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Total 1132 results found since Jan 2013.

Anemia, Iron Deficiency, and Iron Regulators in Pancreatic Ductal Adenocarcinoma Patients: A Comprehensive Analysis
This study investigated the incidence and characteristics of anemia and micronutrient deficiencies in PDAC patients before initiating chemotherapy. A total of 103 PDAC patients were included, comprising 67 in the palliative and 36 in the adjuvant groups. The overall incidence of anemia was 42.7% (n = 44), with comparable rates in both groups. Normocytic and normochromic anemia were predominant, with mild and moderate cases observed in 32% and 10.7% of the cohort, respectively. ID was evident in 51.4% of patients, with absolute ID more frequent in the adjuvant than in the palliative group (19.4% vs. 13.4%). Functional ID oc...
Source: Current Oncology - August 25, 2023 Category: Cancer & Oncology Authors: Malgorzata Osmola Beata Gierej Katarzyna Mleczko-Sanecka Aneta Jo ńczy Olga Ciepiela Leszek Kraj Bogna Ziarkiewicz-Wr óblewska Grzegorz W ładysław Basak Source Type: research

Serum iron levels in tuberculosis patients and household contacts and its association with natural resistance ‐associated macrophage protein 1 polymorphism and expression
ConclusionComparing the TB case to the household contacts group, decreased serum Fe levels were discovered in the TB case group. This study also shows a correlation ofNRAMP1 gene expression to Fe levels in TB patients and household contacts and describes that TB may lead to decreased Fe levels by downregulatingNRAMP1 expression.
Source: The Clinical Respiratory Journal - August 23, 2023 Category: Respiratory Medicine Authors: Wiendra Waworuntu, Francisca Srioetami Tanoerahardjo, Anwar Mallongi, Ahyar Ahmad, Muhammad Amin, Irawaty Djaharuddin, Agussalim Bukhari, Nur Ahmad Tabri, Burhanuddin Bahar, Najdah Hidayah, Handayani Halik, Muhammad Nasrum Massi Tags: ORIGINAL ARTICLE Source Type: research

Myeloid Hif2 α is not essential to maintain systemic iron homeostasis
Systemic iron homeostasis is tightly regulated as both excess and deficiency of iron have deleterious effects. Despite tight systemic regulation, more than one billion people worldwide suffer from iron-related disorders [1,2]. Systemic iron homeostasis requires heterotissue communication. Diet is the sole source of iron, and it is actively absorbed in the small intestine through the transporter divalent metal transporter-1 (Dmt1; gene name Slc11a2) [3,4]. Iron is stored within enterocyte in an iron storage protein, ferritin (FTN) or exported out of the cell and into the circulation through the only known mammalian iron exp...
Source: Experimental Hematology - August 8, 2023 Category: Hematology Authors: Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah Tags: Article Source Type: research

Estimation of serum ferroportin and liver enzymes in breast cancer patients
Conclusion: the study concluded that breast cancer was associated with elevated AST, and ALT with reduced FPN and no changes reported with TSB levels.PMID:37522771
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Z Aziz E Sarhat Z Zaidan Source Type: research

Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis
In conclusion, these findings suggest that CVB-D alleviated sepsis-induced cardiac iron toxicity by alleviating iron metabolism.PMID:37522059 | PMC:PMC10375449 | DOI:10.3892/etm.2023.12106
Source: Experimental and Therapeutic Medicine - July 31, 2023 Category: General Medicine Authors: Jianxin Wang Peng Guan Yu Chen Meng Xu Na Wang Ensheng Ji Source Type: research