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Total 1132 results found since Jan 2013.

Iron Homeostasis in Mice: Does Liver Lobe Matter?
In this study, we compared iron-related parameters in distinct liver lobes of C57BL/6 wild-type mice across different ages. We found that the non-heme iron levels, as well as the mRNA and protein expression of iron storage protein Ferritin and the iron importer Transferrin Receptor 1, were similar between liver lobes. Additionally, the mRNA expression of Hepcidin, as well as its regulators, Bmp2 and Bmp6, and iron importers Zip8 and Zip14 were comparable. Minor differences were observed in Ferroportin mRNA levels of 24-weeks old mice; however, this did not correlate with altered iron content. The findings in wild-type mice...
Source: Am J Physiol Gastroi... - September 5, 2023 Category: Gastroenterology Authors: Silvia Colucci Tiago Carvalho Oliveira Martina U Muckenthaler Oriana Marques Source Type: research

Amyloid ‐β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo‐ and holo‐transferrin
We propose that in response to amyloid- β (Aβ), astrocytes increase their mitochondrial activity, partially in response to an increase of energetic needs due to Aβ clearance. This is accompanied by an increase of iron uptake and consumption, leaving an iron deficient environment in the extracellular space and elevated levels of apo (ir on free)- transferrin (Tf). Apo-Tf stimulates iron release from endothelial cells (ECs), resulting in an increase of iron transport across the blood–brain barrier through ferroportin. AbstractExcessive brain iron accumulation is observed early in the onset of Alzheimer's disease, notabl...
Source: Journal of Neurochemistry - September 5, 2023 Category: Neuroscience Authors: Stephanie L. Baringer, Avraham S. Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S. Lippmann, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor Tags: ORIGINAL ARTICLE Source Type: research

Dyshomeostasis of Iron and Its Transporter Proteins in Cypermethrin-Induced Parkinson ’s Disease
AbstractThe etiology of Parkinson ’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of pesticides and transition metals. Copper, magnesium, iron, and zinc have emerged as important metal contributors. Exposure to pesticides causes an accumulation of transition m etals in the substantia nigra (SN) region of the brain. The cypermethrin model of PD is characterized by mitochondrial dysfunction, autophagy impairment, oxidative stress, etc. However, the effect of cypermethrin on metal homeostasis is not yet explored. The study was designed to delineate the ...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

Anemia, Iron Deficiency, and Iron Regulators in Pancreatic Ductal Adenocarcinoma Patients: A Comprehensive Analysis
This study investigated the incidence and characteristics of anemia and micronutrient deficiencies in PDAC patients before initiating chemotherapy. A total of 103 PDAC patients were included, comprising 67 in the palliative and 36 in the adjuvant groups. The overall incidence of anemia was 42.7% (n = 44), with comparable rates in both groups. Normocytic and normochromic anemia were predominant, with mild and moderate cases observed in 32% and 10.7% of the cohort, respectively. ID was evident in 51.4% of patients, with absolute ID more frequent in the adjuvant than in the palliative group (19.4% vs. 13.4%). Functional ID oc...
Source: Current Oncology - August 25, 2023 Category: Cancer & Oncology Authors: Malgorzata Osmola Beata Gierej Katarzyna Mleczko-Sanecka Aneta Jo ńczy Olga Ciepiela Leszek Kraj Bogna Ziarkiewicz-Wr óblewska Grzegorz W ładysław Basak Source Type: research