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Total 58416 results found since Jan 2013.

Progress in quantum dot-based biosensors for microRNA assay: A review
Anal Chim Acta. 2023 Oct 16;1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.ABSTRACTMicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based bios...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wen-Jing Liu Li-Juan Wang Chun-Yang Zhang Source Type: research

Bioinspired superhydrophobic SERS substrates for machine learning assisted miRNA detection in complex biomatrix below femtomolar limit
Anal Chim Acta. 2023 Oct 16;1278:341708. doi: 10.1016/j.aca.2023.341708. Epub 2023 Aug 11.ABSTRACTSurface-enhanced Raman spectroscopy (SERS) is an analytical method with high potential in the field of medicine. The design of SERS substrates, based on specific morphology and/or chemical modification, allow the recognition of the presence of specific analytes with precision close to a single-molecule detection limit. However, the SERS analysis of real samples is significantly complicated by the presence of a large number of "minor" molecules that can shield the signal from the target analyte and make it impossible to determi...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: A Zabelina A Trelin A Skvortsova D Zabelin V Burtsev E Miliutina V Svorcik O Lyutakov Source Type: research

Circulating MicroRNAs in the Screening of Prenatal Down Syndrome
CONCLUSION: In light of these data, we believe that miRNAs may have an important role in the noninvasive prenatal diagnosis of fetal birth defects, especially Down syndrome.PMID:37709679
Source: Puerto Rico Health Sciences Journal - September 14, 2023 Category: International Medicine & Public Health Authors: Senay Balci Filiz Cayan Gurbet Dogru Ozdemir Mustafa Ertan Ay Didem Derici Yildirim Lulufer Tamer Source Type: research

MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands
In conclusion, bta-miR-223 mitigated inflammation and oxidative injury by d ownregulating the NLRP3 inflammasome and Keap1/Nrf2 signaling pathway. This study implicated bta-miR-223 in regulation of inflammatory responses, with potential as a novel target for treating bovine mastitis and other diseases.
Source: Veterinary Research - September 14, 2023 Category: Veterinary Research Source Type: research

MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
AbstractHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected patients to unravel the molecular mechanisms of coinfection. EVs were purified and charac...
Source: Journal of Molecular Medicine - September 14, 2023 Category: Molecular Biology Source Type: research

Comprehensive analysis of ceRNA network composed of circRNA, miRNA, and mRNA in septic acute kidney injury patients based on RNA-seq
Conclusion: To our knowledge, this research is the first study to describe changes in the expression profiles of circRNAs, miRNAs, and mRNAs in patients with SAKI. These findings provide a new treatment target for SAKI treatment and novel ideas for its pathogenesis.
Source: Frontiers in Genetics - September 14, 2023 Category: Genetics & Stem Cells Source Type: research

miR-17 ~ 92 suppresses proliferation and invasion of cervical cancer cells by inhibiting cell cycle regulator Cdt2
In this study, we report that miR-17 ~ 92 directly recruits to 3’UTR of Cdt2 and downregulates this oncogene which suppresses the proliferation, migration and invasion capabilities of the CC cell lines without affecting non-cancerous cells. We further show that suppression o f Cdt2 by miR-17 ~ 92, blocks the cancerous cells in S phase and induces apoptosis, eventually leading to their death. Hence, our work for the first time, mechanistically shows how miR-17 ~ 92 could work as tumor suppressor in cervical cancer cells, opening up the potential of miR-17 ~ 9 2 to be used in developing therapy for cervical cancer treatment.
Source: Hormones and Cancer - September 14, 2023 Category: Cancer & Oncology Source Type: research

Peripheral Blood MicroRNAs as Biomarkers of Schizophrenia: Expectations from A Meta-Analysis That Combines Deep Learning Methods
CONCLUSIONS: A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.PMID:37703215 | DOI:10.1080/15622975.2023.2258975
Source: The World Journal of Biological Psychiatry - September 13, 2023 Category: Psychiatry Authors: Shiyuan Han Yongning Li Jun Gaoa Source Type: research

Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics
CONCLUSIONS: In conclusion, we find that hPSC-CMs are regulated in a cell autonomous manner during early development that diverges significantly as a function of time when compared to in vivo derived CMs. These findings demonstrate the feasibility of using CGRM to reveal dynamic and complex transcriptional and posttranscriptional regulatory interactions that underlie cell directed versus environment-dependent CM development. These results with in vitro versus in vivo derived CMs thus establish this approach for detailed analyses of heart disease and for the analysis of cell regulatory systems in other biomedical fields.PMI...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Shumin Li Bin Yan Binbin Wu Junhao Su Jianliang Lu Tak-Wah Lam Kenneth R Boheler Ellen Ngar-Yun Poon Ruibang Luo Source Type: research

Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer
CONCLUSION: Our study identified SCLC-specific exosomal miRNAs, and the 3-miRNAs panel (miR-200b-3p, miR-3124-5p and miR-92b-5p) may serve as a diagnostic and prognostic marker for SCLC.PMID:37705067 | DOI:10.1186/s40364-023-00517-1
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Dong Ha Kim Hyojeong Park Yun Jung Choi Kyungtaek Im Chae Won Lee Da-Som Kim Chan-Gi Pack Hyun-Yi Kim Chang-Min Choi Jae Cheol Lee Wonjun Ji Jin Kyung Rho Source Type: research

Bioinformatics identification and integrative analysis of ferroptosis-related key lncRNAs in patients with osteoarthritis
CONCLUSION: Comprehensive bioinformatics analysis of the FRGs-related ceRNA network determined three molecular biomarkers of lncRNAs that might be affiliated with OA progression.PMID:37702097 | DOI:10.1042/BSR20230255
Source: Bioscience Reports - September 13, 2023 Category: Biomedical Science Authors: Tengyun Yang Guang Yang Guoliang Wang Di Jia Bohan Xiong Xiaojun Lu Yanlin Li Source Type: research

MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research

miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine
CONCLUSION: We highlighted that miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under tetrandrine treatment.PMID:37702425 | DOI:10.14670/HH-18-657
Source: Histology and Histopathology - September 13, 2023 Category: Cytology Authors: Min Wang Kai Liu Zhongming Zhou Huizhuan Geng Source Type: research

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