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Total 1132 results found since Jan 2013.
Protective Effect of Sevoflurane Preconditioning on Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Modulating Iron Homeostasis and Ferroptosis
In conclusion, Sev relieves H/R-induced cardiomyocyte injury by regulating iron homeostasis and ferroptosis.PMID:36800141 | DOI:10.1007/s12012-023-09782-w
Source: Cardiovascular Toxicology - February 17, 2023 Category: Cardiology Authors: Hongguang Sheng Jun Xiong Danying Yang Source Type: research
Cancers, Vol. 15, Pages 1041: Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation
Conclusions: Among the 12 analyzed serum parameters of iron metabolism, increased levels of ferritin and decreased levels of sHJV had an adverse prognostic impact on survival in children after HCT. More data are needed to clarify the relationship between ferritin, sHJV, and mortality of AL children after intensive chemotherapy, and more extensive prospective studies are required to prove sHJV predictivity.
Source: Cancers - February 7, 2023 Category: Cancer & Oncology Authors: Jan Styczy ński Artur S łomka Monika Łęcka Katarzyna Albrecht Micha ł Romiszewski Monika Pogorza ła Ma łgorzata Kubicka Beata Kury ło-Rafińska Barbara Tejza Gra żyna Gadomska Ewelina Kola ńska-Dams Ma łgorzata Michalska Ewa Żekanowska Tags: Article Source Type: research
Hepcidin mimetics in polycythemia vera: resolving the irony of iron deficiency and erythrocytosis
Curr Opin Hematol. 2022 Dec 30. doi: 10.1097/MOH.0000000000000747. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Development of hepcidin therapeutics has been a ground-breaking discovery in restoring iron homeostasis in several haematological disorders. The hepcidin mimetic, rusfertide, is in late-stage clinical development for treating polycythemia vera patients with a global phase 3 trial [NCT05210790] currently underway. Rusfertide serves as the first possible noncytoreductive therapeutic option to maintain haematocrit control and avoid phlebotomy in polycythemia vera patients. In this comprehensive review, we discus...
Source: Cancer Control - February 2, 2023 Category: Cancer & Oncology Authors: Shivani Handa Yelena Ginzburg Ronald Hoffman Marina Kremyanskaya Source Type: research
Impact of maternal iron deficiency anemia on fetal iron status and placental iron transporters in human pregnancy
Blood Cells Mol Dis. 2023 Jan 27:102727. doi: 10.1016/j.bcmd.2023.102727. Online ahead of print.ABSTRACTIron deficiency anemia is associated with maternal morbidity and poor pregnancy outcomes. Heme and non-heme iron transport proteins expressed in the placenta help in adequate iron supply from anemic mother to fetus. Here we examined the expression of placental iron trafficking molecules and their association with maternal and neonatal iron status in pregnant women with iron deficiency anemia (IDA). Pregnant women who received prenatal care at Christian Medical College, Vellore, India for childbirth were recruited. Pregna...
Source: Blood Cells, Molecules and Diseases - February 1, 2023 Category: Hematology Authors: Sreenithi Santhakumar Rekha Athiyarath Anne George Cherian Vinod Joseph Abraham Biju George Pawe ł Lipiński Eunice Sindhuvi Edison Source Type: research
Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier
Conclusions : These novel findings provide a molecular mechanism for apo- and holo-Tf regulation of iron release from endothelial cells. They further demonstrate how hepcidin impacts these protein-protein interactions, and offer a model for how holo-Tf and hepcidin corporate to suppress iron release. We have established a more thorough understanding of the mechanisms behind iron release regulation with great clinical impact for a variety of neurological conditions in which iron release is dysregulated.PMID:36711476 | PMC:PMC9882672 | DOI:10.21203/rs.3.rs-2429356/v1
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Stephanie Baringer Kondaiah Palsa Ian A Simpson James R Connor Source Type: research
Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
This study has furthered our understanding on the role of Nrf2 in attenuating hemin-induced perturbations in macrophage responses and suggests a potential therapeutic target in the managemen t of DFU.
Source: Inflammopharmacology - January 20, 2023 Category: Drugs & Pharmacology Source Type: research
Structural basis of ferroportin inhibition by minihepcidin PR73
by Azaan Saalim Wilbon, Jiemin Shen, Piotr Ruchala, Ming Zhou, Yaping Pan
Ferroportin (Fpn) is the only known iron exporter in humans and is essential for maintaining iron homeostasis. Fpn activity is suppressed by hepcidin, an endogenous peptide hormone, which inhibits iron export and promotes endocytosis of Fpn. Hepcidin deficiency leads to hemochromatosis and iron-loading anemia. Previous studies have shown that small peptides that mimic the first few residues of hepcidin, i.e., minihepcidins, are more potent than hepcidin. However, the mechanism of enhanced inhibition by minihepcidins remains unclear. Here, we report ...
Source: PLoS Biology: Archived Table of Contents - January 17, 2023 Category: Biology Authors: Azaan Saalim Wilbon Source Type: research
Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitored in case (active tuberculosis patients: ATB) and control (non-tuberculosis: NTB and healthy) study populations (n = 72, male: 100%, mean age, 42.94 years; range, 17–83 years). Using serum elemental and cytokine levels, a partial least square discriminate analysis model (PLS-DA) was built, which clustered ATB patients away from NTB and healthy controls. Based on the PLS-DA variable importance in projection (...
Source: Frontiers in Immunology - January 12, 2023 Category: Allergy & Immunology Source Type: research
Ferroportin depletes iron needed for cell cycle progression in head and neck squamous cell carcinoma
ConclusionsOur results indicate that iron plays a role in HNSCC cell proliferation and growth and is important for cell cycle progression. Iron based interventional strategies such as ferroptosis or iron chelation may have potential therapeutic benefits in advanced HNSCC.
Source: Frontiers in Oncology - January 9, 2023 Category: Cancer & Oncology Source Type: research
The expression of proteins associated with iron metabolism in the human placenta complicated with preeclampsia
Hepcidin and Ferroportin are key iron-regulatory hormones that play a role in controlling the delivery of iron to blood plasma from iron storage. Recent reports suggest aberrant iron metabolism is associated with preeclampsia. We aimed to observe whether these proteins express in the human placenta or not, and compare their expression according to the complication of preeclampsia.
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Haemin Kim, Hyo-shin Kim, Hyun Mi Kim, Mi Ju Kim, Hyun-Hwa Cha, Won Joon Seong Tags: Poster Session I Source Type: research
