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Role and interest of hepcidin in iron homeostasis
Ann Biol Clin (Paris). 2023 May 16;81(2):111-124. doi: 10.1684/abc.2023.1805.ABSTRACTIron is an essential element to the well functionning of the organism and requires careful maintenance of its homeostasis. This is mainly due to hepcidin, a hormone secreted by the liver that controls the flow of iron within the body. It has a hyposideremic action by reducing the expression of ferroportin, the only protein known to this day, which can export iron into the extracellular environment. This has the effect of decreasing intestinal absorption and increasing intracellular retention, especially in macrophages. Hepcidin is stimulat...
Source: Annales de Biologie Clinique - May 15, 2023 Category: Biochemistry Authors: Julien Miozzo C écile Meunier Sophie Park Patrice Faure Laetitia Van Noolen Source Type: research
