 10, 2022 Category: Molecular Biology Authors: Kevin Ferrao Najma Ali Kosha J Mehta Source Type: research
SARS-CoV-2-induced hypomethylation of the ferritin heavy chain (FTH1) gene underlies serum hyperferritinemia in severe COVID-19 patients
Biochem Biophys Res Commun. 2022 Sep 25;631:138-145. doi: 10.1016/j.bbrc.2022.09.083. Online ahead of print.ABSTRACTHigh serum ferritin (hyperferritinemia), a reliable hallmark of severe COVID-19 often associates with a moderate decrease in serum iron (hypoferremia) and a moderate increase in serum hepcidin. This suggests that hyperferritinemia in severe COVID-19 is reflective of inflammation rather than iron overload. To test this possibility, the expression status of ferritin heavy chain (FTH1), transferrin receptor 1 (TFRC), hepcidin (HAMP), and ferroportin (SLC40A1) genes and promoter methylation status of FTH1 and TFR...
Source: Biochemical and Biophysical Research communications - October 2, 2022 Category: Biochemistry Authors: Jibran Sualeh Muhammad Gehad ElGhazali Jasmin Shafarin Mohammad G Mohammad Ameera Abu-Qiyas Mawieh Hamad Source Type: research
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats
Biol Pharm Bull. 2022;45(9):1269-1275. doi: 10.1248/bpb.b22-00186.ABSTRACTEdaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury (CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate the anti-CIRI mechanism of edaravone based on the nuclear factor-E2-related factor 2 (Nrf2)/ferroportin (FPN) pathway that regulates ferroptosis-mediated cerebral ischemia-reperfusion injury. We evaluated the brain injury by constructing a middle cerebral artery occlusion and reperfusion (MCAO/R) model in rats. The results showed that cerebral infarct volume and neuro...
Source: Biological and Pharmaceutical Bulletin - September 1, 2022 Category: Drugs & Pharmacology Authors: Wenpeng Liu Linlin Wang Canwen Liu Ziwei Dai Tenglong Li Biao Tang Source Type: research
Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human
CONCLUSIONS: Dysregulated iron homeostasis in both the maternal and fetal sides was implicated in preterm births, and disordered regulations in maintaining the placental iron equilibrium were also presumed to account for the compromised fetal iron supply.PMID:36046373 | PMC:PMC9423993 | DOI:10.1155/2022/1664474
Source: Disease Markers - September 1, 2022 Category: Laboratory Medicine Authors: Wei Liu Yue Wu Na Zhang Sijin Liu Li Zhou Source Type: research
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats
Biol Pharm Bull. 2022;45(9):1269-1275. doi: 10.1248/bpb.b22-00186.ABSTRACTEdaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury (CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate the anti-CIRI mechanism of edaravone based on the nuclear factor-E2-related factor 2 (Nrf2)/ferroportin (FPN) pathway that regulates ferroptosis-mediated cerebral ischemia-reperfusion injury. We evaluated the brain injury by constructing a middle cerebral artery occlusion and reperfusion (MCAO/R) model in rats. The results showed that cerebral infarct volume and neuro...
Source: Biological and Pharmaceutical Bulletin - September 1, 2022 Category: Drugs & Pharmacology Authors: Wenpeng Liu Linlin Wang Canwen Liu Ziwei Dai Tenglong Li Biao Tang Source Type: research
Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human
CONCLUSIONS: Dysregulated iron homeostasis in both the maternal and fetal sides was implicated in preterm births, and disordered regulations in maintaining the placental iron equilibrium were also presumed to account for the compromised fetal iron supply.PMID:36046373 | PMC:PMC9423993 | DOI:10.1155/2022/1664474
Source: Disease Markers - September 1, 2022 Category: Laboratory Medicine Authors: Wei Liu Yue Wu Na Zhang Sijin Liu Li Zhou Source Type: research
