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Total 58416 results found since Jan 2013.

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

MicroRNAs and their regulators: Potential therapeutic targets in pulmonary arterial hypertension
Vascul Pharmacol. 2023 Sep 10;153:107216. doi: 10.1016/j.vph.2023.107216. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by pulmonary arterial remodeling. Despite that current combination therapy has shown improvement in morbidity and mortality, a better deciphering of the underlying pathological mechanisms and novel therapeutic targets is urgently needed to combat PAH. MicroRNA, the critical element in post-transcription mechanisms, mediates cellular functions mainly by tuning downstream target gene expression. Meanwhile, upstream regulators can regul...
Source: Vascular Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yang-Zhi-Ge He Yi-Xuan Wang Jing-Si Ma Ruo-Nan Li Jia Wang Tian-Yu Lian Yu-Ping Zhou Hao-Pu Yang Kai Sun Zhi-Cheng Jing Source Type: research

GSE242923 miRNA expression profile from Adipocyte-derived Small Extracellular Vesicles from the Serum and cerebrospinal fluid of Alzheimer Disease Patients and Controls
Contributors : Rachael A Batabyal ; Ankush Bansal ; Laura Reck Cechinel ; Kayla Authelet ; Madeleine Goldberg ; Evan Nadler ; C D Keene ; Suman Jayadev ; Kimiko Domoto-Reilly ; Gail Li ; Elaine Peskind ; Kazue Hashimoto-Torii ; Dedra Buchwald ; Robert J FreishtatSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructMidlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have been implicated as a mecha-nism in several obesity-related diseases. We hypothesized that ad-sEVs from patients with AD would contain miRNAs predicted to downre...
Source: GEO: Gene Expression Omnibus - September 12, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research

GSE239453 Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing
We report here that in C. elegans, two conserved serine/threonine kinases - Casein Kinase 1 alpha 1 (CK1A1) and Casein Kinase 2 (CK2) - regulate a highly conserved phosphorylation cluster of 4 Serine residues (S988:S998) on the miRNA-specific AGO protein ALG-1. We show that CK1A1 phosphorylates ALG-1 at sites S992 and S995, while CK2 phosphorylates ALG-1 at sites S988 and S998. Furthermore, we demonstrate that phospho-mimicking mutants of the entire S988:S998 cluster rescue the various developmental defects observed upon depleting CK1A1 and CK2. In humans, we show that CK1A1 also acts as a priming kinase of this cluster on...
Source: GEO: Gene Expression Omnibus - September 12, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Caenorhabditis elegans Source Type: research

Expression of microRNA-379 reduces metastatic spread of prostate cancer
DiscussionTaken together, our in vitro and in vivo functional assays support a role for miR-379 as a tumour suppressor. A potential mechanism is unravelled whereby miR-379 deregulation in PCa cells affects the secretion of GDF-15 from osteoblasts which in turn facilitates the metastatic establishment in bone. Our findings support the potential role of miR-379 as a therapeutic solution for prostate cancer.
Source: Frontiers in Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research

Specific downregulation of microRNA-186 induces neural stem cell self-renewal by upregulating Bmi-1/FoxG1 expression
In this study, we isolated primary NSCs from the forebrain of fetal rat for in vitro analysis. Downregulation of miRNA-186 in response to a specific miRNA inhibitor resulted in upregulation of Bmi-1 and FoxG1, while maintaining NCS self-renewal. Bmi-1 overexpression restored the maintenance of NSCs in vitro. FoxG1 was found to promote the methylation of Foxo3 promoter and inhibited Foxo3 expression. miR-186 upregulation increased the expression of Foxo3 and inhibited NSC self-renewal in the absence of Foxo3. Therefore, we propose that downregulation of miR-186 maintained NSC self-renewal in the postnatal brain by upregulat...
Source: Human Cell - September 12, 2023 Category: Cytology Source Type: research

