This page shows you your search results in order of date. This is page number 7.
Order by Relevance | Date
Total 58416 results found since Jan 2013.
The linkage between microRNA and cancer and its delivery as cancer therapy: A mini-review
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):7-18. doi: 10.14715/cmb/2023.69.7.2.ABSTRACTThe central dogma of molecular biology was no longer "central" after ground-breaking discoveries conveyed gene expression involves more complex physiological functions in cancer pathogenesis over the last decade. MicroRNAs (miRNAs) are short non-coding RNA that regulate gene expression, affecting key molecular pathways involved in sustaining the proliferative signalling for tumour development, evasion of cellular death, invasion, angiogenesis, as well as metastasis in a plethora of cancer types. MiRNA expression is dysregulated in...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Syed Umar Faruq Syed Najmuddin Ammar Akram Kamarudin Suraya Abdul Sani Mohd Nor Faiz Norrrahim Nur 'Atikah Abdul Latif Lucky Goh Poh Wah Source Type: research
Integrated bioinformatics analysis of microarray data from non-small cell lung cancer
In conclusion, the identification of hsa-miR-21, hsa-miR-141, hsa-miR-200b hsa-miR-30a, hsa-miR-30d and hsa-miR-145 provides a new theoretical basis for understanding the development of NSCLC.PMID:37715441 | DOI:10.14715/cmb/2023.69.7.35
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Lulu Feng Wenping Cai Shan Jin Caipu Chun Chengyan Wang Luping Ma Hao Peng Xingxing Dong Jinfang Jiang Xianling Lu Lijuan Pang Source Type: research
MiRNA a New Insight in Metabolic and Human Diseases: A Review
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):102-110. doi: 10.14715/cmb/2023.69.8.16.ABSTRACTThe purpose of this research is to examine existing studies on the association between microRNAs (miRNA) and age-related disorders. The miRNAs are small, noncoding RNA molecules with the ability to regulate gene expression. These are well-established in extracellular circulation, including various types of diseases such as cancer, cardiovascular diseases, and diabetes. Similarly, several miRNAs are associated with certain age-related conditions, such as increased miR-21 expression in cancer patients. Besides that, the miR-122 ...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Ibrahim Jafri Source Type: research
Dysregulation of Micrornas in Adult Osteogenesis Imperfecta: The Miroi Study
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - September 16, 2023 Category: Orthopaedics Authors: Alexandre Mercier ‐Guery,
Marjorie Millet,
Blandine Merle,
Corinne Collet,
Flora Bagouet,
Olivier Borel,
Elisabeth Sornay‐Rendu,
Pawel Szulc,
Emmanuelle Vignot,
Deborah Gensburger,
Elisabeth Fontanges,
Martine Croset,
Roland Chapurlat Tags: Clinical Trial Source Type: research
Circulating microRNAs can predict chemotherapy-induced toxicities in patients being treated for primary breast cancer
ConclusionThis is the first study which illustrates the value of measuring circulatory miRNA to predict patient-specific toxicities to NAC. These results support the ideology that circulatory miRNAs are biomarkers with utility in predicting chemotherapy toxicity as well as treatment response.
