This page shows you your search results in order of date. This is page number 11.
Order by Relevance | Date
Total 58416 results found since Jan 2013.
Altered microRNA expression in patients with sarcoidosis
Conclusion This is the first miRNA report of differentially expressed miRNAs in the serum of patients with sarcoidosis and matched healthy controls in South Africa. The results obtained suggest that miRNAs may play a role in sarcoidosis pathogenesis. Whether these molecules have diagnostic or prognostic implications, needs future studies recruiting larger patient cohorts.PMID:37712378 | DOI:10.36141/svdld.v40i3.13399
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Rajen Morar Caroline Dickens Therese Dix-Peek Raquel Duarte Charles Feldman Source Type: research
The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)
Oncol Rep. 2023 Oct;50(4):190. doi: 10.3892/or.2023.8627. Epub 2023 Sep 15.ABSTRACTThe characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence and development of these pathologi...
Source: Oncology Reports - September 15, 2023 Category: Cancer & Oncology Authors: Chaozhe Wang Xidi Wang Danfeng Zhang Xiaolin Sun Yunhua Wu Jing Wang Qing Li Guosheng Jiang Source Type: research
GSE242888 High-throughput sequencing to investigate the expression and potential role of differentially expressed microRNAs in ischemia –reperfusion myocardial cells
Contributor : Senjie LiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusMicroRNAs are closely associated with the pathogenesis of various diseases, but the relationship between miRNAs and myocardial ischemia –reperfusion (I/R) injury remains unclear. Therefore, we aimed to explore the role and function of miRNAs in I/R. We established hypoxia/reoxygenation (H/R) model to detect differentially expressed miRNAs using high-throughput sequencing in rat myocardial cell. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment were used to analyse the potential functio...
Source: GEO: Gene Expression Omnibus - September 15, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE242828 Real-time quantitative PCR analysis of rat's brain miRNAs
Contributor : Diana SalikhovaSeries Type : OtherOrganism : Rattus norvegicusWe investigated the therapeutic effect of the extracellular vesicles secreted by glial progenitor cells (GPC-EV) derived from human induced pluripotent stem cell in a traumatic brain injury model. The injury was modeled using the dosed concussion to the open brain method. The male Wistar rats were performed traumatic brain injury (TBI), and after 24 hours animals were randomly divided into two groups: group 1 — rats with intranasal administration of PBS (control), and group 2 — rats with similar administration of extracellular visicles (EV) der...
Source: GEO: Gene Expression Omnibus - September 15, 2023 Category: Genetics & Stem Cells Tags: Other Rattus norvegicus Source Type: research
GSE234464 Expression profiling in exosomal miRNAs of diabetes, diabetes with coronary microcirculation disorder, and diabetes with coronary artery disease
Contributors : Y H Liu ; L N KangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensDue to the insidious onset and the difficulty to diagnose and intervene, it is particularly important to find the diagnostic markers of diabetic coronary microcirculation disorder (CMD) and therapeutic targets. Circulating exosomes, as endogenous exosomes derived from multiple tissue cells, mediate communication between cells and tissues, may serve as a key point for future diagnosis, prognosis and personalized treatment of CMD in diabetes. Therefore, we isolated serum exosomes from patients with diab...
Source: GEO: Gene Expression Omnibus - September 15, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
MicroRNA based combinatorial therapy against TKIs resistant CML by inactivating the PI3K/Akt/mTOR pathway: a review
AbstractChronic myeloid leukemia (CML) is characterized by presence of Philadelphia chromosome, which harborsBCR-ABL oncogene responsible for encoding BCR-ABL oncoprotein. This oncoprotein interferes with cellular signaling pathways, resulting in tumor progression. Among these pathways, PI3K/Akt/mTOR pathway is significantly upregulated in CML. Tyrosine kinase inhibitors (TKIs) are current standard therapy for CML, and they have shown remarkable efficacy. However, emergence of TKIs drug resistance has necessitated investigation of novel therapeutic approaches. Components of PI3K/Akt/mTOR pathway have emerged as attractive ...
Source: Medical Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research
A new perspective on Alzheimer ’s disease: microRNAs and circular RNAs
microRNAs (miRNAs) play a multifaceted role in the pathogenesis of Alzheimer’s disease (AD). miRNAs regulate several aspects of the disease, such as Aβ metabolism, tau phosphorylation, neuroinflammation, and synaptic function. The dynamic interaction between miRNAs and their target genes depends upon various factors, including the subcellular localization of miRNAs, the relative abundance of miRNAs and target mRNAs, and the affinity of miRNA-mRNA interactions. The miRNAs are released into extracellular fluids and subsequently conveyed to specific target cells through various modes of transportation, such as exosomes. In...