Roles of Immune and Oxidative Stress-Related Factors in the Diagnosis of Coronary Artery Disease: A Retrospective Study
CONCLUSIONS: Bioinformatics analysis technology was used to identify 10 hub DEIOGs that might play a crucial role in CAD progression, and five special hub genes (Fos, Il6, Jun, Mapk3, and Mmp9) could be regarded as potential biomarkers for CAD diagnosis. However, further studies are required to verify the functions of these hub genes.PMID:37691276 | DOI:10.59958/hsf.5799
Source: The Heart Surgery Forum - September 11, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Yue Shu Yin Zheng Yilong Guo Dan Zhu Shian Huang Source Type: research

CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research

Molecular complexity of mammary glands development: a review of lactogenic differentiation in epithelial cells
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):491-508. doi: 10.1080/21691401.2023.2252872.ABSTRACTThe mammary gland is a dynamic organ with various physiological processes like cellular proliferation, differentiation, and apoptosis during the pregnancy-lactation-involution cycle. It is essential to understand the molecular changes during the lactogenic differentiation of mammary epithelial cells (MECs, the milk-synthesizing cells). The MECs are organized as luminal milk-secreting cells and basal myoepithelial cells (responsible for milk ejection by contraction) that form the alveoli. The branching morphogenesis and lactog...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 11, 2023 Category: Biotechnology Authors: Manoj Kumar Jena Farheen Badrealam Khan Syed Azmal Ali Abdullah Abdullah Amarish Kumar Sharma Vikas Yadav Sudhakar Kancharla Prachetha Kolli Gowtham Mandadapu Anjan Kumar Sahoo Prasana Kumar Rath Jalal Taneera Sudarshan Kumar Ashok Kumar Mohanty Khang Wen Source Type: research

Colorectal cancer cell-secreted exosomal miRNA N-72 promotes tumor angiogenesis by targeting CLDN18
Am J Cancer Res. 2023 Aug 15;13(8):3482-3499. eCollection 2023.ABSTRACTAngiogenesis is essential for the growth and metastasis of several malignant tumors including colorectal cancer (CRC). The molecular mechanism underlying CRC angiogenesis has not been fully elucidated. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the intercellular communication between tumor cells and neighboring endothelial cells to regulate tumor angiogenesis. In addition, exosomes have been shown to carry and deliver miRNAs to regulate angiogenesis. miRNA N-72 is a novel miRNA that plays a regulatory role in the EGF-induce...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ying Li Di Jiang Zhi-Xin Zhang Jun-Jun Zhang Hong-Yu He Jian-Li Liu Ting Wang Xia-Xia Yang Bang-Dong Liu Li-Li Yang Xiao Zhi Xiao-Bei Zhang Tian-Lun Li Yan-Rong Liu Source Type: research

CircCRIM1 suppresses osteosarcoma progression via sponging miR146a-5p and targeting NUMB
Am J Cancer Res. 2023 Aug 15;13(8):3463-3481. eCollection 2023.ABSTRACTCircCRIM1 (hsa_circ_0002346) is a circular RNA derived from gene CRIM1 (the cysteine rich transmembrane BMP regulator 1 circRNAs) by back-splicing. Recent studies have suggested the diverse function of CircCRIM1 in the tumorigenesis of multiple malignancies, including osteosarcoma (OS). Here, we investigated the role and mechanism of circCRIM1 during OS progression. Differentially expressed circRNAs (including circCRIM1) in OS and human osteoblast (hFOB1.19) cell lines were selected by searching the circRNA expression microarray dataset of GSE96964. The...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jinnan Chen Ruoxuan Hei Chen Chen Xuan Wu Tiaotiao Han Huiqin Bian Junxia Gu Yaojuan Lu Qiping Zheng Source Type: research

Bioinformatics, RNA sequencing, and targeted bisulfite sequencing analyses identify the role of PROM2 as a diagnostic and prognostic biomarker
CONCLUSION: Via this study, we effectively revealed PROM2 overexpression as a potential diagnostic and prognostic biomarker of survival in BRCA, LUAD, and UCEC.PMID:37692961 | PMC:PMC10492044
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Arsalan Ahmed Uqaili Gulzar Usman Urooj Bhatti Hilal Nasir Rabeea Zia Muhammad Aitzaz Akram Fahim Ali Jawad Afshan Farid Mohamed Ragab AbdelGawwad Saeedah Musaed Almutairi Mohamed S Elshikh Sajid Hussain Rabab Ahmed Rasheed Source Type: research

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