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Total 1132 results found since Jan 2013.
Iron metabolism abnormalities in autoimmune hemolytic anemia and < em > Jianpishengxue keli < /em > can ameliorate hemolysis and improve iron metabolism in AIHA mouse models
CONCLUSION: Iron metabolism abnormalities exists in AIHA patients and Jianpishengxue keli can ameliorate hemolysis and improve iron metabolism in AIHA mouse models.KEY MESSAGESIron metabolism abnormalities exists in hemolytic episode AIHA patients. Hepcidin and ferritin levels significantly elevated and also correlated with the severity of AIHA patients. Jianpishengxue keli can ameliorate hemolysis and prompt the recovery of AIHA.PMID:36576329 | DOI:10.1080/07853890.2022.2157475
Source: Annals of Medicine - December 28, 2022 Category: Internal Medicine Authors: Manjun Zhao Yan Wang Jin Yang Yi Wang Yingying Feng Lei Chen Zonghong Shao Huaquan Wang Limin Xing Source Type: research
Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: potential implications for SARS-CoV-2 infection
Conclusions: Whilst our results demonstrate upregulation of ACE2 gene and protein in hPAECs in response to iron regulatory elements, such as hepcidin and IL-6, further studies need to be undertaken to establish if such effects result in enhanced SARS-CoV-2 infection and whether modulation of this axis may be protective.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Toe, Q. K., Issitt, T., Mahomed, A., Sturges, C., Wort, S. J., Quinlan, G. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research
Quercetin Alleviates Subarachnoid Hemorrhage-induced Early Brain Injury via Inhibiting Ferroptosis in the rat model
In conclusion, our study revealed that QCT might alleviate the EBI by inhibiting ferroptosis in SAH rats.PMID:36437694 | DOI:10.1002/ar.25130
Source: Anatomical Record - November 28, 2022 Category: Anatomy Authors: Dian Jiao Jianmiao Xu Chengjian Lou Yuhuan Luo Chengtao Ni Guanghong Shen Marong Fang Xiangyang Gong Source Type: research
Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes
CONCLUSION: Repression of ferroportin at the transcriptional and post-transcriptional level may contribute to iron accumulation in hepatocytes observed in a subset of patients with T2DM.PMID:36436807 | DOI:10.1016/j.molmet.2022.101644
Source: Molecular Medicine - November 27, 2022 Category: Molecular Biology Authors: Ruiyue Qiu Kristina Alikhanyan Nadine Volk Oriana Marques Christina Mertens Anand Ruban Agarvas Sanjana Singh Rainer Pepperkok Sandro Altamura Martina U Muckenthaler Source Type: research
GSE206109 Effect of ferroportin on placental gene expression
Contributors : Chang Cao ; Mark D FlemingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the function of ferroportin, we deleted ferroportin gene in mouse placenta using cre.We performed RNA-sequencing on six ferroportin knockout and four control placentas.
Source: GEO: Gene Expression Omnibus - November 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Genetic Variations of ferroportin-1(FPN1-8CG), TMPRSS6 (rs855791) and Hemojuvelin (I222N and G320V) Among a Cohort of Egyptian β-Thalassemia Major Patients
AbstractIron overload remains a major cause of morbidity and mortality among β-thalassemia major (β-TM) patients. Iron regulatory proteins and their genetic variants together with changes in hepcidin levels in thalassemic patients could affect the disease manifestations. This work aimed to study genetic variations of ferroportin-1 (FPN1-8CG), Transmembrane Serine Protease 6 (TMPRSS6 rs855791) and hemojuvelin (HJV I222N and G320V) genes within a cohort of 97 β-TM Egyptian patients by Polymerase chain reaction Restriction Fragment Length Polymorphism (PCR-RFLP) in comparison to fifty normal control subjects. Among β-TM p...
Source: Indian Journal of Hematology and Blood Transfusion - November 1, 2022 Category: Hematology Source Type: research
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice
Free Radic Biol Med. 2022 Oct 26:S0891-5849(22)00945-5. doi: 10.1016/j.freeradbiomed.2022.10.314. Online ahead of print.ABSTRACTNuclear factor-E2-related factor 2 (Nrf2) expression in sperm decreases in some oligospermia patients. However, the mechanism of reduced Nrf2 expression in sperm of oligospermia men is not elucidated. In the present study, our clinical trial results showed that Nrf2 and glutathione peroxidase 4 (GPX4) protein expressions in sperm of oligospermia men significantly decreased than those of healthy men. In animal experiments, mice were randomly divided into 3 groups: wild type (WT), Nrf2 knockout (Nrf...
Source: Free Radical Biology and Medicine - October 29, 2022 Category: Biology Authors: Ping Han Xia Wang Tianqiu Zhou Jinmei Cheng Chengniu Wang Fei Sun Xi Zhao Source Type: research
Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia
In conclusion, TBN regulates the AMPK/mTOR/4E-BP1/HIFs pathway, and activates the hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia.
Source: Frontiers in Pharmacology - October 17, 2022 Category: Drugs & Pharmacology Source Type: research
Endometriosis-associated mesenchymal stem cells support ovarian clear cell carcinoma through iron regulation
In this study, we identified a subset of endometriosis derived mesenchymal stem cells (enMSCs) characterized by loss of CD10 expression that specifically support OCCC growth. RNA sequencing identified alterations in iron export in CD10 negative enMSCs and reciprocal changes in metal transport in co-cultured OCCC cells. CD10 negative enMSCs exhibited elevated expression of iron export proteins hephaestin and ferroportin and donate iron to associated OCCCs, functionally increasing the levels of labile intracellular iron. Iron is necessary for OCCC growth, and CD10-negative enMSCs prevented the growth inhibitory effects of ir...
Source: Cell Research - October 11, 2022 Category: Cytology Authors: Huda I Atiya Leonard Frisbie Ester Goldfeld Taylor Orellana Nicole Donellan Francesmary Modugno Michael Calderon Simon C Watkins Rugang Zhang Esther Elishaev Thing Rinda Soong Anda M Vlad Lan G Coffman Source Type: research
Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects
J Mol Med (Berl). 2022 Oct 10. doi: 10.1007/s00109-022-02254-8. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is one of the most common chronic liver diseases. Its pathological spectrum includes the overlapping stages of hepatic steatosis/steatohepatitis that can progress to liver fibrosis and cirrhosis; both are risk factors for hepatocellular carcinoma. Moreover, ALD diagnosis and management pose several challenges. The early pathological stages are reversible by alcohol abstinence, but these early stages are often asymptomatic, and currently, there is no specific laboratory biomarker or diagnostic...
Source: Molecular Medicine - October 10, 2022 Category: Molecular Biology Authors: Kevin Ferrao Najma Ali Kosha J Mehta Source Type: research