Source: Breast Cancer Research and Treatment - September 15, 2023 Category: Cancer & Oncology Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
J Virol. 2023 Sep 15:e0073023. doi: 10.1128/jvi.00730-23. Online ahead of print.ABSTRACTViruses use miRNAs to enable efficient replication, control host defense mechanisms, and regulate latent infection. Herpes simplex virus 1 (HSV-1) expresses multiple miRNAs whose functions are largely unknown. The evolutionary conservation of many HSV-1 miRNAs in the closely related HSV-2 suggests their functional importance. miRNAs, similar to other transcripts, can undergo various post-transcriptional modifications that may affect their biogenesis, stability, and targeting. To investigate whether editing occurs in HSV-1 miRNAs, we seq...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Andreja Zubkovi ć Cristina Gomes Adwait Parchure Mia Cesarec Antun Feren čić Filip Roki ć Hrvoje Jakovac Abigail L Whitford Sara A Dochnal Anna R Cliffe Dra žen Cuculić Angela Gallo Oliver Vugrek Michael Hackenberg Igor Jurak Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
Altered microRNA expression in patients with sarcoidosis
Conclusion This is the first miRNA report of differentially expressed miRNAs in the serum of patients with sarcoidosis and matched healthy controls in South Africa. The results obtained suggest that miRNAs may play a role in sarcoidosis pathogenesis. Whether these molecules have diagnostic or prognostic implications, needs future studies recruiting larger patient cohorts.PMID:37712378 | DOI:10.36141/svdld.v40i3.13399
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Rajen Morar Caroline Dickens Therese Dix-Peek Raquel Duarte Charles Feldman Source Type: research
Serum ‑derived exosomal hsa‑let‑7b‑5p as a biomarker for predicting the severity of coronary stenosis in patients with coronary heart disease and hyperglycemia
In conclusion, the present study demonstrated that serum‑derived exosomal hsa‑let‑7b‑5p is upregulated in patients with CHD and hyperglycemia, and may serve as a noninvasive biomarker for the severity of coronary stenosis.PMID:37711034 | DOI:10.3892/mmr.2023.13090
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Shufang Han Jie Fang Lili Yu Bin Li Yuhong Hu Ruimin Chen Changyong Li Chuanxu Zhao Jiaying Li Yinan Wang Yuqi Gao Hong Tan Qun Jin Source Type: research
Circulating miRNAs detect high versus low visceral adipose tissue inflammation in patients living with obesity
CONCLUSIONS: Circ-miRs that identify patients with low versus high VAT inflammation constitute a putative tool to improve personalized care of patients with obesity.PMID:37713174 | DOI:10.1210/clinem/dgad550
Source: The Journal of Clinical Endocrinology and Metabolism - September 15, 2023 Category: Endocrinology Authors: Nataly Makarenkov Yulia Haim Uri Yoel Yair Pincu Tanya Tarnovscki Idit F Liberty Ivan Kukeev Lior Baraf Oleg Dukhno Oleg Zilber Matthias Bl üher Assaf Rudich Isana Veksler-Lublinsky Source Type: research
The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)
Oncol Rep. 2023 Oct;50(4):190. doi: 10.3892/or.2023.8627. Epub 2023 Sep 15.ABSTRACTThe characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence and development of these pathologi...
Source: Oncology Reports - September 15, 2023 Category: Cancer & Oncology Authors: Chaozhe Wang Xidi Wang Danfeng Zhang Xiaolin Sun Yunhua Wu Jing Wang Qing Li Guosheng Jiang Source Type: research
Serum ‑derived exosomal hsa‑let‑7b‑5p as a biomarker for predicting the severity of coronary stenosis in patients with coronary heart disease and hyperglycemia
In conclusion, the present study demonstrated that serum‑derived exosomal hsa‑let‑7b‑5p is upregulated in patients with CHD and hyperglycemia, and may serve as a noninvasive biomarker for the severity of coronary stenosis.PMID:37711034 | DOI:10.3892/mmr.2023.13090
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Shufang Han Jie Fang Lili Yu Bin Li Yuhong Hu Ruimin Chen Changyong Li Chuanxu Zhao Jiaying Li Yinan Wang Yuqi Gao Hong Tan Qun Jin Source Type: research
HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
J Virol. 2023 Sep 15:e0073023. doi: 10.1128/jvi.00730-23. Online ahead of print.ABSTRACTViruses use miRNAs to enable efficient replication, control host defense mechanisms, and regulate latent infection. Herpes simplex virus 1 (HSV-1) expresses multiple miRNAs whose functions are largely unknown. The evolutionary conservation of many HSV-1 miRNAs in the closely related HSV-2 suggests their functional importance. miRNAs, similar to other transcripts, can undergo various post-transcriptional modifications that may affect their biogenesis, stability, and targeting. To investigate whether editing occurs in HSV-1 miRNAs, we seq...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Andreja Zubkovi ć Cristina Gomes Adwait Parchure Mia Cesarec Antun Feren čić Filip Roki ć Hrvoje Jakovac Abigail L Whitford Sara A Dochnal Anna R Cliffe Dra žen Cuculić Angela Gallo Oliver Vugrek Michael Hackenberg Igor Jurak Source Type: research
