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Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm
CONCLUSIONS: Hepcidin elevation in SMCs plays a protective role in the setting of AAA. These findings are the first demonstration of a protective rather than deleterious role for hepcidin in cardiovascular disease. They highlight the need to further explore the prognostic and therapeutic value of hepcidin outside disorders of iron homeostasis.PMID:36951059 | DOI:10.1161/ATVBAHA.123.319224
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 23, 2023 Category: Cardiology Authors: Paul Loick Goran Hamid Mohammad Ismail I Cassimjee Anirudh Chandrashekar Pierfrancesco Lapolla Alison Carrington Mayra Vera-Aviles Ashok Handa Regent Lee Samira Lakhal-Littleton Source Type: research
Effect of obesity and hypothyroidism on hepcidin concentration in pregnancy - a pilot study using maternal and umbilical cord blood at delivery day
J Physiol Pharmacol. 2022 Oct;73(5). doi: 10.26402/jpp.2022.5.04. Epub 2023 Mar 16.ABSTRACTHepcidin is a primary regulator of iron metabolism in the human body. By promoting ferroportin degradation, hepcidin reduces intestinal iron absorption and its release from intracellular stores. In the course of pregnancy, gradually declining hepcidin concentrations encourage placental iron transfer, thereby providing the appropriate amount of iron for fetal development. Hence, we aimed to investigate changes in maternal and cord blood hepcidin and iron metabolism parameters in normal-weight (n=17) and obese (n=17) gestating women, a...
Source: J Physiol Pharmacol - March 21, 2023 Category: Drugs & Pharmacology Authors: M Wojciechowska O W Wisniewski E Pruszynska-Oszmalek H Krauss M Sassek N Leciejewska P Kolodziejski M Wilczak Source Type: research