Source: Frontiers in Genetics - September 15, 2023 Category: Genetics & Stem Cells Source Type: research
Circulating MicroRNAs in the Screening of Prenatal Down Syndrome
CONCLUSION: In light of these data, we believe that miRNAs may have an important role in the noninvasive prenatal diagnosis of fetal birth defects, especially Down syndrome.PMID:37709679
Source: Puerto Rico Health Sciences Journal - September 14, 2023 Category: International Medicine & Public Health Authors: Senay Balci Filiz Cayan Gurbet Dogru Ozdemir Mustafa Ertan Ay Didem Derici Yildirim Lulufer Tamer Source Type: research
Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine
CONCLUSION: In our study, an in-depth exploration of the mRNA expression and miRNA activity of macrophages, microglia, epididymal cells, neurons and vascular smooth muscle cells during TBM progression was conducted using scRNA-Seq, which provided novel insights into the immune cell engagement in TBM patients.PMID:37708706 | DOI:10.1016/j.intimp.2023.110871
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Xiaolin Zhang Lei Pan Peng Zhang Lei Wang Yidan Shen Ping Xu Yang Ren Wei Huang Ping Liu Qingguo Wu Feng Li Source Type: research
Dumbbell hybridization chain reaction coupled with positively charged Au@luminol nanoparticles for enhanced electrochemiluminescent sensing of exosomal miRNA-21
Bioelectrochemistry. 2023 Sep 6;155:108556. doi: 10.1016/j.bioelechem.2023.108556. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are important cancer biomarkers in cancer cell-derived exosomes. Herein, positively charged Au@luminol nanoparticles ((+)Au@luminol NPs) with enhanced electrochemiluminescence (ECL) and extreme stability were firstly established for the sensitive detection of miRNA-21 in exosome. In the presence of miRNA-21, dumbbell hybridization chain reaction (DHCR) happened at gold nanoparticles and ZIF-67 metal-organic framework modified glass carbon electrode (AuNP/ZIF-MOF/GCE) with the help of dumbbell ...
Source: Bioelectrochemistry - September 14, 2023 Category: Biochemistry Authors: Yun Zhang Shiqiang Li Chenxu Peng Zhe Shi Xiangmin Miao Source Type: research
Comprehensive analysis of OsJAZ gene family deciphers rhizobacteria-mediated nutrient stress modulation in rice
Int J Biol Macromol. 2023 Sep 12:126832. doi: 10.1016/j.ijbiomac.2023.126832. Online ahead of print.ABSTRACTThe JASMONATE-ZIM DOMAIN (JAZ) repressors are crucial proteins in jasmonic acid signaling pathway that are critical for plant growth. Therefore, the present study aimed to identify and characterize OsJAZs in the rice genome, revealing their structural attributes, regulatory elements, miRNA interactions, and subcellular localization. 23 JAZ transcripts across the 6 chromosomes of rice genome were identified having conserved domains and different physiochemical characteristics. Phylogenetically classified into five cla...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Nikita Bisht Anshu Anshu Poonam C Singh Puneet Singh Chauhan Source Type: research
Integrative transcriptomic analysis unveils lncRNA-miRNA-mRNA interplay in tomato plants responding to Ralstonia solanacearum
Int J Biol Macromol. 2023 Sep 12:126891. doi: 10.1016/j.ijbiomac.2023.126891. Online ahead of print.ABSTRACTRalstonia solanacearum, a bacterial plant pathogen, poses a significant threat to tomato (Solanum lycopersicum) production through destructive wilt disease. While noncoding RNA has emerged as a crucial regulator in plant disease, its specific involvement in tomato bacterial wilt remains limited. Here, we conducted a comprehensive analysis of the transcriptional landscape, encompassing both mRNAs and noncoding RNAs, in a tomato resistant line ('ZRS_7') and a susceptible line ('HTY_9') upon R. solanacearum inoculation ...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Xiuyang Si Hongyan Liu Xi Cheng Chengcui Xu Zhanghui Han Zhongren Dai Rongqing Wang Changtian Pan Gang Lu Source Type: research
Progress in quantum dot-based biosensors for microRNA assay: A review
Anal Chim Acta. 2023 Oct 16;1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.ABSTRACTMicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based bios...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wen-Jing Liu Li-Juan Wang Chun-Yang Zhang Source Type: research
Circadian system microRNAs - Role in the development of cardiovascular diseases
Adv Protein Chem Struct Biol. 2023;137:225-267. doi: 10.1016/bs.apcsb.2023.02.004. Epub 2023 Feb 25.ABSTRACTCircadian rhythm regulates numerous physiological processes, and disruption of the circadian clock can lead to cardiovascular disease. Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Small non-coding RNAs, microRNAs (miRNAs), are involved in regulating gene expression, both those important for the cardiovascular system and key circadian clock genes. Epigenetic mechanisms based on miRNAs are essential for fine-tuning circadian physiology. Indeed, some miRNAs depend on circadian period...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ivana Škrlec Source Type: research
Bioinspired superhydrophobic SERS substrates for machine learning assisted miRNA detection in complex biomatrix below femtomolar limit
Anal Chim Acta. 2023 Oct 16;1278:341708. doi: 10.1016/j.aca.2023.341708. Epub 2023 Aug 11.ABSTRACTSurface-enhanced Raman spectroscopy (SERS) is an analytical method with high potential in the field of medicine. The design of SERS substrates, based on specific morphology and/or chemical modification, allow the recognition of the presence of specific analytes with precision close to a single-molecule detection limit. However, the SERS analysis of real samples is significantly complicated by the presence of a large number of "minor" molecules that can shield the signal from the target analyte and make it impossible to determi...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: A Zabelina A Trelin A Skvortsova D Zabelin V Burtsev E Miliutina V Svorcik O Lyutakov Source Type: research
