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Total 1132 results found since Jan 2013.
Effect of obesity and hypothyroidism on hepcidin concentration in pregnancy - a pilot study using maternal and umbilical cord blood at delivery day
J Physiol Pharmacol. 2022 Oct;73(5). doi: 10.26402/jpp.2022.5.04. Epub 2023 Mar 16.ABSTRACTHepcidin is a primary regulator of iron metabolism in the human body. By promoting ferroportin degradation, hepcidin reduces intestinal iron absorption and its release from intracellular stores. In the course of pregnancy, gradually declining hepcidin concentrations encourage placental iron transfer, thereby providing the appropriate amount of iron for fetal development. Hence, we aimed to investigate changes in maternal and cord blood hepcidin and iron metabolism parameters in normal-weight (n=17) and obese (n=17) gestating women, a...
Source: J Physiol Pharmacol - March 21, 2023 Category: Drugs & Pharmacology Authors: M Wojciechowska O W Wisniewski E Pruszynska-Oszmalek H Krauss M Sassek N Leciejewska P Kolodziejski M Wilczak Source Type: research
Comparative analysis of the functional properties of human and mouse ferroportin
We examined the functional properties of human Fpn, mouse Fpn, and mutant mouse Fpn by using radiotracer assays in RNA-injected Xenopus oocytes. We found that neither mouse nor human Fpn transports manganese. Mouse and human Fpn share identical properties with respect to substrate profile, calcium dependence, optimal pH, and hepcidin sensitivity. We have also demonstrated that Fpn is not an ATPase pump. Our findings validate the use of mouse models of ferroportin function in iron homeostasis and disease.PMID:36939203 | DOI:10.1152/ajpcell.00063.2023
Source: Am J Physiol Cell Ph... - March 20, 2023 Category: Cytology Authors: Corbin R Azucenas T Alex Ruwe John P Bonamer Bo Qiao Tomas Ganz Mika Jormakka Elizabeta Nemeth Bryan Mackenzie Source Type: research
